Abstracts tagged "Enthesitis and spondylarthritis"

Abstract Number: 588 • ACR/ARP Annual Meeting 2019
The Gut Enthesis Axis Coming into Focus with the Description of Enriched Entheseal Resident Mucosal Associated Invariant T-cells (MAITs) Capable of IL17A and TNF Production
Richard Cuthbert ¹, Qiao Zhou ², Abdulla Watad ³, Robert Dunsmuir ⁴, Peter Loughenbury ⁴, Almas Khan ⁴, Peter Milner ⁴, Charles Bridgewood ⁵ and Dennis McGonagle², ¹University of Leeds, Leeds, ²University of Leeds, Leeds, United Kingdom, ³Department of Medicine “B”, Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Ramat-Gan, Israel, ⁴Leeds Teaching Hospitals NHS Trust, Leeds, ⁵Leeds Institute of Rheumatic and Muscoskeletal Medicine(LIRMM), University of Leeds, Leeds, United Kingdom
Background/Purpose: Mucosal associated invariant T-cells (MAITs) are innate-like T lymphocytes that express a semi-invariant TCR repertoire that are activated by microbial ligands or cytokines including…
Abstract Number: 2693 • ACR/ARHP Annual Meeting 2013
Proof Of Concept: Enthesitis and New Bone Formation In Spondyloarthritis Are Driven By Mechanical Strain and Stromal Cells
Peggy Jacques¹, Stijn Lambrecht¹, Eveline Verheugen¹, Elin Pauwels², Marleen Verhoye³, Annemie Van der Linden³, George Kollias⁴, Rik J. Lories⁵ and Dirk Elewaut⁶, ¹Dept of Rheumatology, Laboratory for Molecular Immunology and Inflammation, Ghent University, Ghent, Belgium, ²Dept of Physics and Astronomy, UGCT, Ghent University, Ghent, Belgium, ³Bio-imaging Lab, University of Antwerp, Antwerp, Belgium, ⁴Institute of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, ⁵Dept of Development and Regeneration, Laboratory for Skeletal Development and Joint Disorders, KU Leuven, Leuven, Belgium, ⁶Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium
Background/Purpose: Spondyloarthritides (SpA) are characterised by both peripheral and axial arthritis. Hallmarks of peripheral SpA are the development of enthesitis, most typically of the Achilles…