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Abstracts tagged "epigenetics and rheumatic disease"

  • Abstract Number: 73 • ACR/ARHP Annual Meeting 2016

    Dysregulation of Hypomethylated Age-Related CpG Sites Characterize T-Cells and Monocytes from Treatment Naive Rheumatoid Arthritis Subjects

    Ines Colmegna1, Marie Forest2, Aurelie Labbe3, Sasha Bernatsky4, Jose Navarro5, Tomi Pastinen6, Celia Greenwood7 and Marie Hudson8, 1Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, 3Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, Canada, 4Division of Rheumatology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 5Experimental Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 6Human Genetics, McGill University, Montreal, QC, Canada, 7Centre for Clinical Epidemiology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, 8Medicine/Rheumatology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada

    Background/Purpose: In the general population, an increase in chronological age is associated with differential DNA methylation of particular CpGs in a highly conserved fashion. Since…

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