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Abstracts tagged "Early Rheumatoid Arthritis"

  • Abstract Number: 2417 • 2014 ACR/ARHP Annual Meeting

    Is Remission Really Achievable in EARLY Rheumatoid Arthritis?

    Olga Addimanda1, Pierluigi Macchioni2, Andrea Caruso1, Niccolò Possemato1, Mariagrazia Catanoso1 and Carlo Salvarani2, 1S.C. Reumatologia, Arcispedale Santa Maria Nuova, I.R.C.C.S., Reggio Emilia, Italy, 2Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy

    Background/Purpose: : to stress the need of routine use of US imaging in treat to target strategies aiming to achieve remission in early rheumatoid arthritis.…
  • Abstract Number: 1383 • 2014 ACR/ARHP Annual Meeting

    Disease Characteristics and RA Development in Undifferentiated Arthritis: A 2-Year Follow-up Study of 413 Patients with Arthritis of Less Than 16 Weeks Duration

    Gina Hetland Brinkmann1,2, Ellen Sauar Norli1,3, Tore K. Kvien1, Anne Julsrud Haugen2, Lars Grøvle2, Halvor Nygaard4, Cathrine Thunem5, Maria Dahl Mjaavatten1 and Elisabeth Lie1, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Dept. of Rheumatology, Østfold Hospital Trust, Fredrikstad, Norway, 3Dept. of Rheumatology, Martina Hansens Hospital, Bærum, Norway, 4Dept. of Rheumatology, Lillehammer Hospital of Rheumatic Diseases, Lillehammer, Norway, 5Dept. of Medicine, Telemark Hospital, Skien, Norway

    Background/Purpose: Correct identification of the subset of patients with undifferentiated arthritis (UA) who will develop rheumatoid arthritis (RA) is important to enable initiation of appropriate…
  • Abstract Number: 374 • 2014 ACR/ARHP Annual Meeting

    IL-33 and Soluble ST2 Levels As Novel Predictors for Remission and Progression of Carotid Plaque in Early Rheumatoid Arthritis: A Prospective Study

    Jiayun Shen1, Qing Shang1, Ying Ying Leung2, Shui Lian Yu1, Chun-Kwok Wong3, Edmund Li1, Tracy Y. Zhu1 and Lai-Shan Tam1, 1Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, 3Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose Clinical remission is achievable for patients with early rheumatoid arthritis (ERA). Identification of predictors for response of treatment may provide risk estimation and help…
  • Abstract Number: 2689 • 2013 ACR/ARHP Annual Meeting

    Assessing Maintenance Of Remission After Withdrawal Of Etanercept Plus Methotrexate, Methotrexate Alone, Or Placebo In Early Rheumatoid Arthritis Patients Who Achieved Remission With Etanercept and Methotrexate: The Prize Study

    Paul Emery1, Wolfgang Spieler2, Maria Stopinska-Polaszewska3, Nikolay I Korshunov4, Jack Bukowski5, Ronald Pedersen6, Theresa Williams7, Stefanie Gaylord7 and Bonnie Vlahos7, 1Institute Rheumatic and Musculoskeletal Medicine University of Leeds, Leeds, United Kingdom, 2Osteologie und Rheumatologie, ZeFOR GmbH Zentrum für Forschung, Zerbst, Germany, 3Family Physicians Specialists Clinic, Torun, Poland, 4State Budgetary Healthcare Institution of Yaroslavl Region, Yaroslavl, Russia, 5Department of Specialty Care, Pfizer Inc, Collegeville, PA, 6Specialty Care, Pfizer Inc, Collegeville, PA, 7Department of Specialty Care, Pfizer Inc., Collegeville, PA

    Background/Purpose: In the PRIZE study patients (pts) with early (mean 6 mos. since symptom onset) moderate-severe rheumatoid arthritis (RA), who achieved remission after open-label treatment…
  • Abstract Number: 1772 • 2013 ACR/ARHP Annual Meeting

    Better Cost-Effectiveness and Worker Productivity In Triple DMARD Therapy Versus Methotrexate Monotherapy In Early Rheumatoid Arthritis; Cost-Utility Analysis Of The Treach Trial

    P.H.P. de Jong1, A.E.a.M. Weel2, J.J. Luime3, P.J. Barendregt2, A.H. Gerards4, P.A. van der Lubbe4, M.H. de Jager5, P.B. de Sonnaville6, D. van Zeben7, B.A. Grillet8 and J.M.W. Hazes3, 1Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, 2Department of Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 3Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, 4Department of Rheumatology, Vlietland Hospital, Schiedam, Netherlands, 5Department of Rheumatology, Albert Schweitzer Hospital, Dordrecht, Netherlands, 6Department of Rheumatology, Admiraal de Ruyter hospital, Goes, Netherlands, 7Department of Rheumatology, Sint Franciscus Gasthuis, Rotterdam, Netherlands, 8Department of Rheumatology, Zorgsaam Hospital, Terneuzen, Netherlands

    Background/Purpose: In the treatment in the Rotterdam Early Arthritis Cohort (tREACH) trial we showed that treatment goals were attained faster and  maintained with less treatment…
  • Abstract Number: 480 • 2013 ACR/ARHP Annual Meeting

    Levels Of Circulating Mirnas Before and After 12 Months Therapy With Dmards In Patients With Early Rheumatoid Arthritis

    Mária Filková1, Borbala Aradi2, Ladislav Senolt3, Klara Prajzlerova4, Serena Vettori2, Herman F. Mann5, Jiri Vencovsky4, K. Pavelka6, Beat A. Michel7, Renate E Gay2, Steffen Gay2 and Astrid Jüngel2, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 2Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 4Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 5Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 6Department of Clinical and Experimental Rheumatology, Charles University, Prague, Czech Republic, 7Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: The altered expression of cellular miRNAs in the immune and resident cells involved in the pathogenesis of rheumatoid arthritis (RA) has been shown to…
  • Abstract Number: 2646 • 2013 ACR/ARHP Annual Meeting

    Cost-Effectiveness Analysis Of Triple Therapy Versus Etanercept Plus Methotrexate In Early Aggressive Rheumatoid Arthritis: Analysis Based On The TEAR Trial

    Hawre Jalal1, Jeffrey R. Curtis2, Stacey Cofield3, Larry W. Moreland4, James R. O'Dell5 and Kaleb Michaud6, 1Health Polisy and Management, University of Minnesota, Minneapolis, MN, 2Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, AL, 4University of Pittsburgh, Pittsburgh, PA, 5Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 6Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The long-term cost-effectiveness of triple therapy (methotrexate [MTX], sulfasalazine [SSZ], hydroxychloroquine [HCQ]) disease modifying anti-rheumatic drugs (DMARDs) compared to a combination of MTX and…
  • Abstract Number: 1693 • 2013 ACR/ARHP Annual Meeting

    Initial Triple DMARD Therapy Is More Efficient Than Methotrexate Monotherapy In Recent Onset Rheumatoid Arthritis; 1-Year Data Of a Randomized Clinical Trial (tREACH)

    P.H.P. de Jong1, J.M.W. Hazes2, K.H. Han3, A.M. Huisman4, D. van Zeben5, P.A. van der Lubbe6, A.H. Gerards6, B. van Schaeybroeck7, P.B. de Sonnaville8, M.V. Krugten9, J.J. Luime2 and A.E.A.M. Weel3, 1Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, 2Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, 3Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 4Rheumatology, Sint Franciscus Gasthuis, Rotterdam, Netherlands, 5Department of Rheumatology, Sint Franciscus Gasthuis, Rotterdam, Netherlands, 6Department of Rheumatology, Vlietland Hospital, Schiedam, Netherlands, 7Rheumatology, Albert Schweitzer Hospital, Dordrecht, Netherlands, 8Department of Rheumatology, Admiraal de Ruyter hospital, Goes, Netherlands, 9Department of Rheumatology, Admiraal de Ruyter Hospital, Vlissingen, Netherlands

    Background/Purpose: Recommended treatment for DMARD naïve patients is methotrexate (MTX) with or without glucocorticoids (GCs). Triple DMARD therapy however is not recommended, because well proven…
  • Abstract Number: 449 • 2013 ACR/ARHP Annual Meeting

    Work Instability In Early Rheumatoid Arthritis With Elevated Risk Of Employment Loss: Effects Of Adalimumab/Methotrexate Combination Therapy Versus Methotrexate In a Randomized Clinical Trial

    Arthur Kavanaugh1, Josef S. Smolen2, Arijit Ganguli3, Hartmut Kupper3, Mary Cifaldi3, Naijun Chen3 and Dennis Revicki4, 1University of California, San Diego, La Jolla, CA, 2Medical University of Vienna, Vienna, Austria, 3AbbVie Inc., North Chicago, IL, 4United BioSource, Bethesda, MD

    Background/Purpose: Intensive treatment of early rheumatoid arthritis (RA) has been shown to reduce functional disability over time and to positively impact employment outcomes. Adalimumab (ADA)…
  • Abstract Number: 2359 • 2013 ACR/ARHP Annual Meeting

    Impact Of Etanercept-Methotrexate Treatment Withdrawal On Patient-Reported Outcomes In Patients With Early Rheumatoid Arthritis (PRIZE Trial)

    Piotr Wiland1, B Combe2, Oliver FitzGerald3, Hasan Tahir4, Stefanie Gaylord5, Theresa Williams5, Ronald Pedersen6, Jack Bukowski7, Bonnie Vlahos5 and Sameer Kotak8, 1Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland, 2Hôpital Lapeyronie, Montpellier, France, 3Department of Rheumatology, St.Vincent's University Hospital, Dublin, Ireland, 4Barts Health NHS Trust, London, United Kingdom, 5Department of Specialty Care, Pfizer Inc., Collegeville, PA, 6Specialty Care, Pfizer Inc, Collegeville, PA, 7Department of Specialty Care, Pfizer Inc, Collegeville, PA, 8Specialty Care, Pfizer Inc., New York, NY

    Background/Purpose:  Active rheumatoid arthritis (RA) is commonly associated with impairment of physical function and health-related quality of life (QoL), as well as work disability. The…
  • Abstract Number: 1358 • 2013 ACR/ARHP Annual Meeting

    No Differences In Patient-Reported Outcomes By Methotrexate Dose Among Early Rheumatoid Arthritis Patients Treated Concomitantly With Adalimumab: Results From The Concerto Trial

    Roy Fleischmann1, Alan Kivitz2, Ronald F van Vollenhoven3, James W. Shaw4, Stefan Florentinus5, Piyalal M. Karunaratne4, Hartmut Kupper6, Maxime Dougados7 and Gerd Burmester8, 1University of Texas Southwestern Medical Center, Dallas, TX, 2Altoona Center for Clinical Research, Duncansville, PA, 3ClinTRID, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 4AbbVie Inc., North Chicago, IL, 5AbbVie, Rungis, France, 6AbbVie Deutschland GmBH & Co. KG, Ludwigshafen, Germany, 7Hopital Cochin, René Descartes University, Paris, France, 8Department of Rheumatology & Clinical Immunology, Charité-Universitätsmedizin Berlin, Free University and Humboldt University of Berlin, Berlin, Germany

    Background/Purpose: Methotrexate (MTX) in combination with the tumor necrosis factor inhibitor adalimumab (ADA) is an effective therapy for treating rheumatoid arthritis (RA), but the minimum…
  • Abstract Number: 426 • 2013 ACR/ARHP Annual Meeting

    Characteristics of Protocol-Specified Responders/Non-Responders Treated With Etanercept Plus Methotrexate in Period 1 of the Prize Study

    Paul Emery1, Annette Szumski2, Jack Bukowski3, Eustratios Bananis2 and Lisa Marshall4, 1Institute Rheumatic and Musculoskeletal Medicine University of Leeds, Leeds, United Kingdom, 2Specialty Care, Pfizer Inc., Collegeville, PA, 3Department of Specialty Care, Pfizer Inc, Collegeville, PA, 4Pfizer Inc., Collegeville, PA

    Background/Purpose: Although frequently effective, treatment with synthetic or biologic disease-modifying antirheumatic drugs (DMARDs) does not adequately control disease activity in all patients. Prompt identification of…
  • Abstract Number: 2294 • 2013 ACR/ARHP Annual Meeting

    The Role Of Patient Global Disease Activity Score In The Definition Of American College Of Rheumatology/European League Against Rheumatism Remission In Very Early Rheumatoid Arthritis  From The Norwegian Very Early Arthritis Clinic

    Maria Dahl Mjaavatten1, Anne Julsrud Haugen2, Halvor Nygaard3, Olav Bjørneboe4, Patrik Stolt5, Cathrine Thunem6 and Tore Kristian Kvien1,7, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Dept. of Rheumatology, Østfold Hospital Trust, Fredrikstad, Norway, 3Dept. of Rheumatology, Revmatismesykehuset Lillehammer, Lillehammer, Norway, 4Dept. of Rheumatology, Martina Hansens Hospital, Sandvika, Norway, 5Dept. of Rheumatology, Innlandet Hospital Trust, Brumunddal, Norway, 6Dept. of Rheumatology, Betanien Hospital, Skien, Norway, 7Faculty of Medicine, University of Oslo, Oslo, Norway

    Background/Purpose: In the ACR/EULAR criteria remission can be defined in two ways, either by fulfilment of 4 Boolean criteria or by a Simplified Disease Activity…
  • Abstract Number: 1361 • 2013 ACR/ARHP Annual Meeting

    Stringent Therapies Improve Clinical, Radiographic and Magnetic Resonance Imaging Outcome In Early-Stage Rheumatoid Arthritis Patients From Japanese Population: Longitudinal Study From Nagasaki Early Arthritis Cohort

    Mami Tamai1,2, Yoshikazu Nakashima3, Junko Kita4, Ayuko Takatani4, Ayako Nishino3, Takahisa Suzuki3, Yoshiro Horai3, Akitomo Okada5, Shin-ya Kawashiri3,6, Naoki Iwamoto3, Kunihiro Ichinose3, Kazuhiko Arima6, Hideki Nakamura3, Tomoki Origuchi7, Masataka Uetani8, Katsumi Eguchi9 and Atsushi Kawakami3, 1Center for Health & Community Medicine, Nagasaki University, Nagasaki, Japan, 2Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 4Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan, 6Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 7Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 8Department of Radiology and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 9Sasebo City General Hospital, Sasebo, Nagasaki, Japan

    Background/Purpose: Prognosis of the patients with rheumatoid arthritis (RA) nowadays is supposed to become better by treat-to-target (T2T) strategy. Osteitis determined by magnetic resonance imaging…
  • Abstract Number: 416 • 2013 ACR/ARHP Annual Meeting

    Changes In Body Composition On Two Different Glucocorticoid Regimens In Early RA: Experience From The Cobra-Light Trial

    Nicole P.C. Konijn1, Karin Britsemmer2, Marieke M. ter Wee1, Debby den Uyl1, Birgit S. Blomjous1, Maarten Boers3,4, Dirkjan van Schaardenburg5,6, Willem F. Lems1,6 and Michael T Nurmohamed5,7, 1Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 2Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 3Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands, 4Deapartment of Epidemiology and Biostatistics, Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands, 5VU University Medical Center, Amsterdam, Netherlands, 6Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands, 7Rheumatology, Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands

    Background/Purpose: Prednisolone improves joint inflammation and disease severity in rheumatoid arthritis (RA), but is associated with multiple cardiovascular, metabolic and endocrine side effects and may…
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