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Abstracts tagged "drug treatment and clinical trials"

  • Abstract Number: 2520 • ACR/ARP Annual Meeting 2019

    Treatment of SLE Patients with the Immunoproteasome Inhibitor KZR-616: Results from the First 3 Cohorts of an Open-Label Phase 1b Dose Escalation Trial

    Richard Furie1, Darrin Bomba 2, Maria Dall'Era 3, Amber Khan 4, Miguel Soneira 4, Janet Anderl 2, Jinhai Wang 2, Christopher Kirk 2 and Niti Goel 5, 1Northwell Health, Great Neck, NY, 2Kezar Life Sciences, SOUTH SAN FRANCISCO, CA, 3University of California, San Francisco, San Francisco, CA, 4Accurate Clinical Research, Houston, TX, 5Kezar Life Sciences, Duke University School of Medicine, South San Francisco, CA

    Background/Purpose: Nonspecific proteasome inhibitors, eg, bortezomib (BTZ), target both the constitutive and immuno- proteasome and are approved for the treatment of multiple myeloma. While BTZ…
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