Abstracts tagged "epigenetics and CD T cells"

Abstract Number: 91 • 2019 ACR/ARP Annual Meeting
Histonedeacetylase 1 (HDAC1): A Key Mediator of T Cells for the Pathogenesis of Rheumatoid Arthritis
Lisa Goschl ¹, Victoria Saferding ¹, Nicole Boucheron ², Johan Backlund ³, Alexander Platzer ¹, Kiyoshi Hirahara ⁴, Han-yu Shih ⁵, Patrick Matthias ⁶, Clemens Scheinecker ¹, Günter Steiner ⁷, Wilfried Ellmeier ² and Michael Bonelli¹, ¹Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ²Institute of Immunology, Division of Immunobiology, Medical University of Vienna, Vienna, Austria, ³Medical Inflammation Research, Karolinska Institute; Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, ⁴Graduate School of Medicine, Chiba University, Chiba, Japan, ⁵National Institute of Arthritis, National Institutes of Health, Bethesda, ⁶Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, ⁷Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria, Vienna, Austria
Background/Purpose: Despite enormous efforts to develop new therapeutic strategies for treatment of rheumatoid arthritis (RA), the large number of non responding patients to currently available…

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