Abstracts tagged "epigenetics and systemic lupus erythematosus (SLE)"

Abstract Number: 2884 • 2016 ACR/ARHP Annual Meeting
Cell-Type Specific Epigenetic Features of Systemic Lupus Erythematosus
Neelakshi R. Jog¹, Richard C. Pelikan¹, Melissa Bebak², Joel M. Guthridge³, Judith A. James¹ and Patrick M. Gaffney¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma city, OK, ³Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that involves multiple organ systems and periods of variable disease activity. Although SLE, especially in…
Abstract Number: 1623 • 2013 ACR/ARHP Annual Meeting
Differential Methylation Of Interferon-Related Genes Is Associated With Anti-dsDNA Autoantibody Production In Systemic Lupus Erythematosus
Sharon A. Chung¹, Joanne Nititham², Kimberly E. Taylor¹, Emon Elboudwarej³, Hong L. Quach³, Lisa F. Barcellos³ and Lindsey A. Criswell², ¹University of California, San Francisco, San Francisco, CA, ²Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ³Epidemiology, University of California, Berkeley, Berkeley, CA
Background/Purpose: DNA methylation studies in systemic lupus erythematosus (SLE) have shown that SLE patients have less methylation in genes regulating the immune response compared to…
Abstract Number: 2268 • 2012 ACR/ARHP Annual Meeting
Hyperacetylation of Histone H4 in Systemic Lupus Erythematosus
Yiu Tak Leung¹, Lihua Shi², Kelly Maurer², Li Song², Zhe Zhang³, Michelle Petri⁴ and Kathleen E. Sullivan², ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Bioinformatics, Bioinformatics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is the prototypical autoimmune disease and is characterized by multi-systemic chronic inflammation. Epigenetic processes, such as posttranslational histone modifications, can…

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