Abstracts tagged "endothelial cells and rheumatoid arthritis (RA)"

Abstract Number: 1652 • 2016 ACR/ARHP Annual Meeting
Basement Membrane Remodeling Is Significantly Increased with Rheumatoid Arthritis and Suppressed By IL6 Inhibition: Analysis of Two Phase III Clinical Trial
Natasja Stæhr Gudman¹, Pernille Juhl², Christian S. Thudium³, Anne Sofie Siebuhr⁴, Inger Byrjalsen⁵, Morten Asser Karsdal⁴ and Anne C. Bay-Jensen⁴, ¹Nordic Bioscience A/S, Herlev, Denmark, ²Biomarkers & Research, Nordic Bioscience, Herlev, Denmark, ³Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁴Rheumatology, Nordic Bioscience, Herlev, Denmark, ⁵Nordic Bioscience, Clinical Development, Herlev, Denmark
Background/Purpose: Rheumatoid arthritis (RA) is associated with neovascularization of the synovial membrane and increased risk of cardiovascular disease, consequent to vascular and endothelial dysfunction, which…
Abstract Number: 3009 • 2014 ACR/ARHP Annual Meeting
Stem Cell Augmentation for Cardiovascular Risk in Rheumatoid Arthritis
Nidhi Garg¹, Ashit Syngle² and Pawan Krishan¹, ¹Deptt. of Pharmaceutical Sciences & Drug Research, Punjabi University Patiala, India, Patiala, India, ²Cardio Rheuma, Healing Touch City Clinic, Fortis Multispeciality Hospital, Chandigarh, India
Background/Purpose: Bone marrow derived stem cells, endothelial progenitor cells (EPCs), protect against atherosclerotic vascular damage by overcoming endothelial damage. However, EPCs are depleted in RA…
Abstract Number: 1957 • 2014 ACR/ARHP Annual Meeting
Dysregulation of CC Chemokines at Microvascular Endothelial Cells of Blood and Lymphatic Vessels Under Inflammatory Conditions
Lisa Rump-Goodrich¹, Ayman Askari², Derek Mattey³ and Jim Middleton⁴, ¹Arthritis Research centre, Keele University, Gobowen, United Kingdom, ²Rheumatology, Robert Jones and Agnes Orthopaedic Hospital, Gobowen, United Kingdom, ³Keele University, Stoke-on-Trent, United Kingdom, ⁴Bristol university, Bristol, United Kingdom
Background/Purpose: Inflammation in the rheumatoid arthritis (RA) synovium is directly associated with inflammatory cell migration across microvasculature endothelial cells (ECs), and their persistence within the…
Abstract Number: 2415 • 2013 ACR/ARHP Annual Meeting
Phosphorylated Venous Endothelial Nitric Oxide Synthase Is Elevated In Rheumatoid Arthritis Subjects With High Disease Activity
Elizabeth Blair Solow¹, Wanpen Vongpatanasin² and David R. Karp³, ¹Rheumatology, UT Southwestern Medical Center, Dallas, TX, ²Cardiology, UT Southwestern Medical Center, Dallas, TX, ³Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX
Background/Purpose: Endothelial dysfunction is present in arthritis animal models and rheumatoid arthritis (RA), a population known to develop premature cardiovascular disease. Previous studies indicate inflammation…
Abstract Number: 1777 • 2012 ACR/ARHP Annual Meeting
The Bioenergetic Role of HIF-1 and HIF-2 During Angiogenesis of Human Microvascular Endothelial Cells
Martin Hahne¹, Cindy Strehl¹, Manuela Jakstadt¹, Paula Hoff¹, Timo Gaber¹, Gerd Burmester¹ and Frank Buttgereit², ¹Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ²Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Hypoxia and angiogenesis are features of inflamed and injured tissues. The transcription factors Hypoxia inducible factor (HIF)-1 and (HIF)-2 control cellular metabolic response to…

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