ACR Meeting Abstracts

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Abstracts tagged "endothelial cells and interferons"

  • Abstract Number: 2429 • 2016 ACR/ARHP Annual Meeting

    Mechanisms for the Development of Lung Fibrosis in Sting-Associated Vasculopathy with Onset in Infancy (SAVI)

    Adriana Almeida de Jesus1, Louise Malle1, Dan Yang2, Bernadette Marrero1, Yin Liu3, Gina A. Montealegre Sanchez1, Dawn C. Chapelle4, Hanna Kim4, Michelle O'Brien4, Gregor Dueckers5, Suzanne Ramsey6, Joseph R. Fontana7, Steven M. Holland8, Yan Huang1, Suvimol Hill9, Laisa Santiago10, Benito Gonzalez11, Paul Brogan12, Juergen Brunner13, Ebun Omoyinmi14, Athimalaipet V Ramanan15, Amy Paller16, Olcay Y. Jones17, Seza Ozen18, Stephen Brooks4, Zuoming Deng4, Manfred Boehm19, Raphaela Goldbach-Mansky20 and Helmut Wittkowski21, 1National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, 2National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, 3Scientific Review Branch, NIAMS, NIH, Bethesda, MD, 4NIAMS/NIH, Bethesda, MD, 5Helios Kliniken - Kinderklinik, HELIOS Klinikum Krefeld, Krefeld, Germany, 6Pediatric Rheumatology, IWK Health Centre, Halifax, NS, Canada, 7Cardiovascular and Pulmonary Branch, NHLBI, NIH, Bethesda, MD, 8Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, MD, 9Radiology Department, Clinical Center, NIH, Bethesda, MD, 10Johns Hopkins All Children's Hospital Rheumatology, Saint Petersburg, FL, 11Luis Calvo Mackenna Hospital, Santiago, Chile, 12UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 13Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria, 14University College London Institute of Child Health, London, United Kingdom, 15University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom, 16Departments of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;, Chicago, IL, 17Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, 18Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, ANKARA, Turkey, 19Laboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, 20Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, 21Department of Pediatric Rheumatology and Immunology, University Hospital of Muenster, Münster, Germany

    Background/Purpose:  STING-Associated Vasculopathy with Onset in Infancy (SAVI) is a monogenic autoinflammatory interferonopathy caused by gain-of-function mutations in TMEM173/STING, a nucleic acid sensor adaptor linked…
  • Abstract Number: 2003 • 2015 ACR/ARHP Annual Meeting

    Primary Antiphospholipid Syndrome Is Characterized By Endothelial Progenitor Dysfunction and a Type I Interferon Signature

    Robert C. Grenn1, Srilakshmi Yalavarthi2, Paula L. Bockenstedt3 and Jason S. Knight2, 1University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI, 3Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI

    Background/Purpose:  Patients with primary antiphospholipid syndrome (APS) are at risk for endothelial dysfunction and accelerated atherosclerosis.  In systemic lupus erythematosus (SLE), there is a well-established…
  • Abstract Number: 681 • 2012 ACR/ARHP Annual Meeting

    Interferon Alpha Decreases Endothelial Nitric Oxide Synthase Function and Expression in Human Umbilical Vein Endothelial Cells

    Joy Buie1 and Jim Oates2, 1Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 2Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Premenopausal SLE patients have a devastating increase in cardiovascular disease (CVD) and major associated cardiovascular events (MACE) that are not fully explained by Framingham…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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