Abstracts tagged "Epidemiologic methods"

Abstract Number: 2759 • 2013 ACR/ARHP Annual Meeting
Can RA Registries Provide Contextual Safety Data For Modern RCTs?
Kaleb Michaud¹, Johan Askling², Hisashi Yamanaka³, Deborah Symmons⁴, Marie Holmqvist², Thomas Frisell⁵, George Reed⁶, Dimitrios A. Pappas⁷, Eiichi Tanaka⁸, Eisuke Inoue⁹, Suzanne M.M. Verstappen⁴, Christopher Garwood⁴, Laura Horne¹⁰, Kathy Lampl¹¹, Niklas Berglind¹², Stefan Franzen¹², Fredrik Nyberg¹³, Trung Tran¹⁴, Meilien Ho¹⁵ and Jeffrey D. Greenberg¹⁶, ¹Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE, ²Karolinska Institutet, Stockholm, Sweden, ³Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁴Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ⁵Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Orthopedics, University of Massachusetts Medical School, Worcester, MA, ⁷Columbia University, New York, NY, ⁸Tokyo Women's Medical University, Tokyo, Japan, ⁹Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, ¹⁰AstraZeneca, Wilmington, DE, ¹¹AstraZeneca R&D Wilmington, Wilmington, DE, ¹²AstraZeneca R&D Mölndal, Mölndal, Sweden, ¹³AstraZeneca R&D, Mölndal, Sweden, ¹⁴MedImmune LLC, Gaithersburg, MD, ¹⁵AstraZeneca R&D Alderley Park, Macclesfield, United Kingdom, ¹⁶New York University School of Medicine, New York, NY
Background/Purpose: For ethical reasons, modern phase-III RCTs in rheumatoid arthritis (RA) have limited placebo exposure time, resulting in uncertainties when interpreting low frequency adverse events…
Abstract Number: 1052 • 2013 ACR/ARHP Annual Meeting
Glucocorticosteroids and Mortality Risk In Rheumatoid Arthritis – Results Of a Population Based Study
Diane Lacaille¹, J. Antonio Avina-Zubieta^2,3, Eric C. Sayre², Michal Abrahamowicz⁴ and John Esdaile^1,5, ¹Rheumatology, Arthritis Research Centre of Canada, University of British Columbia, Richmond, BC, Canada, ²Arthritis Research Centre of Canada, Richmond, BC, Canada, ³Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Division of Clinical Epidemiology, McGill University, Montreal, QC, Canada, ⁵Medicine, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Glucocorticosteroids (GC) are frequently used in the management of rheumatoid arthritis (RA). Due to their metabolic and immunosuppressive effects, they could increase the risk…
Abstract Number: 2682 • 2013 ACR/ARHP Annual Meeting
Incidence Trends and Predictors Of Orthopedic Surgery In Patients With Rheumatoid Arthritis – Results From a Well Defined Population
Korosh Hekmat¹, Lennart Jacobsson², Jan-Åke Nilsson³, Minna Willim⁴, Martin Englund⁵, Ingemar F. Petersson⁶ and Carl Turesson², ¹Department of Clinical Sciences, Section of Rheumatology, Malmö, Lund University, Malmö, Sweden, ²Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Department of Clinical Sciences Malmö, Section of Rheumatology, Lund University, Malmö, Sweden, ⁵Department of Orthopedics, Clinical Sciences Lund,, Lund University, Lund, Sweden, ⁶Musculoskeletal Scienes, Department of Orthopedics, Clinical Sciences, Lund, Sweden
Background/Purpose: Orthopedic surgery is used effectively in many patients with severe rheumatoid arthritis (RA). The aim of modern pharmacologic treatment is to prevent joint destruction…
Abstract Number: 1067 • 2013 ACR/ARHP Annual Meeting
Incidence and Prevalence Of Systemic Lupus Erythematosus: A 2010 Nation-Wide Population-Based Study Using French National Administrative Databases
Laurent Arnaud¹, Jean-Paul Fagot², Michel Païta², Alexis Mathian³, Anne Fagot-Campagna² and Zahir Amoura⁴, ¹Internal Medicine, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, ²Caisse Nationale d’Assurance Maladie des Travailleurs Salariés, Paris, France, ³Internal Medicine Dpt 2, Pitié-Salpêtrière Hospital, APHP, Paris, France, ⁴Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France
Background/Purpose: To date, only a small number of studies have examined the epidemiology of systemic lupus erythematosus (SLE) on a nation-wide basis. These studies were…
Abstract Number: 2661 • 2013 ACR/ARHP Annual Meeting
Physical Activity, Adiposity, and The Risk Of Gout In Women: The Nurses Health Study
Hyon Choi^1,2,3, Lindsay C Burns^4,5, Yuqing Zhang⁶, Sharan Rai¹ and Gary Curhan⁷, ¹Arthritis Research Centre of Canada, Richmond, BC, Canada, ²Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Research, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁵Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada, ⁶Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁷German Research Center for Environmental Health, Harvard Medical School, Boston, MA
Background/Purpose: There is a remarkable, increasing disease burden of gout and its associated cardiovascular (CV)-metabolic comorbidities in the US. While the benefits of physical exercise…
Abstract Number: 1071 • 2013 ACR/ARHP Annual Meeting
Prevalence Of Systemic Lupus Erythematosus and Lupus Nephritis In The United States: Analysis Of Commercial and Public Insurance Billing Data
Kunal Gandhi¹, Evo Alemao¹, Hugh Kawabata¹ and Jan L. Hillson², ¹Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Seattle, WA
Background/Purpose: Prevalence estimates of Systemic Lupus Erythematosus (SLE) in the U.S. vary, with numbers ranging from 161,000 (Helmick, 2008) to 1.5 million (Lupus Foundation of…
Abstract Number: 1001 • 2012 ACR/ARHP Annual Meeting
CNstream2: Improved SNP and CNV Genotyping Reveals New Loci Associated with Rheumatic Diseases
Arnald Alonso, Antonio Julià, Raül Tortosa and Sara Marsal, Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain
Background/Purpose: In Genome-Wide Association Studies (GWAS), the performance of the genotyping algorithm is crucial to identify new SNPs associated to disease risk. Recently, new methods…
Abstract Number: 951 • 2012 ACR/ARHP Annual Meeting
A Systematic Review of Quality of Prognosis Studies in Systemic Lupus Erythematosus
Lily Siok Hoon Lim¹, Senq-J Lee², Brian M. Feldman³, D. D. Gladman⁴, Eleanor Pullenayegum⁵ and Earl D. Silverman⁶, ¹Pediatric Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, ²Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁵Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada, ⁶Rheumatology, Pediatric Rheumatology Collaborative Study Group (PRSCG), Toronto, ON, Canada
Background/Purpose: Prognosis studies study future outcomes and/or seek to identify predictive or associative factors associated with outcomes. Strong and consistent prognostic factors can be used…
Abstract Number: 915 • 2012 ACR/ARHP Annual Meeting
Incidence of Knee, Hip, and Hand Clinical Osteoarthritis: A Population-Based Cohort Study
Daniel Prieto-Alhambra¹, Aina Pagès-Castellà², M. Kassim Javaid³, Andrew Judge⁴, Cyrus Cooper⁵, Nigel K. Arden⁶ and Adolfo Díez-Pérez⁷, ¹Internal Medicine; Primary Care; NDORMS Dept; MRC Lifecourse Epidemiology Unit, URFOA-IMIM, Parc de Salut Mar; Idiap Jordi Gol; University of Oxford; University of Southampton, Barcelona, Spain, ²Primary Care, IDIAP Jordi Gol; Institut Català de la Salut, Barcelona, Spain, ³Rheumatology, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK, Oxford, United Kingdom, ⁴Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁵NDORMS; MRC Lifecourse Epidemiology Unit, University of Oxford; Southampton General Hospital, Southampton, United Kingdom, ⁶NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁷Internal Medicine, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona; and RETICEF, ISCIII Madrid; Spain, Barcelona, Spain
TITLE: "Incidence of knee, hip, and hand clinical osteoarthritis: a population-based cohort study."AUTHORS: Daniel Prieto-Alhambra*, Aina Pag�s-Castellˆ, M Kassim Javaid, Andrew Judge, Cyrus Cooper, Nigel…
Abstract Number: 911 • 2012 ACR/ARHP Annual Meeting
Race- and Sex-Specific Estimates of 10-, 20-, 30-Year, and Lifetime Risk of Diagnosed Symptomatic Knee Osteoarthritis and the Need for TKR in the US
Elena Losina¹, Meghan E. Daigle¹, Sara A. Burbine¹ and Jeffrey N. Katz², ¹Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: A growing body of evidence suggests that females are more likely to be diagnosed with knee osteoarthritis (OA) and that obesity increases the risk…
Abstract Number: 728 • 2012 ACR/ARHP Annual Meeting
Does the Use of Angiotensin Converting Enzyme Inhibitors Prior to Scleroderma Renal Crisis Affect Prognosis ? – Results of the International Scleroderma Renal Crisis Survey
Marie Hudson¹, Murray Baron², Solene Tatibouet¹, Daniel Furst³, Dinesh Khanna⁴ and International Scleroderma Renal Crisis Study Investigaots⁵, ¹Jewish General Hospital, McGill University, Montreal, QC, Canada, ²Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³David Geffen School of Medicine, Div of Rheumatology, University of California at Los Angeles, Los Angeles, CA, ⁴Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Montreal
Background/Purpose: Scleroderma renal crisis (SRC) is an infrequent but life-threatening complication of systemic sclerosis (SSc). The outcome of SRC has improved considerably since the advent…
Abstract Number: 303 • 2012 ACR/ARHP Annual Meeting
Ancestral Group Differences in Pediatric SLE Early Disease Severity: An Analysis of the Carranet Registry
Jennifer M.P. Woo¹, Alice DC Hoftman¹, Emily von Scheven², Deborah K. McCurdy³, Ornella J. Rullo¹ and CARRA Registry Investigators⁴, ¹Pediatric Rheumatology, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA, ²Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA, ³Pediatric Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA, ⁴Durham, NC
Background/Purpose: Ancestral background may contribute to increased disease morbidity in patients with pediatric lupus systemic erythematosus (pSLE) of non-European descent; however, there exists a paucity…
Abstract Number: 174 • 2012 ACR/ARHP Annual Meeting
Prevalence, Risk Factors, and Functional Impact of Arthralgias Among Patients with Chronic Hepatitis C Virus Infection
Samir Bhangle¹, Vincent Lo Re², W. Gina Pang¹, Kyong-Mi Chang³, Valerianna Amorosa⁴, Jay Kostman⁵, H. Ralph Schumacher⁶ and Alexis Ogdie⁷, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Dept of Medicine/Infection Diseases, Dept of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ³Division of Gastroenterology, Philadelphia VA Medical Center, Philadelphia, PA, ⁴Division of Infectious Diseases, Philadelphia VA Medical Center, Philadelphia, PA, ⁵Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, ⁶Department of Medicine, University of Pennsylvania and VA Medical Center, Philadelphia, PA, ⁷Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The prevalence, risk factors and functional impact of joint pain are not well described in chronic hepatitis C virus (HCV)-infected patients, particularly in the…
Abstract Number: 2559 • 2012 ACR/ARHP Annual Meeting
Mortality in Patients with Psoriatic Arthritis Compared to Patients with Rheumatoid Arthritis, Psoriasis Alone, and the General Population
Alexis Ogdie¹, Kevin Haynes², Andrea Troxel², Thorvardur Love³, Hyon K. Choi⁴ and Joel Gelfand⁵, ¹Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA, ²Clinical Epidemiology and Biostatistics, University of Pennsylvania., Philadelphia, PA, ³Landspitali University Hospital, Reykjavik, Iceland, ⁴Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁵University of Pennsylvania., Philadelphia, PA
Background/Purpose: Conflicting reports of the mortality risk among patients with psoriatic arthritis (PsA) exist in the literature, however excess mortality has been presumed given the…
Abstract Number: 90 • 2012 ACR/ARHP Annual Meeting
Physical Function, Pain and Fatigue Are Related to Sleep Disturbance in Females with Rheumatoid Arthritis
Cathrine Austad¹, Tore K. Kvien² and Till Uhlig², ¹Department of Rheumatology, Diakonhjemmet Hospital, Norway, Oslo, Norway, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Sleep quality is an important aspect of health and well-being and the Outcome Measures in Rheumatology Clinical Trials group has identified sleep quality as…

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