epigenetics and innate immunity Archives

Abstract Number: 1373 • ACR/ARHP Annual Meeting 2015
Epigenetic Mechanisms Contribute to the Lack of LPS-Induced Tolerance in Rheumatoid Arthritis Synovial Fibroblasts
Kerstin Klein¹, Renate E. Gay¹, Christoph Kolling², Adrian Ciurea¹, Diego Kyburz¹, Beat A. Michel¹, Lih-Ling Lin³, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ³Inflammation and Immunology Research Unit, Pfizer, Cambridge, MA
Background/Purpose: In macrophages, repeated stimulation of Toll-like receptor (TLR) 4 leads to a tolerant state of the cell which protects inflamed tissues from damage. We…

Abstracts tagged "epigenetics and innate immunity"