Abstracts tagged "epigenetics and rheumatoid arthritis (RA)"

Abstract Number: 920 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patient-Specific Therapeutic Target Identification Using Integrative Epigenetic Profiling
Richard Ainsworth¹, Kai Zhang², Lina Zheng³, Gary S. Firestein⁴ and Wei Wang⁵, ¹UC San Diego, La Jolla, CA, ²UCSD School of Engineering, San Diego, CA, ³Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁴Medicine, UC San Diego, La Jolla, CA, ⁵Chemistry and Biochemistry, University of California San Diego, La Jolla, CA
Background/Purpose: To explain the complex regulatory changes associated with RA synovitis and the diversity of responses to targeted therapies, we developed and applied a novel…
Abstract Number: 74 • 2016 ACR/ARHP Annual Meeting
Arthritis-Associated DNA Hypermethylation Provokes Increased Antibody Expression in Mouse Model of Rheumatoid Arthritis
Daniel M. Tóth¹, Timea Ocskó¹, Adrienn Markovics¹, Attila Balog², Katalin Mikecz¹, Tibor T. Glant¹ and Tibor A. Rauch¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary
Background/Purpose: Although a number of epigenetic alterations have been revealed in rheumatoid arthritis (RA), it remained an open question whether these epimutations play role in…
Abstract Number: 20 • 2015 ACR/ARHP Annual Meeting
Role of the Epigenetic Regulator EZH2 in Proinflammatory Macrophage Polarization and Signaling in Rheumatoid Arthritis
Michelle Trenkmann¹, Eimear Linehan², Mary Canavan³, Douglas J. Veale⁴ and Ursula Fearon¹, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ²St. Vincent's University Hospital Dublin, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, ³St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, ⁴St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland
Background/Purpose: In rheumatoid arthritis (RA), synovial tissue macrophages (MΦ) are inherently involved in disease pathogenesis by producing inflammatory mediators and matrix-destructive enzymes. Depending on their…
Abstract Number: 110 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Epigenetic Profiling of Monozygotic Twins[L1] Discordant for ACPA or ACPA-Positive Rheumatoid Arthritis Reveals Novel Associated Genes
David Gomez¹, Malin Almgren², Louise Sjoholm², Aase Haj Hensvold³, Andrew Feinberg⁴, L. Klareskog⁵, Tomas Ekstrom^2,6 and Anca I Catrina⁵, ¹Unit of Computational Medicine Karolinska Institutet Center for Molecular Medicine Karolinska University Hospital, stockholm, Sweden, ²Laboratory for Medical Epigenetics, Dept. of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ⁴Department of Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Departmen of Clinical Neuroscience, karolinska Institute, Stockholm, Sweden
Background/Purpose: Occurrence and progression of complex autoimmune diseases are orchestrated by interactions between genes and environment, in part mediated by epigenetic mechanisms. It is yet…
Abstract Number: 1623 • 2015 ACR/ARHP Annual Meeting
Genome-Wide Association Study of DNA Methylation in Th1 and Th17 Cells in Rheumatoid Arthritis
Katharina Stutzer¹, Fausto Pirronello¹, Simone Wahl², Hendrik Schulze-Koops¹, Alla Skapenko¹ and Jan Leipe³, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Munich, Germany, ³Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Munich, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by systemic inflammation. Although the understanding of the pathogenesis is incomplete, there is substantial evidence…
Abstract Number: 1884 • 2014 ACR/ARHP Annual Meeting
Differential DNA Methylation Associated with Rheumatoid Arthritis in Disease Discordant Monozygotic Twins
Amy Webster¹, Flore Zufferey², Darren Plant³, Anne Barton^4,5, Frances Williams² and Jane Worthington^1,6, ¹Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, ²Dept Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, ⁵NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁶The University of Manchester, Manchester, United Kingdom
Background/Purpose: Previous epigenetic studies of rheumatoid arthritis (RA) using prevalent cases and unrelated controls have indicated that DNA methylation is altered in patients with RA.…

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