Abstracts tagged "Epigenetics and systemic sclerosis"

Abstract Number: 754 • 2014 ACR/ARHP Annual Meeting
The Global miRNA Whole Blood Profile in Systemic Sclerosis and Its Correlation with Serum Cytokine Levels
Gloria Salazar¹, Maureen Mayes², John Hagan³, Minghua Wu¹, John D. Reveille^4,5 and Shervin Assassi¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Internal Medicine/Rheumatology, University of TX Health Science Center -Houston, Houston, TX, ³Neurosurgery, University of Texas at Houston, Houston, TX, ⁴Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁵Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
The Global miRNA Whole Blood Profile in Systemic Sclerosis and its Correlation with Serum Cytokine LevelsBackground/Purpose: Several studies have implicated miRNAs in the pathogenesis of…
Abstract Number: 1902 • 2013 ACR/ARHP Annual Meeting
Characterization Of HLA-DRB1 Distribution By 3rd Hypervariable Region Sequence In Systemic Sclerosis and Control Populations
Coline, A. Gentil¹, Hilary S. Gammill¹, Christine, T. Luu¹ and J. Lee Nelson², ¹Immunogenetics, Fred Hutchinson Cancer Research Center, SEATTLE, WA, ²Immunogenetics D2-100, Fred Hutchinson Cancer Rsch, Seattle, WA
Background/Purpose: HLA class II genes are associated with a wide spectrum of autoimmune diseases. Specific alleles at the DRB1, DQA1 and DQB1 loci are associated…
Abstract Number: 655 • 2013 ACR/ARHP Annual Meeting
DNA Methylation and Systemic Sclerosis
Gloria Salazar¹, Khurshida Begum², Xinjian Guo³, Minghua Wu¹, Shervin Assassi¹, Maureen D. Mayes¹, John D. Reveille¹ and Xiaodong Zhou¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Baylor College of Medicine, Houston, TX, ³Rheumatology, The University of Texas Medical School at Houston, Houston, TX
DNA Methylation and Systemic SclerosisBackground/Purpose: Epigenetic modiﬁcations are stable and heritable alterations in gene expression and cellular function that do not involve changes to the…
Abstract Number: 783 • 2012 ACR/ARHP Annual Meeting
The Wnt Inhibitors DKK1 and SFRP1 Are Downregulated by Promoter Hypermethylation in Systemic Sclerosis
Clara Dees¹, Inga Schlottmann¹, Robin Funke¹, Alfiya Distler², Katrin Palumbo-Zerr², Pawel Zerr², Oliver Distler³, Georg A. Schett⁴ and Joerg HW Distler², ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Tissue fibrosis caused by pathological activation of fibroblasts is a major hallmark of systemic sclerosis (SSc). Epigenetic gene silencing of anti-fibrotic genes such as…