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Abstracts tagged "endothelial cells and systemic lupus erythematosus (SLE)"

  • Abstract Number: 2096 • ACR/ARHP Annual Meeting 2018

    Ectonucleotidase CD73 Suppresses Autoantibody Production and Arterial Vasculopathy in Murine Lupus

    Ramadan A. Ali1, Nicole R. Pearce1, Srilakshmi Yalavarthi1, Kevin B. Atkins1, Alex A. Gandhi1, Yogendra Kanthi1 and Jason S. Knight2, 1University of Michigan, Ann Arbor, MI, 2., University of Michigan, Ann Arbor, MI

    Background/Purpose: CD73 is a surface nucleotidase that extends into the extracellular space where it generates adenosine from AMP. By regulating a cell’s “purinergic halo,” CD73…
  • Abstract Number: 2642 • ACR/ARHP Annual Meeting 2017

    Lupus Serum Induces Glomerular Endothelial Cell Neutrophil Adhesion in Association with Soluble Mediators of Chemotaxis and Adhesion

    Dayvia Russell1, Margaret Markiewicz2 and Jim C. Oates3,4, 1Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC, 2Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 3Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 4Medical Service, Ralph H. Johnson VA Medical Center, Charleston, SC

    Background/Purpose: Systemic lupus erythematosus (SLE) is associated with endothelial dysfunction, which can accelerated inflammation. Ingress of neutrophils into tissue requires chemotaxis and adhesion to endothelial…
  • Abstract Number: 641 • ACR/ARHP Annual Meeting 2013

    Vitamin D Increases The Number and Function Of Myeloid Angiogenic Cells In Systemic Lupus Erythematosus

    John A. Reynolds1, David W. Ray2, Terence O'Neill3, M. Yvonne Alexander4 and Ian N. Bruce5, 1Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, 2Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, 3Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, 4Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, 5Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) have an increased prevalence of cardiovascular disease (CVD).  Vitamin D deficiency is common in SLE and an independent…
  • Abstract Number: 584 • ACR/ARHP Annual Meeting 2013

    The Effect Of Ramipril On Endothelial Function and Endothelial Progenitor Cells In Patients With Systemic Lupus Erythematosus

    Emilia I. Sato1, Luiz Samuel G. Machado2 and Ana Cecilia Machado3, 1Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, 2Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil, 3Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

    Background/Purpose: Cardiovascular diseases (CVD) are one of major causes of morbidity and mortality in SLE patients. Traditional cardiovascular risk factors and disease intrinsic factors contribute…

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