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Abstracts tagged "epigenomics"

  • Abstract Number: 1789 • ACR Convergence 2021

    Prediction of Psoriatic Arthritis in Patients with Psoriasis Using DNA Methylation Profiles

    Omar Cruz Correa1, Remy Pollock1, Rohan Machhar2 and Dafna Gladman3, 1University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) poses an immense clinical burden with significantly increased morbidity and mortality risk compared to psoriasis alone. PsA may develop in 30%…
  • Abstract Number: 783 • ACR/ARP Annual Meeting 2019

    Differences in Chromatin Architecture in Treatment Naïve Pediatric Lupus Patients

    Joyce Hui-Yuen1, Frank Jenkins 2, Kaiyu Jiang 3, Susan Malkiel 2, Betty Diamond 4 and James N. Jarvis 5, 1Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY, 2Feinstein Institute for Medical Research, Manhasset, 3University at Buffalo Jacobs School of Medicine, Buffalo, NY, 4Feinstein Institutes for Medical Research, Manhasset, 5University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex disease likely triggered by gene-environment interactions. We have shown that most of the SLE-associated haplotypes encompass genomic…

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