Abstracts tagged "epigenetics and pathogenesis"

Abstract Number: 1947 • ACR/ARHP Annual Meeting 2015
Hypermethylation of Treg-Specific Demethylated Regions in the Ikaros Transcription Factor Family Members, Helios and Eos, in Rheumatoid Arthritis Tregs
Alla Skapenko¹, Viktoria Soentgerath¹, Sonja Haupt², Jan Leipe¹ and Hendrik Schulze-Koops¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany
Background/Purpose: Foxp3 is the signature transcription factor of regulatory T cells (Tregs) and facilitates many of the characteristic functions of Tregs. Members of the Ikaros…
Abstract Number: 2845 • ACR/ARHP Annual Meeting 2014
Altered Plasticity of Inflammatory CD4 T Cells Contributing to Th17 Shift in Rheumatoid Arthritis
Jan Leipe, Fausto Pirronello, Simon Hermann, Matthias Witt, Hendrik Schulze-Koops and Alla Skapenko, Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose Whereas T helper (Th) cell subsets were previously regarded as irreversibly differentiated endpoints, evidence suggests that Th cell differentiation is a plastic process in…