Abstracts tagged "Early Rheumatoid Arthritis"

Abstract Number: 1484 • 2016 ACR/ARHP Annual Meeting
Exploring the Link Between RA Disease Activity, Lipid Levels, and Cardiovascular Disease in an Early Inflammatory Arthritis Cohort
Saurash Reddy, Xiaobo Meng and Carol Hitchon, University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Rheumatoid arthritis (RA) has been established as a risk factor for cardiovascular disease (CVD), with systemic inflammation being linked with atherosclerosis. Traditional CVD risk…
Abstract Number: 3210 • 2016 ACR/ARHP Annual Meeting
10+ Years’ Follow-up of a Danish 2-Year Treat-to-Target RCT in Patients with Early Rheumatoid Arthritis: Baseline Predictors of Functional and Radiographic Outcomes
Merete Lund Hetland¹, Kristian Stengaard-Pedersen², Peter Junker¹, Hanne Lindegaard¹, Torkell Ellingsen¹, Jan Pødenphant², Henrik Skjødt¹, Aage Vestergaard², Bo Jannik Ejbjerg¹, Søren Jacobsen¹, Niels Steen Krogh¹, Mikkel Ostergaard¹ and Kim Hørslev-Petersen², ¹Rigshospitalet (Glostrup and Blegdamsvej), Århus University Hospital, Odense University Hospital, Herlev/Gentofte Hospital, Slagelse Sygehus, Chr X hospital (University of South Denmark) and Zitelab Aps, DANBIO Registry and Departments of Rheumatology, Glostrup, Denmark, ²Rigshospitalet (Glostrup and Blegdamsvej), Århus University Hospital, Odense University Hospital, Herlev/Gentofte Hospital, Slagelse Sygehus, Chr X hospital (University of South Denmark) and Zitelab Aps, DANBIO Registry and Departments of Rheumatology, Copenhagen, Denmark
Background/Purpose: Few RCTs have investigated long-term (10+ years) outcomes of goal-directed synovitis suppression in early rheumatoid arthritis (RA). The CIMESTRA trial was a 2-year double-blinded…
Abstract Number: 487 • 2015 ACR/ARHP Annual Meeting
Early Rheumatoid Arthritis Patients in the Worse Disease Trajectory Group Fail to Achieve Improvement in Physical Function
Cheryl Barnabe¹, Ye Sun², Susan J. Bartlett^3,4, Gilles Boire⁵, Carol Hitchon⁶, Edward C. Keystone⁷, Boulos Haraoui⁸, J Carter Thorne², Diane Tin⁹, Janet E. Pope¹⁰, VP Bykerk¹¹ and CATCH Investigators, ¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, ⁴Medicine , Divisions of Clinical Epidemiology, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, ⁵Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Department of Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁷Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁸Institut de Rhumatologie, Montreal, QC, Canada, ⁹The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹⁰University of Western Ontario, London, ON, Canada, ¹¹Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Disease trajectories in early rheumatoid arthritis (ERA) are characterized by differences in absolute levels of disease activity and rates of improvement, with patients in…
Abstract Number: 968 • 2015 ACR/ARHP Annual Meeting
Certolizumab Pegol in Combination with Methotrexate in DMARD-Naïve Patients with Active, Severe, Progressive Rheumatoid Arthritis: Results from a Randomized, Double-Blind, Controlled Phase 3 Study
Michael Weinblatt¹, Clifton Bingham², Gerd Burmester³, VP Bykerk⁴, Daniel E. Furst⁵, Xavier Mariette⁶, Désirée van der Heijde⁷, Daljit Tatla⁸, Catherine Arendt⁹, Irina Mountian¹⁰, Brenda VanLunen¹¹ and Paul Emery¹², ¹Rheumatology Immunology & Allergy, Brigham and Women's Hospital, Boston, MA, ²Johns Hopkins University, Baltimore, MD, ³Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁶Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ⁷University Hospital, Maastricht, Netherlands, ⁸8010 Arco Corporate Dr, UCB Pharma, Raleigh, NC, ⁹Global Medical Affairs, UCB Pharma, Brussels, Belgium, ¹⁰UCB Pharma, Brussels, Belgium, ¹¹UCB Pharma, Raleigh, NC, ¹²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: Early stages of rheumatoid arthritis (RA) may provide a therapeutic window in which biologic agents are most effective.1 C-EARLY (NCT01519791) is a phase 3…
Abstract Number: 2689 • 2015 ACR/ARHP Annual Meeting
Discrepancies Between Patients and Physicians in Their Perceptions of Rheumatoid Arthritis Disease Activity Are Multifactorial in Early Rheumatoid Arthritis
Cécile Gaujoux-Viala¹, Nathalie Rincheval², Laure Gossec³, Francis Guillemin⁴, Maxime Dougados⁵, Jean-Pierre Daures⁶ and BG Combe⁷, ¹Nîmes University Hospital, Rheumatology Department; EA 2415, Montpellier University, Nîmes, France, ²Biostatistic, EA 2415, Epidemiology unit, Montpellier, France, ³Rheumatology, Pitié Salpetriere Hospital, Paris, France, ⁴University of Lorraine, Nancy, France, ⁵Paris Descartes University, Rheumatology Department, Cochin Hospital, AP-HP. INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France, ⁶Biostatistic, EA 2415 Epidemiology unit, Montpellier, France, ⁷Lapeyronie, Montpellier, France
Background/Purpose: Patients and physicians often differ in their perceptions of rheumatoid arthritis (RA) disease activity, as quantified by the patient's global assessment (PGA) and by…
Abstract Number: 489 • 2015 ACR/ARHP Annual Meeting
Drug Survival and Toxicity of Methotrexate Monotherapy in Daily Clinical Practice. Results from an Early Arthritis Clinic
Christian A. Waimann^1,2, Margarita Landi³, Fernando Dal Pra³, Gustavo Citera⁴, Maria Celeste Orozco⁴, Osvaldo Luis Cerda³, Federico Ceccatto⁵, Sergio Paira⁵, Francisco Colombres⁶, Alberto Berman⁷, Horacio Berman⁷, Anastasia Secco⁸, Marta Mamani⁸, Maritza Manzano⁸, Maria Victoria Martire⁸, Francisco Caeiro⁹, Maria Haye Salinas¹⁰, Alejandro J. Alvarellos¹⁰, Ana C. Alvarez¹⁰, Javier Rosa¹¹, Valeria Scaglioni¹², Enrique R. Soriano¹¹, Josefina Marcos¹³, Mercedes Argentina García¹⁴, AC Costi¹⁵, Alejandro Martinez¹⁶, Oscar Luis Rillo¹⁶, Edson Veloso¹⁷, Ricardo V. Juárez¹⁸, Maria Elena Crespo¹⁹, Ana Quinteros²⁰, Doralia Vasquez²⁰, C Ledesma²¹, Gabriela Salvatierra²¹, R Quintana²², Monica Sacnun²³ and Marcelo Abdala²⁴, ¹Rheumatology, Hospital Dr. Hector Cura, Olavarria, Argentina, ²Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁴Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁵Hospital Jose Maria Cullen, Santa Fe, Argentina, ⁶Tucuman, Centro Médico Privado de Reumatología, Tucumán, Argentina, ⁷Centro Médico Privado de Reumatología, Tucumán, Argentina, ⁸Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁹Reumatología, Hospital Privado de Córdoba, Córdoba, Argentina, ¹⁰Rheumatology, Hospital Privado de Córdoba, Córdoba, Argentina, ¹¹Hospital Italiano, Buenos Aires, Argentina, ¹²Rheumatology, Hospital Italiano, Buenos Aires, Argentina, ¹³HIGA San Martín, La Plata, Argentina, ¹⁴Rheumatology Unit, HIGA San Martín, La Plata, Argentina, ¹⁵Rheumatology, HIGA San Martín, La Plata, Argentina, ¹⁶Rheumatology, Hospital General de Agudos “Dr. Ignacio Pirovano”, Buenos Aires, Argentina, ¹⁷Sanatorio y Universidad Adventista Del Plata, Entre Rios, Argentina, ¹⁸Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, ¹⁹Hospital Señor del Milagro, Salta, Argentina, ²⁰Centro Integral De Reumatologia, Tucumán, Argentina, ²¹Instituto Provincial De Rehabilitación Integral, Santiago del Estero, Argentina, ²²Rheumatology, Hosp. Provincial, Rosario, Argentina, ²³Hosp. Provincial, Rosario, Argentina, ²⁴Hospital Provincial del Centenario, Santa Fe, Argentina
Background/Purpose: Several trials had reported the efficacy and toxicity of methotrexate monotherapy in patients with early rheumatoid arthritis. However, patients outside clinical trials could be…
Abstract Number: 1205 • 2015 ACR/ARHP Annual Meeting
The Spectrum of Early RA Practice Across the Globe: Results from a Multinational Cross Sectional Survey
Elena Nikiphorou¹, James Galloway^2,3, Piet L van Riel⁴, Andrew Östör⁵, Glenn Haugeberg^6,7, Feride Gogus^8,9, Markku Kauppi¹⁰, Yusuf Yazici¹¹ and Tuulikki Sokka-Isler¹², ¹Jyvaskyla Central Hospital, Jyvaskyla, Finland, ²Academic Department of Rheumatology, King´s College London, London, United Kingdom, ³King's College Hospital, Department of Rheumatology, London, London, United Kingdom, ⁴Scientific Institute for Quality of Healthcare, Radboud University Medical Center, Nijmegen, Netherlands, ⁵Addenbrooke's Hospital, Cambridge, United Kingdom, ⁶Rheumatology, The Norwegian University of Science and Technology, Trondheim, Norway, ⁷Head of the Department of Rheumatology, Martina Hansens Hospital, Bærum, Norway, ⁸University of Gazi, Ankara, Turkey, ⁹Gazi University, Faculty of Medicine, Ankara, Turkey, ¹⁰Rheumatology, Päijät-Häme Central Hospital, Lahti, Finland, ¹¹Rheumatology, Hospital for Joint Diseases and Medicine, NYU Langone Medical Centre, New York, NY, ¹²Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland
Background/Purpose: Early diagnosis & treatment are crucial to the management of rheumatoid arthritis (RA). Despite this, the approach to early RA management appears to be…
Abstract Number: 2695 • 2015 ACR/ARHP Annual Meeting
Th17 Cell Related Cytokines and Microarray Expression Profiles in Patients with Early Rheumatoid Arthritis
Youngkyun Kim¹, Kijun Lee², Hae-Rim Kim³, Sang Heon Lee⁴, Ji Hyeon Ju⁵ and HO-YOUN KIM⁶, ¹1Convergent Research Consortium for Immunologic Disease, The Catholic University of Korea, Seoul, South Korea, ²The Catholic University of Korea, Seoul, South Korea, ³Konkuk University Medical Center, Seoul, South Korea, ⁴Konkuk University Hospital, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁶Konkuk university hospital, Seoul, South Korea
Background/Purpose: The purpose of this study is to explore new biomarkers for early diagnosis of rheumatoid arthritis (RA). For better discrimination power, we especially investigated…
Abstract Number: 503 • 2015 ACR/ARHP Annual Meeting
Predictors for Attaining Remission at Two Consecutive Visits in Newly Diagnosed Early RA Patients
T. Martijn Kuijper¹, J.J. Luime², P.H.P. de Jong³, A. H. Gerards⁴, Derkjen van Zeben⁵, I. Tchetverikov⁶, P.B.J. de Sonnaville⁷, M. van Krugten⁸, B. Grillet⁹, Mieke Hazes¹⁰ and A.E.A.M. Weel^11,12, ¹Rheumatology, Erasmus MC, Rotterdam, Netherlands, ²Department of Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, ³Department of Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Vlietland Hospital, Schiedam, Netherlands, ⁵Rheumatology, Sint Franciscus Gasthuis, Rotterdam, Netherlands, ⁶Albert Schweitzer Ziekenhuis, Dordrecht, Netherlands, ⁷Oosterschelde Hospital, Goes, Netherlands, ⁸Rheumatology, Admiraal de Ruyter Hospital, Vlissingen, Netherlands, ⁹Rheumatology, ZorgSaam Hospital, Terneuzen, Netherlands, ¹⁰Rheumatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ¹¹Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ¹²Department of Rheumatology, Maasstad Hospital, Rotterdam, Netherlands
Background/Purpose: Early and intensive treatment with DMARDs are essential for remission induction in newly diagnosed RA patients. However, demographic, psychosocial and disease related factors may…
Abstract Number: 1325 • 2015 ACR/ARHP Annual Meeting
Age Effects Joint Space Narrowing in Early Active Rheumatoid Arthritis Patients
Xanthe M.E. Matthijssen¹, Gülsah Akdemir¹, Iris M. Markusse², Yvonne P. Goekoop-Ruiterman³, K. Huub Han⁴, Annekoos L. Huidekoper⁵, Pit J.S.M. Kerstens⁶, Willem F. Lems⁷, T. W. J. Huizinga¹ and Cornelia F. Allaart¹, ¹Rheumatology, LUMC, Leiden, Netherlands, ²LUMC, Leiden, Netherlands, ³Rheumatology, HAGA hospital, The Hague, Netherlands, ⁴Rheumatology, Maasstad hospital, Rotterdam, Netherlands, ⁵Rheumatology, Bronovo hospital, The Hague, Netherlands, ⁶Department of Rheumatology, Reade, Amsterdam, Netherlands, ⁷Rheumatology, Amsterdam Rheumatology and immunology Center, VU University medical center, Amsterdam, Netherlands
Background/Purpose: Joint space narrowing (JSN) and erosions are the major radiologic markers of radiographic progression in rheumatoid arthritis (RA), as scored by the Sharp/van der…
Abstract Number: 2721 • 2015 ACR/ARHP Annual Meeting
Elevated Subgingival Levels of Periodontal Pathogens in Rheumatoid Arthritis Patients, Particularly Leptotrichia species in New-Onset Disease
Sheila Arvikar¹, Hatice Hasturk², Daniel Nguyen², Klemen Strle³, Marcy B. Bolster⁴, Deborah Collier⁵, Allen C. Steere⁶ and Alpdogan Kantarci², ¹Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Applied Oral Health Sciences, Forsyth, Cambridge, MA, ³Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Periodontitis, a polymicrobial infectious and inflammatory disease of tooth-supporting structures, shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. Most studies…
Abstract Number: 514 • 2015 ACR/ARHP Annual Meeting
MRI Bone Oedema at Enrollment Predicts the Development of Rapid Radiographic Progression at 1 Year Toward Patients with Early-Stage Rheumatoid Arthritis: Results from Nagasaki University Early Arthritis Cohort
Yoshikazu Nakashima¹, Mami Tamai², Toru Michitsuji³, Toshimasa Shimizu², Shoichi Fukui⁴, Masataka Umeda¹, Ayako Nishino¹, Tomohiro Koga³, Shin-ya Kawashiri⁵, Naoki Iwamoto², Kunihiro Ichinose², Yasuko Hirai⁴, Hideki Nakamura⁴, Tomoki Origuchi⁶ and Atsushi Kawakami⁴, ¹Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ⁴Nagasaki University, Nagasaki, Japan, ⁵Kyushu multicenter rheumatoid arthritis ultrasound prospective observational cohort study group, Nagasaki, Japan, ⁶Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan
Background/Purpose: To clarify whether MRI bone oedema predicts the development of rapid radiographic progression (RRP) in Nagasaki University Early Arthritis Cohort patients with early-stage rheumatoid…
Abstract Number: 1636 • 2015 ACR/ARHP Annual Meeting
Clinical Benefit of 1-Year Certolizumab Pegol Treatment in MTX-Naïve, Early Rheumatoid Arthritis Patients Is Maintained after Discontinuation up to 1 Year
Tatsuya Atsumi¹, Kazuhiko Yamamoto², Tsutomu Takeuchi³, Hisashi Yamanaka⁴, Naoki Ishiguro⁵, Yoshiya Tanaka⁶, Katsumi Eguchi⁷, Akira Watanabe⁸, Hideki Origasa⁹, Toshiharu Shoji¹⁰, Osamu Togo¹¹, Toshiyuki Okada¹², Désirée van der Heijde¹³, Nobuyuki Miyasaka¹⁴ and Takao Koike¹⁵, ¹Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ³Keio University School of Medicine, Tokyo, Japan, ⁴Tokyo Women's Medical University, Tokyo, Japan, ⁵Department of Orthopedic Suregery, Nagoya University Hospital, Nagoya, Japan, ⁶The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ⁷Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁸Tohoku University, Sendai, Japan, ⁹Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama, Toyama, Japan, ¹⁰Department of Clinical Research and Development, Otsuka Pharmaceutical Co., Ltd, Shinagawa-ku, Tokyo, Japan, ¹¹Biometrics Group, UCB Pharma, Tokyo, Japan, ¹²Astellas Pharma Inc., Japan, Tokyo, Japan, ¹³University Hospital, Maastricht, Netherlands, ¹⁴Tokyo Medical and Dental University, Tokyo, Japan, ¹⁵Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Background/Purpose: Efficacy and safety of certolizumab pegol (CZP) treatment in combination with optimized-dose MTX in Japanese MTX-naïve early rheumatoid arthritis (RA) patients (pts) with poor…
Abstract Number: 2736 • 2015 ACR/ARHP Annual Meeting
Reduction of Disease Burden on Workplace and Household Productivity Following 52 Weeks of Treatment with Certolizumab Pegol in Combination with Methotrexate in DMARD-Naïve Patients with Active, Severe, Progressive Rheumatoid Arthritis
VP Bykerk¹, Clifton Bingham², Gerd Burmester³, Daniel E. Furst⁴, Xavier Mariette⁵, Oana Purcaru⁶, Brenda VanLunen⁷, Michael Weinblatt⁸ and Paul Emery⁹, ¹Hospital for Special Surgery, New York, NY, ²Johns Hopkins University, Baltimore, MD, ³Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ⁶Outcomes & Access Immunology, UCB, Brussels, Belgium, ⁷UCB Pharma, Raleigh, NC, ⁸Rheumatology Immunology & Allergy, Brigham and Women's Hospital, Boston, MA, ⁹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is associated with work disability and lower employment rates (evidence shows 20–30% of pts are work disabled in the first 3…
Abstract Number: 519 • 2015 ACR/ARHP Annual Meeting
In Indigenous North Americans at High Risk for RA Complement C5 Level Is Associated with ACPA Positivity and C5a with Transition to Synovitis Even after Correcting for in Vitro Complement Activation Found with Prolonged Sample Storage
Ceri Richards¹, Carol Hitchon², Xiaobo Meng³, Irene Smolik⁴, David Robinson⁴ and Hani S. El-Gabalawy⁴, ¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, ²Department of Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ³University of Manitoba, Winnipeg, MB, Canada, ⁴Arthritis Center, University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Complement activation, a key component of innate immunity and activator of adaptive immunity has been linked to RA pathogenesis. Anti-citrullinated peptide antibody (ACPA) and…

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