Abstracts tagged "epigenetics and lupus nephritis"

Abstract Number: 1245 • 2015 ACR/ARHP Annual Meeting
Differential DNA Methylation Associated with Lupus Nephritis Shows Enrichment in Genes Involved in Regulation of TH2 Differentiation and Renal Development
Renuka Nayak¹, Sharon A. Chung², Joanne Nitiham³ and Lindsey A. Criswell³, ¹Department of Medicine, UCSF, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ²Russell/Englemen Rheumatology Research Center, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ³Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Genetic and epigenetic factors contribute to the progression of systemic lupus erythematosus (SLE). We have the ability to identify these factors and their influence…
Abstract Number: 2501 • 2012 ACR/ARHP Annual Meeting
Mirorna Mir-150 Contributes to Chronic Kidney Injury in Lupus Nephritis by Increasing the Synthesis of Fibrotic Proteins Via Downregulation of SOCS1
Hua Zhou¹, Sarfaraz A. Hasni², Mayank Tandon³, Shyh-Ing Jang⁴, Howard A. Austin⁵, James E. Balow⁶, Ilias Alevizos³ and Gabor G. Illei³, ¹NIDCR/NIH, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Sjogren's Clinic, NIDCR/NIH, Bethesda, MD, ⁴Molecular Physiology and Therapeutics Branch, NIDCR/NIH, Bethesda, MD, ⁵Kidney Disease Section, NIDDK/NIH, Bethesda, MD, ⁶Clinical Director, NIDDK, NIDDK/NIH, Bethesda, MD
Background/Purpose: We have previously shown that renal expression of miR-150 correlates with chronicity index (CI) in lupus nephritis. Since fibrosis is a major histologic feature…

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