Abstracts tagged "epigenetics and osteoarthritis"

Abstract Number: 1219 • 2016 ACR/ARHP Annual Meeting
Differential Peripheral Blood DNA Methylation Patterns Are Predictive of Radiographic OA Progression
Matlock A. Jeffries¹, Madison Andrews², Judith A. James³, Mary Beth Humphrey⁴ and Amr H. Sawalha⁵, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Medicine/Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Extensive evidence has correlated epigenetic alterations in articular tissues with both the presence and progression of human osteoarthritis, but data regarding extraarticular tissues are…
Abstract Number: 1002 • 2014 ACR/ARHP Annual Meeting
Global Transcriptome Analysis in Osteoarthritic Cartilage Reveals Significant Differential Gene Expression and Associations with Histologic Disease Progression
Matlock A. Jeffries^1,2, Madison Donica³, Anand Annan⁴, Michael Stevenson⁵, Mary Beth Humphrey^6,7, Judith A. James^6,8 and Amr H. Sawalha⁹, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Pathol;ogy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Rheumatology/Immunology/Arthritis Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic disability affecting 40% of individuals over the age of 70 and costing $128 billion annually in…
Abstract Number: 1893 • 2013 ACR/ARHP Annual Meeting
Altered DNA Methylation Profiles In Individuals With Osteoarthritis
Kathryn A Bailey¹, Daniel Rojas², Nikhil Umesh¹, Lisa Smeester¹, Tristan De Buysscher³, Jordan B. Renner⁴, Joanne M. Jordan⁵ and Rebecca C. Fry¹, ¹Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²School of Medicine, Curriculum in Toxicology, Univeristy of North Carolina at Chapel Hill, Chapel Hill, NC, ³Center for Bioinformatics, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴University of North Carolina Department of Radiology, Chapel Hill, NC, ⁵Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Major risk factors associated with osteoarthritis (OA) development include age, joint stress/injury, obesity, and genetic predisposition. In recent years, the role epigenetic processes that…
Abstract Number: 1898 • 2013 ACR/ARHP Annual Meeting
Repression Of Wolf-Hischhorn Syndrome Candidate-1 (WHSC1) Contributes To The Osteoarthritis-Inducing Cartilage Loss Of Functions
Francisco Espinoza¹, Yves-Marie Pers², Paul Chuchana³, Jean Marc Brondello⁴ and Christian Jorgensen², ¹INSERM U844, MONTPELLIER, France, ²Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, ³INSERM U844, Montpellier, France, ⁴Inserm U844, UM1, Montpellier, France
Background/Purpose: Accumulation of senescent p16INK4A-positive cells within numerous tissues through out life span contributes to the onset of several age-related disease such as intervertebral disc…
Abstract Number: 61 • 2013 ACR/ARHP Annual Meeting
Epigenome-Wide DNA Methylation Study Reveals Hypermethylated Collagen Genes and Suggests a Role for TGFβ in Osteoarthritis
Matlock A. Jeffries^1,2, Amr H. Sawalha³ and Judith A. James⁴, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic disability in the U.S., affecting 40% of individuals over the age of 70 and costing $128…

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