Abstracts tagged "enthesis"

Abstract Number: 2397 • 2018 ACR/ARHP Annual Meeting
The Impact of Adalimumab on Growth in Patients with Pediatric Enthesitis-Related Arthritis
Rubén Burgos-Vargas¹, Shirley M.L. Tse², Kirsten Minden³, Pierre Quartier⁴, Jaclyn K. Anderson⁵, Kristina Unnebrink⁶, Ivan Lagunes Galindo⁵ and Gerd Horneff⁷, ¹Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, ²The Hospital for Sick Children, Toronto, ON, Canada, ³Charite University Medicine, Berlin, Germany, ⁴Hopital Necker-Enfants Malades, Paris, France, ⁵AbbVie Inc., North Chicago, IL, ⁶AbbVie Deutschland GmbH & Co., Ludwigshafen, Germany, ⁷Asklepios Clinic Sankt Augustin, and University Hospital of Cologne, Cologne, Germany
Background/Purpose: Children with one or more subtypes of juvenile idiopathic arthritis, such as enthesitis-related arthritis (ERA), often exhibit growth impairments. The purpose of the analysis…
Abstract Number: 1830 • 2018 ACR/ARHP Annual Meeting
Role of BMP2 in Entheseal Bone Formation in Inflammatory Arthritis
Yukiko Maeda¹, Jozsef Karman² and Ellen M. Gravallese³, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Abbvie Bioresearch Center, Worcester, MA, ³Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Spondyloarthritis (SpA) is common, with a prevalence of ~1% in the United States. Patients with SpA suffer from pain and disability due to inflammation…
Abstract Number: 639 • 2017 ACR/ARHP Annual Meeting
Clinical and Sonographic Analysis of Patients with Psoriasis without Musculoskeletal Complaints. Preeliminary Results of a Prospective Study: The PRE-Psa Cohort
Andrea Cuervo¹, Julio Ramírez², Merce Alsina³, Raimon Sanmarti⁴ and Juan D. Cañete⁵, ¹Arthritis Unit. Rheumatology Dpt, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ²Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, ³Dermatology Dpt, Hospital Clinic de Barcelona, Barcelona, Spain, ⁴Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona, Barcelona, Spain, ⁵Arthritis Unit. Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona, Barcelona, Spain
Background/Purpose: Early diagnosis in psoriatic arthritis (PsA) is mandatory in order to initiate early therapy and prevent disability. Around 20% of patients with Psoriasis (PsO)…
Abstract Number: 661 • 2017 ACR/ARHP Annual Meeting
Normal Human Enthesis Contains a Resident Population of γδT-Cells
Richard Cuthbert¹, Evangelos M. Fragkakis¹, Robert Dunsmuir², Peter Giannoudis³, Elena Jones¹, Darren Newton⁴ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom, ³Academic Department of Trauma and Orthopaedics, University of Leeds, Leeds, United Kingdom, ⁴Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Background/Purpose: Recent animal studies have suggested that γδT-cells accumulate at enthesis, secrete IL-17 and are responsible for driving the spondyloarthritis (SpA) phenotype resulting from IL-23…
Abstract Number: 1978 • 2016 ACR/ARHP Annual Meeting
Differential Pattern of Doppler Signals at Lower Extremity Entheses of Healthy Children
Johannes Roth¹, Sara Stinson² and Luca Di Geso³, ¹Pediatric Rheumatology, Children's Hospital Eastern On, Ottawa, ON, Canada, ²Pediatric Rheumatology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, ³Department of Internal Medicine Ospedale Madonna del Soccorso, San Benedetto del Tronto, Italy
Background/Purpose: Musculoskeletal ultrasound (MSUS) can enhance the clinical assessment of the pediatric enthesis. Doppler signals in particular are considered a sign of pathology but may…
Abstract Number: 2742 • 2016 ACR/ARHP Annual Meeting
How Are Enthesitis, Dactylitis and Nail Involvement Measured and Reported in Recent Clinical Trials of Psoriatic Arthritis (PsA)? a Systematic Literature Review
Sofia Ramiro¹, Josef Smolen², RBM Landewé³, Désirée van der Heijde⁴ and Laure Gossec⁵, ¹Leiden University Medical Center, Leiden, Netherlands, ²Internal Medicine III, Div. of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Paris 06 University and AP-HP, Hôpital Pitié Salpêtrière, Paris, France
Background/Purpose: Enthesitis, dactylitis and nail involvement are part of the core set of domains to be reported in trials of PsA. However, no specific instruments…
Abstract Number: 3037 • 2016 ACR/ARHP Annual Meeting
Calprotectin Is Highly Upregulated in Inflamed Axial Entheses in SKG Mice
Zheni Stavre¹, Yukiko Maeda² and Ellen M. Gravallese³, ¹Internal Medicine-Rheumatology, University of Massachusetts Medical School, Worcester, MA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: SKG mice exhibit features of spondyloarthropathy (SpA) and inflammatory bowel disease (IBD). Their SpA-like phenotype is induced by a beta-glucan, curdlan, via the Dectin-1…
Abstract Number: 201 • 2015 ACR/ARHP Annual Meeting
Innate Lymphoid Cells Are Present at Normal Human Enthesis Providing a Potential Mechanism for Spondyloarthropathy Pathogenesis
Richard Cuthbert¹, Evangelos M. Fragkakis¹, Peter Millner², Robert Dunsmuir², Yasser El-Sherbiny¹ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom
Background/Purpose: The pathogenesis of murine spondyloarthropathy (SpA) has been intimately linked to the presence of IL-23 responsive, innate like lymphocytes at peripheral and spinal enthesis.…
Abstract Number: 2418 • 2015 ACR/ARHP Annual Meeting
Pediatric Enthesitis-Related Arthritis: Variation in Disease Characteristics and Treatments Among 5 Large Centers
Sabrina Gmuca¹, Timothy Brandon², Rui Xiao³, Ilaria Pagnini⁴, Tracey B. Wright⁵, Timothy Beukelman⁶, Esi Morgan-DeWitt⁷ and Pamela F. Weiss⁸, ¹Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, ³Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ⁴Department of Paediatrics, University of Florence and Anna Meyer Children's Hospital, Florence, Italy, Florence, Italy, ⁵Pediatrics/Rheumatology, Univ of TX Southwestern, Dallas, TX, ⁶Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷Pediatric rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: We aimed to compare the clinical features and treatments of children with Enthesitis-related arthritis (ERA) from 5 pediatric rheumatology centers in order to determine…
Abstract Number: 2594 • 2014 ACR/ARHP Annual Meeting
Differences in Localization and Activity of the Entheseal Involvement Between Non-Radiographic and Radiographic Axial Spondyloarthritis By the Ultrasound Assessment
Marketa Fojtikova¹, Karel Pavelka¹, Sarka Forejtova² and Jindra Gatterova³, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²Rheumatology, Institute of Rheumatology, Prague, Czech Republic, ³Institute of rheumatology, Prague 2, Czech Republic
Background/Purpose Inflammatory involvement of peripheral enthesis belongs to an important sign of spondyloarthritis (SpA). It may occur in patients with long-term as well as newly…
Abstract Number: 1917 • 2014 ACR/ARHP Annual Meeting
IL-23 Expression and Activation of Autophagy in Synovium and PBMCs of HLA-B27 Positive Patients with Ankylosing Spondylitis
Barbara Neerinckx, Shea Carter and Rik J. Lories, Laboratory of Tissue Homeostasis and Disease - SBE Research Center, KU Leuven, Leuven, Belgium
Background/Purpose: IL-23 may play a key role in the pathogenesis of ankylosing spondylitis (AS). Some studies describe indeed increased serum levels of IL-23 in AS…
Abstract Number: 141 • 2014 ACR/ARHP Annual Meeting
Prevalence of Subclinical Enthesopathy in Asymptomatic First Degree Relatives of Patients with Spondyloarthritis
Tomas Cazenave¹, Natalia Zamora², Marcelo Audisio^3,4, Ana M. Bertoli⁵, Guillermo Py⁶, Walter Spindler⁷, Javier Rosa⁸, David A. Navarta⁹, Teresita de Alvarellos¹⁰, Luciana Mas¹¹, Gustavo Citera¹² and Marcos G. Rosemffet¹³, ¹Junin 519 1ero B, IREP, Buenos Aires, Argentina, ²IREP, Echeverría 955, Buenos Aires, Argentina, ³DEH, Córdoba, Argentina, ⁴Bedoya 650 Bº Alta Córdoba, Servicio de Reumatología del Hospital Nacional de Clínicas, Córdoba., Cordoba, Argentina, ⁵Instituto Reumatológico Strusberg, Cordoba, Cordoba, Argentina, ⁶Servicio de Reumatología del Hospital Nacional de Clínicas, Córdoba., Cordoba, Argentina, ⁷Centro Médico Privado de Reumatología, Tucumán, Argentina, ⁸Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁹Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ¹⁰Hospital Privado de Córdoba, Córdoba, Argentina, ¹¹Laboratorio de Histocompatibilidad, Hospital Privado Centro Medico De Córdoba, Cordoba, Argentina, ¹²Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ¹³Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina
Background/Purpose There are no studies evaluating enthesis involvement detected by US in relatives of spondyloarthritis (SpA) patients. Objectives: 1) To evaluate and compare the prevalence…
Abstract Number: 140 • 2014 ACR/ARHP Annual Meeting
Are Entheses Ultrasound Findings Similar in Axial Spa Patients and in Athletes?
Marie-Alix Lanfranchi¹, Olivier Leluc², Alice Tavano³, Vincent Pradel⁴, Sophie Morange⁵, Christophe Chagnaud³, Pierre Lafforgue¹ and Thao Pham¹, ¹Rheumatology, APHM, Aix Marseille University, Marseille, France, ²Rheumatology, APHM, Marseille, France, ³Radiology, APHM, Aix Marseille University, Marseille, France, ⁴Epidemiology, APHM, Aix Marseille University, Marseille, France, ⁵Center for Clinical Investigation, APHM, Aix Marseille University, Marseille, France
Background/Purpose Spondyloarthritis (SpA) are characterized by inflammatory and structural changes in the entheses (enthesitis). However, enthesitis is not only observed in SpA and can also…

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