Abstracts tagged "endothelial cells and systemic sclerosis"

Abstract Number: 772 • 2017 ACR/ARHP Annual Meeting
Molecular Mechanism for the Therapeutic Effect of Extracorporeal Shock Wave Therapy on Digital Ulcers of Systemic Sclerosis
Yukiko Kamogawa¹, Hiroshi Fujii¹, Tsuyoshi Shirai¹, Tomonori Ishii² and Hideo Harigae¹, ¹Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, ²Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan
Background/Purpose: Digital ulcers (DUs) are the most common skin manifestations in systemic sclerosis (SSc). DUs in SSc are not usually caused by vasculitis and are…
Abstract Number: 821 • 2015 ACR/ARHP Annual Meeting
Elevated Serum Levels of Soluble CD146 in Patients with Systemic Sclerosis
Kazunori Kato¹, Tomoko Ito², Naoto Tamura², Sayuri Okuda¹, Masakazu Matsushita², Kurisu Tada², Ken Yamaji² and Yoshinari Takasaki², ¹Department of Biomedical Engineering, Toyo University, Saitama, Japan, ²Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: CD146 is a transmembrane glycoprotein belonging to Ig-superfamily. Human endothelial cells, activated fibroblasts and Th17 cells express CD146 that involved in angiogenesis, fibrosis and…
Abstract Number: 700 • 2012 ACR/ARHP Annual Meeting
Clinical Correlation of Flow-Mediated Endothelium-Dependent Vasodilatation in Systemic Sclerosis
Takehiro Takahashi¹, Yoshihide Asano¹, Eisuke Amiya², Masaru Hatano³, Atsuko Ozeki², Aya Watanabe², Shuichi Kawarasaki², Tomoko Nakao², Zenshiro Tamaki⁴, Takashi Taniguchi⁵, Yohei Ichimura⁵, Tetsuo Toyama¹, Masafumi Watanabe⁶, Yasunobu Hirata², Ryozo Nagai³ and Shinichi Sato⁷, ¹Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁴Medicine, Rheumatology, Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁵Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁶Cardiovascular Medicine, Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁷Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by initial vascular injuries and resultant fibrosis of skin and certain internal organs. Evidence has…
Abstract Number: 699 • 2012 ACR/ARHP Annual Meeting
Endothelial Dysfunction and Vascular Stiffness in Early Diffuse Systemic Sclerosis
Robyn T. Domsic¹, Dana Ivanco², Hunter C. Champion³, Ali Shoushtari³ and Thomas A. Medsger Jr.⁴, ¹Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Department of Medicine/Div. of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine/Rheumatology, Univ of Pittsburgh, Pittsburgh, PA
Background/Purpose: Vascular dysfunction is a hallmark of systemic sclerosis (SSc). Current theories postulate endothelial injury and dysfunction as an early event in SSc pathogenesis. Prior…
Abstract Number: 1494 • 2012 ACR/ARHP Annual Meeting
CD40 Signaling Results in Microvascular Endothelial Dysfunction: A Possible Clue to the Pathogenesis of Scleroderma Vasculopathy
Bashar Kahaleh¹ and Yongqing Wang², ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: Increased expression of CD40 in SSc- Microvascular Endothelial Cells (MVEC) was noted on a gene expression array and increased concentrations of soluble CD40 ligand (sCD40L)…