Abstracts tagged "endothelial cells and antiphospholipid antibodies"

Abstract Number: 19 • ACR/ARP Annual Meeting 2019
Inhibition of IkB Kinase-IKK Complex of Canonical NF-κB Pathway in Antiphospholipid Antibody-Mediated Endothelial Cell Activation
Rohan Willis¹, Elizabeth Papalardo ¹, Mohammad Jamaluddin ¹, Zurina Romay-Penabad ¹, Alvaro Schleh ¹, Allan Brasier ¹ and Emilio B Gonzalez ², ¹University of Texas Medical Branch, Galveston, TX, ²University of Texas Medical Branch, Galveston
Background/Purpose: Antiphospholipid antibodies (aPL) activate several target cell types leading to inflammatory damage and thrombosis in the antiphospholipid syndrome (APS). NF-κB activation is essential for…