Abstracts tagged "Epigenetics and scleroderma"

Abstract Number: 3016 • 2015 ACR/ARHP Annual Meeting
Bromodomain Inhibitor JQ1 Modulates Smooth Muscle Cell Switching and Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension in Mice
Sarah L. Trinder¹, Adrian Gilbane², Robert Good², Emma C. Derrett-Smith³, Christopher P. Denton⁴, David Abraham⁵ and Alan M. Holmes², ¹Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases,, UCL Division of Medicine, London, United Kingdom, ⁴Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁵Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom
Background/Purpose: Pulmonary arterial hypertension (PAH) represents a serious co-morbidity affecting up to 10% of systemic sclerosis (SSc) patients. Cardinal features of PAH include inflammation and…

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