Abstracts tagged "Early Rheumatoid Arthritis and glucocorticoids"

Abstract Number: 389 • ACR/ARHP Annual Meeting 2014
High 11B-HSD1 Activity Is Associated with Progression to Rheumatoid Arthritis in Patients with a New Onset of Inflammatory Arthritis
Dominika Nanus¹, Andrew Filer², Lorraine Yeo¹, Dagmar Scheel-Toellner³, Rowan Hardy⁴, Gareth Lavery⁵, Paul Stewart⁶, Christopher Buckley⁷, Mark Cooper⁸ and Karim Raza¹, ¹Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, ²Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ³Rheumatology Research Group, Centre for Translational Inflammation Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK, Birmingham, United Kingdom, ⁴Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, United Kingdom, ⁵Centre for Endocrinology, Diabetes and Metabolism,, University of Birmingham, Birmingham, United Kingdom, ⁶University of Leeds, Leeds, United Kingdom, ⁷Rheumathology Research Group, University of Birmingham, Birmingham, United Kingdom, ⁸University of Sydney, ANZAC Research Institute, Sydney, Australia
Background/Purpose Inadequate endogenous glucocorticoid (GC) synthesis during inflammation has been proposed as an aetiological factor in the development of rheumatoid arthritis (RA). It has been…