Abstracts tagged "Epigenetics and transcriptional regulation"

Abstract Number: 1863 • 2015 ACR/ARHP Annual Meeting
Epigenetic Changes in SLE Implicate Enhancers As a Force in Pathologic Cell Behavior
Lihua Shi¹, Li Song¹, Zhe Zhang², Michelle Petri³ and Kathleen E. Sullivan⁴, ¹Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Bioinformatics, Children's Hospital of Philadelphia, Bioinformatics, Philadelphia, PA, ³Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ⁴Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: We previously identified novel non-coding RNAs that were markedly overexpressed in SLE patient monocytes. Among all classes of RNAs, these non-coding RNAs were by…
Abstract Number: 1864 • 2015 ACR/ARHP Annual Meeting
H3K4me3 Peak Shape Dictates Transcription and Regulates Differential Expression in SLE
Kathleen E. Sullivan¹, Lihua Shi², Li Song³, Michelle Petri⁴ and Zhe Zhang⁵, ¹Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ⁵Bioinformatics, Children's Hospital of Philadelphia, Bioinformatics, Philadelphia, PA
Background/Purpose: H3K4me3 is a post-translational modification of histone H3 associated typically with gene activation. We had previously characterized changes in H3K4me3 associated with SLE in…

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