ACR Meeting Abstracts

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Abstracts tagged "endothelial cells and systemic sclerosis"

  • Abstract Number: 772 • 2017 ACR/ARHP Annual Meeting

    Molecular Mechanism for the Therapeutic Effect of Extracorporeal Shock Wave Therapy on Digital Ulcers of Systemic Sclerosis

    Yukiko Kamogawa1, Hiroshi Fujii1, Tsuyoshi Shirai1, Tomonori Ishii2 and Hideo Harigae1, 1Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 2Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan

    Background/Purpose: Digital ulcers (DUs) are the most common skin manifestations in systemic sclerosis (SSc). DUs in SSc are not usually caused by vasculitis and are…
  • Abstract Number: 821 • 2015 ACR/ARHP Annual Meeting

    Elevated Serum Levels of Soluble CD146 in Patients with Systemic Sclerosis

    Kazunori Kato1, Tomoko Ito2, Naoto Tamura2, Sayuri Okuda1, Masakazu Matsushita2, Kurisu Tada2, Ken Yamaji2 and Yoshinari Takasaki2, 1Department of Biomedical Engineering, Toyo University, Saitama, Japan, 2Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: CD146 is a transmembrane glycoprotein belonging to Ig-superfamily. Human endothelial cells, activated fibroblasts and Th17 cells express CD146 that involved in angiogenesis, fibrosis and…
  • Abstract Number: 700 • 2012 ACR/ARHP Annual Meeting

    Clinical Correlation of Flow-Mediated Endothelium-Dependent Vasodilatation in Systemic Sclerosis

    Takehiro Takahashi1, Yoshihide Asano1, Eisuke Amiya2, Masaru Hatano3, Atsuko Ozeki2, Aya Watanabe2, Shuichi Kawarasaki2, Tomoko Nakao2, Zenshiro Tamaki4, Takashi Taniguchi5, Yohei Ichimura5, Tetsuo Toyama1, Masafumi Watanabe6, Yasunobu Hirata2, Ryozo Nagai3 and Shinichi Sato7, 1Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 3Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 4Medicine, Rheumatology, Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 5Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 6Cardiovascular Medicine, Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 7Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by initial vascular injuries and resultant fibrosis of skin and certain internal organs. Evidence has…
  • Abstract Number: 699 • 2012 ACR/ARHP Annual Meeting

    Endothelial Dysfunction and Vascular Stiffness in Early Diffuse Systemic Sclerosis

    Robyn T. Domsic1, Dana Ivanco2, Hunter C. Champion3, Ali Shoushtari3 and Thomas A. Medsger Jr.4, 1Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 2Department of Medicine/Div. of Rheumatology, University of Pittsburgh, Pittsburgh, PA, 3Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 4Medicine/Rheumatology, Univ of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Vascular dysfunction is a hallmark of systemic sclerosis (SSc).  Current theories postulate endothelial injury and dysfunction as an early event in SSc pathogenesis.   Prior…
  • Abstract Number: 1494 • 2012 ACR/ARHP Annual Meeting

    CD40 Signaling Results in Microvascular Endothelial Dysfunction: A Possible Clue to the Pathogenesis of Scleroderma Vasculopathy

    Bashar Kahaleh1 and Yongqing Wang2, 1Medicine/Rheumatology, University of Toledo, Toledo, OH, 2Medicine, University of Toledo, Toledo, OH

    Background/Purpose: Increased expression of CD40 in SSc- Microvascular Endothelial Cells (MVEC) was noted on a gene expression array and increased concentrations of soluble CD40 ligand (sCD40L)…
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