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Abstracts tagged "ellis van creveld and cartilage"

  • Abstract Number: 1979 • ACR/ARP Annual Meeting 2019

    What Is the Pathogenic Meaning of Chondrocyte Hypertrophy in Osteoarthritis? Effect of Evc Deletion Through Hedgehog Signaling

    Ana Lamuedra1, Paula Gratal 1, Víctor Luis Ruiz-Perez 2, Adrián Palencia-Campos 3, Sergio Portal-Nuñez 4, Gabriel Herrero-Beaumont 5 and Raquel Largo 5, 1IIS - Fundacion Jimenez Diaz, Madrid, Madrid, Spain, 2Instituto de Investigaciones Biomédicas 'Alberto Sols', Madrid, Madrid, Spain, 3Adrián Palencia Campos [[email protected]], Madrid, Madrid, Spain, 4Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, Alcorcón, Madrid, Spain, 5IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain

    Background/Purpose: Osteoarthritis (OA) is mainly characterized by the progressive damage of articular cartilage, where chondrocytes acquire a hypertrophic-like phenotype. Indian Hedgehog levels are increased in…
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