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Abstracts tagged "Early Rheumatoid Arthritis"

  • Abstract Number: 1266 • 2016 ACR/ARHP Annual Meeting

    Predictors of Radiographic Progression in Early Rheumatoid Arthritis Patients Treated By an Aggressive Treat-to-Target Regimen

    Nina P. Sundlisater1, Siri Lillegraven1, Inge C Olsen1, Anna-Birgitte Aga1, Till Uhlig1, Hilde B. Hammer2, D van der Heijde1,3, Tore K. Kvien1, Espen Haavardsholm1 and ARCTIC study group, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, 3Dept of Rheumatology, Leiden University Medical Ctr, Leiden, Netherlands

    Background/Purpose: With implementation of tight control strategies and defined treatment targets in rheumatoid arthritis (RA) care, a majority of early RA patients may reach remission…
  • Abstract Number: 2987 • 2016 ACR/ARHP Annual Meeting

    Comparison of Certolizumab Pegol Versus Adalimumab: 2 Year Efficacy and Safety Results from a Superiority, Investigator-Blind, Head-to-Head Study

    Roy Fleischmann1, Gerd-Rüdiger Burmester2, Bernard Combe3, Jeffrey R. Curtis4, Stephen Hall5, Boulos Haraoui6, Ronald van Vollenhoven7, Christopher Cioffi8, Cécile Ecoffet9, Lucian Ionescu9, Leon Gervitz10, Luke Peterson8 and Josef Smolen11, 1University of Texas Southwestern Medical Center at Dallas Metroplex Clinical Research Center, Dallas, TX, 2Charité – University Medicine Berlin, Berlin, Germany, 3Montpellier University Hospital, Montpellier, France, 4Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 5Cabrini Medical Centre, Monash University, Melbourne, Australia, 6Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada, 7Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam, Netherlands, 8UCB Pharma, Raleigh, NC, 9UCB Pharma, Brussels, Belgium, 10RA Patient Value Mission, UCB Pharma, Brussels, Belgium, 11Medical University of Vienna and Hietzing Hospital, Vienna, Austria

    Background/Purpose: Head-to-head comparisons of biological (b)DMARDs in the treatment of RA should provide rigorous evidence on the comparative efficacy of different treatments. Although there are…
  • Abstract Number: 153 • 2016 ACR/ARHP Annual Meeting

    Synovial Immunophenotype and Ultrasonography: A Contemporaneous Study of Different Compartments of the Knee Joint

    Aurélie Najm1,2, Carl Orr3, Benoît Le Goff MD PhD1, Ursula Fearon4 and Douglas J. Veale5, 1Rheumatology, Nantes University Hospital, Nantes, France, 2Rheumatology, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, 3Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, 4Trinity College Dublin, Department of Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland, 5Consultant Rheumatologist, Centre for Arthritis and Rheumatic Disease, St. Vincent’s University Hospital and University College Dublin, Dublin 4, Ireland

    Background/Purpose: Histological analysis of synovial tissue, despite being a reliable and accurate assessment for synovitis, is not routinely performed. Ultrasonography (US) is a fast, available…
  • Abstract Number: 1271 • 2016 ACR/ARHP Annual Meeting

    Plasma Concentration of S100A8/A9 Proteins Is an Independent Biomarker for Radiological Progression in in Early Rheumatoid Arthritis

    Maxime Chevreau1, Marie Helène Paclet2, Jean-Louis Quesada3, Marine Clay4, Philippe Dieudé5,6, Olivier Vittecoq7, Philippe Gaudin8 and Athan Baillet9, 1Rheumatology, CHU Sud Hospital, Grenoble, France, 2IPB _ Grenoble teaching hospital, Grenoble, France, 3Grenoble University Hospital, France, Grenoble, France, Grenoble, France, 4Rheumatology Grenoble, Grenoble, France, 5Rheumatology, Bichat hospital APHP, Paris, France, 6Rheumatology, Hôpital Bichat, Paris, France, 7Rheumatology, Rouen University Hospital &INSERM U905, Rouen, France, 8Grenoble University Hospital, France, Grenoble, France, 9Rheumatology, Grenoble University Hospital, France, Echirolles, France

    Background/Purpose: Increasing body of evidence suggest that alarmins such as S100A8/A9 proteins play a critical role in Rheumatoid Arthritis pathogenesis (RA). We aimed to analyze…
  • Abstract Number: 3150 • 2016 ACR/ARHP Annual Meeting

    The Initial Dose of Methotrexate per Weight Is Determinant of Disease Activity and Early DAS28 Remission in DMARD-Naive Early Rheumatoid Arthritis Patients Receiving Usual Care

    Tuomas Rannio1, Juha Asikainen2, Pekka Hannonen2, Timo Yli-Kerttula3, Päivi Ekman4, Laura Kuusalo5, Laura Pirilä6, Markku Mali7, Marja Puurtinen-Vilkki7, Satu Kortelainen7, Johanna Paltta6, Kirsi Taimen7, Markku J. Kauppi8, Kari Laiho9, Satu Nyrhinen9, Heidi Mäkinen10, Pia Isomäki10, Terhi Uotila10, Kalle Aaltonen11, Hannu Kautiainen12 and Tuulikki Sokka-Isler1, 1Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, 2Jyvaskyla Central Hospital, Jyväskylä, Finland, 3Sairaalantie 3, Satakunta Central Hospital, Rauma, Finland, 4Satakunta Central Hospital, Rauma, Finland, 5Rheumatology, Turku University Central Hospital, Turku, Finland, 6Turku University Hospital, Turku, Finland, 7Turku University Central Hospital, Turku, Finland, 8Department of Rheumatology, Päijät-Häme Central Hospital, Lahti, Finland, 9Päijät-Häme Central Hospital, Lahti, Finland, 10Tampere University Hospital, Tampere, Finland, 11Helsinki University, Helsinki, Finland, 12Unit of Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

      Background/Purpose: Methotrexate (MTX) is considered as the anchor disease modifying antirheumatic drug (DMARD) in treatment of rheumatoid arthritis (RA). However, there is no advice…
  • Abstract Number: 163 • 2016 ACR/ARHP Annual Meeting

    Fluorescence Optical Imaging Reveals Distinct Patterns of Hand Joint Inflammation in Seropositive and Seronegative Early Rheumatoid Arthritis

    Yogan Kisten1, Erik af Klint2, Hamed Rezaei2,3, Adrian Levitsky4, Per T Larsson2, Anna Karlsson2,3, Noémi Györi1, Ronald F. van Vollenhoven1,5 and Laurent Arnaud3, 1Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, 2Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 3Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, 4Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, 5Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam, Netherlands

    Background/Purpose: Detection of abnormal Rheumatoid Arthritis (RA) related autoantibodies, Rheumatoid Factor (RF) and Anti- Citrullinated Peptide Antibody (ACPA), along with musculoskeletal ultrasound (MSUS) plays a…
  • Abstract Number: 1274 • 2016 ACR/ARHP Annual Meeting

    The Reproducibility of a Semi-Automatic Algorithm in the Detection of Cortical Breaks and Adjacent Trabecular Bone Loss in Scan-Rescan Data from Patients with Early Arthritis

    M. Peters1, J. de Jong2, A. Scharmga1, A. van Tubergen1, D. Loeffen3, R. Weijers3, B. van Rietbergen4, Steven K. Boyd5, Cheryl Barnabe6, Kathryn S. Stok7, Piet Geusens8 and J. van den Bergh9, 1Department of Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2Maastricht University, Maastricht, Netherlands, 3Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 4Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 5Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 6Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 7Institute for Biomechanics, ETH Zurich, Zurich, Switzerland, 8Maastricht University Hospital, Maastricht, Netherlands, 9Internal Medicine, Viecuri Medical Center, Venlo, Netherlands

    Background/Purpose: In RA bone erosions are defined as cortical breaks with adjacent trabecular bone loss. High resolution peripheral quantitative CT (HR-pQCT) is more sensitive than…
  • Abstract Number: 3153 • 2016 ACR/ARHP Annual Meeting

    Automated Cell Phone Monitoring of Disease Activity and Medication Adherence in Early Rheumatoid Arthritis

    Laura Kuusalo1,2, Hannu Kautiainen3, Tuulikki Sokka-Isler4, Toini Uutela5, Laura Pirilä2, Timo Yli-Kerttula6, Markku J Kauppi7,8, Tuomas Rannio9, Kirsi Paalanen10, Arto Kokko9, Juha Asikainen9, Jelena Borodina10, Johanna Paltta2, Kari Laiho11, Andrus Mullanmaa12, Kari Puolakka12 and SandRA Study Group, 1University of Turku, Turku, Finland, 2Turku University Hospital, Turku, Finland, 3Unit of Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, 4Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, 5Lapland Central Hospital, Rovaniemi, Finland, 6Sairaalantie 3, Satakunta Central Hospital, Rauma, Finland, 7School of Medicine, University of Tampere, Tampere, Finland, 8Department of Rheumatology, Päijät-Häme Central Hospital, Lahti, Finland, 9Jyvaskyla Central Hospital, Jyväskylä, Finland, 10Jyvaskyla Central Hospital, Jyvaskyla, Finland, 11Päijät-Häme Central Hospital, Lahti, Finland, 12South Karelia Central Hospital, Lappeenranta, Finland

    Background/Purpose: Remission targeted treatment of early RA requires frequent monitoring. However, in clinical practice monitoring frequency is not always optimal due to factors like limited…
  • Abstract Number: 185 • 2016 ACR/ARHP Annual Meeting

    The Interferon Gene Signature Is Increased in Early DMARD Naive Rheumatoid Arthritis and Predicts a Poorer Response to Initial Therapy

    Faye A H Cooles1, Amy E. Anderson1, Dennis W Lendrem1, Julie Norris1, Arthur G. Pratt1, Catharien M U Hilkens2 and John D Isaacs3, 1Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, 2Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom, 3Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom

    Background/Purpose: Type 1 interferons, such as interferon-α, are of increasing interest in autoimmunity due to their pleiotropic effects on the immune system.  Approximately 20-30% of…
  • Abstract Number: 1300 • 2016 ACR/ARHP Annual Meeting

    MRI-Detected Inflammation Is Associated with Functional Disability in Early Arthritis – Results of a Cross-Sectional Study

    Leonie E Burgers1, Wouter P Nieuwenhuis1, Hanna W van Steenbergen1, Elize C Newsum1, Tom WJ Huizinga1, Monique Reijnierse2, Saskia le Cessie3 and Annette HM van der Helm-van Mil1, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Medical statistics and Epidemiology, Department of Medical Statistics and Epidemiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose:  Magnetic resonance imaging (MRI) sensitively detects inflammation, but the clinical relevance of MRI-detected inflammation is undetermined in early arthritis. Therefore, this cross-sectional study investigated…
  • Abstract Number: 3154 • 2016 ACR/ARHP Annual Meeting

    Assessing Bone Erosions in the Metatarsophalangeal Joints of Patients with Early Rheumatoid Arthritis:  a Comparison Between MRI and Ultrasound

    Karen A. Beattie1, Sydney Scheffler2, George Ioannidis3, Edward Schreyer4, Saara Totterman5 and Maggie Larche1, 1Medicine, McMaster University, Hamilton, ON, Canada, 2McMaster University, Hamilton, ON, Canada, 3St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 4QMetrics Technologies, Rochester, NY, 5Radiology, VirtualScopics Inc., Rochester, NY

    Background/Purpose: This cross-sectional study aimed to assess the agreement between Magnetic Resonance Imaging (MRI) and ultrasound (US) findings of bone erosions in the metatarsalphalangeal (MTP)…
  • Abstract Number: 492 • 2016 ACR/ARHP Annual Meeting

    Calprotectin Levels Correlate with Inflammation in Early Rheumatoid Arthritis before Disease-Modifying Antirheumatic Drug Treatment and after 12 Months of Treatment

    Maria K. Jonsson1,2,3, Hilde B. Hammer4, Hilde H. Nordal1,3, Anna-Birgitte Aga2, Inge C Olsen2, Karl Albert Brokstad3, Tore K Kvien2, Bjørg-Tilde Fevang1,5, Siri Lillegraven2, Espen A. Haavardsholm2 and ARCTIC study group, 1Dept. of Rheumatology, Haukeland University Hospital, Bergen, Norway, 2Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Dept. of Clinical Sciences, University of Bergen, Bergen, Norway, 4Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, 5Department of Clinical Science, University of Bergen, Bergen, Norway

    Background/Purpose:  Calprotectin (MRP8/MRP14, S100A8/A9) is a major leukocyte protein previously shown to be associated with disease activity in patients with established rheumatoid arthritis (RA). Some…
  • Abstract Number: 1457 • 2016 ACR/ARHP Annual Meeting

    Early Onset Morbidity and Mortality in Female Tumor Necrosis Factor Transgenic Mice with Inflammatory-Erosive Arthritis and Interstitial Lung Disease

    Richard Bell1, Emily Wu2, Ronald Wood3, Joe Chakkalakal2, Javier Rangel-Moreno4, Maria de la Luz Garcia-Hernandez2, Christopher T. Ritchlin5, Edward Schwarz6 and Homaira Rahimi7, 1Center for Musculoskelatal Research, University of Rochester, Rochester, NY, 2University of Rochaester, Rochester, NY, 3University of Rochester, Rochester, NY, 4Allergy, Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, 5Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, 6Orthopedeatrics, University of Rochester, Rochester, NY, 7Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY

    Background/Purpose: Although exacerbated morbidity and mortality in rheumatoid arthritis (RA) is frequently seen in women, the etiology of this sexual dimorphism remains unclear. Previously, we…
  • Abstract Number: 3209 • 2016 ACR/ARHP Annual Meeting

    Clinical and Radiological Outcomes of 5 Years Remission Steered Treatment in Early Rheumatoid and Undifferentiated Arthritis Patients

    Gülsah Akdemir1, L. Heimans2, R.J. Goekoop3, Maikel van Oosterhout4, J.B. Harbers5, C. Bijkerk6, G.M. Steup-Beekman7, L.R. Lard8, P.B.J. de Sonnaville9, B.A.M. Grillet10, TWJ Huizinga11 and Cornelia F. Allaart2, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Haga Hospital, The Hague, Netherlands, 4Rheumatology, Groene Hart Hospital, Gouda, Netherlands, 5Department of Rheumatology, Franciscus Hospital, Roosendaal, Netherlands, 6Rheumatology, Reinier de Graaf Gasthuis, Delft, Netherlands, 7Rheumatology, Bronovo Hospital, The Hague, Netherlands, 8Rheumatology, MCH Antoniushove Hospital, Leidschendam, Netherlands, 9Rheumatology, ADRZ, Goes, Netherlands, 10Rheumatology, Zorgsaam, Terneuzen, Netherlands, 11Leiden University Medical Centre, Leiden, Netherlands

    Background/Purpose: To assess clinical and radiological outcomes of induction therapy followed by 5 years disease activity score (DAS)-remission steered treatment in early arthritis patients. Methods:…
  • Abstract Number: 501 • 2016 ACR/ARHP Annual Meeting

    Use of Rheumatologic Testing By Primary Care Physicians in Patients with Inflammatory Arthritis

    Dilpreet Singh1, Jasdeep Badwal1, Ritika Vankina1, Santhi Gokaraju2, Jennifer Friderici3, Scott Halista4 and Tara Lagu1, 1Baystate Medical Center/Tufts University School of Medicine, Springfield, MA, 2Presbyterian Hospital of Dallas, Dallas, TX, 3Baystate Medical Center, Springfield, MA, 4Arthritis Treatment Center, Springfield, MA

    Background/Purpose: Anti-cyclic citrullinated peptide antibody (Anti-CCP) is a diagnostic tool that predicts the progression of undifferentiated polyarthritis and erosive disease in rheumatoid arthritis (RA). It…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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