Abstracts tagged "drug safety"

Abstract Number: 961 • 2018 ACR/ARHP Annual Meeting
The Association of Biologic Drug-Levels with Infection Risk: Results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis
Meghna Jani¹, William G Dixon¹, Mark Lunt¹, Diederik De Cock¹, John Isaacs², Ann Morgan³, Kath Watson¹, Anthony G. Wilson⁴, Anne Barton^5,6 and Kimme L. Hyrich^1,5, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ²Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, Great Britain, ⁴UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, ⁵National Institute of Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁶Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University Of Manchester, Manchester, United Kingdom
Background/Purpose: High dose tumour necrosis factor inhibitor (TNFi) drugs are associated with an increased serious infection (SI) risk[1]. It is feasible that high biologic…
Abstract Number: 1398 • 2018 ACR/ARHP Annual Meeting
Inflammatory Arthritis DMARD Adverse Effects Are Pervasive and Can Greatly Impact Quality of Life and Work and Social Roles: Initial Results from the Omeract Safety Working Group
Kathleen M. Andersen¹, Ayano Kelly², Anne Lyddiatt³, Clifton O. Bingham III⁴, Vivian P. Bykerk⁵, Marita Cross⁶, Adena Batterman⁷, Joan Westreich⁸, Lyn March⁹, Michelle Jones¹⁰, Beverly Shea¹¹, Peter Tugwell¹², Peter Brooks¹³, Lee S. Simon¹⁴, Robin Christensen¹⁵ and Susan J. Bartlett¹⁶, ¹Department of Family Medicine, McGill University, Montreal, QC, Canada, ²Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia, ³Musculoskeletal Group, Cochrane Collaboration, Hamilton, ON, Canada, ⁴Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Deptartment of Rheumatology, Hospital for Special Surgery, New York, NY, ⁶Institute of Bone and Joint Research–Kolling Institute, University of Sydney, Sydney, Australia, ⁷Social Work Programs, Hospital for Special Surgery, New York, NY, ⁸Department of Social Work Programs, Hospital for Special Surgery, New York, NY, ⁹Department of Rheumatology, Northern Clinical School, Institute of Bone and Joint Research, Kolling Institute, University of Sydney & Department of Rheumatology, Royal North Shore Hospital, St Leonards, Sydney, Australia, ¹⁰Johns Hopkins University School of Medicine, Baltimore, MD, ¹¹University of Ottawa, Ottawa, ON, Canada, ¹²Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada, ¹³The University of Melbourne, Victoria, Australia, ¹⁴SDG LLC Consulting, West Newton, MA, ¹⁵Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, ¹⁶Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada
Background/Purpose: There is suboptimal reporting of adverse events (AE) in trials. The OMERACT Safety Working Group is developing a patient-centered AE collection and reporting approach…
Abstract Number: 1542 • 2018 ACR/ARHP Annual Meeting
Real-World Data from a Post-Approval Safety Surveillance Study of Tofacitinib Vs Biologic Dmards and Conventional Synthetic Dmards: Five-Year Results from a US-Based Rheumatoid Arthritis Registry
Joel Kremer¹, Laura C. Cappelli², Carol J. Etzel³, Jeffrey Greenberg³, Jamie Geier⁴, Ann Madsen⁴, Connie Chen⁴, Alina Onofrei³, Christine J Barr³, Dimitrios A. Pappas³, Kimberly J Dandreo³, Andrea Shapiro⁵, Carol A Connell⁶ and Arthur Kavanaugh⁷, ¹Albany Medical College and the Center for Rheumatology, Albany, NY, ²Johns Hopkins University, Baltimore, MD, ³Corrona LLC, Waltham, MA, ⁴Pfizer Inc, New York, NY, ⁵Pfizer Inc, Peapack, NJ, ⁶Pfizer Inc, Groton, CT, ⁷University of California, San Diego School of Medicine, La Jolla, San Diego, CA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. A prospective observational 5-year study, embedded within the US Corrona RA registry,…
Abstract Number: 1853 • 2018 ACR/ARHP Annual Meeting
Paternal Use of Methotrexate (MTX) and Congenital Malformations – a Systematic Review and Meta-Analysis
Thomas Bo Jensen¹, Mikkel Bring Christensen^1,2 and Jon Trærup Andersen^1,2, ¹Department of Clinical Pharmacology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, ²Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Background/Purpose: In rheumatology, fertile men and women are commonly treated with methotrexate (MTX). Maternal preconceptional MTX exposure is teratogenic, but less is known about paternal…
Abstract Number: 2253 • 2018 ACR/ARHP Annual Meeting
Cardiovascular Disease, Other Purported Risk Factors, and Allopurinol-Associated Severe Cutaneous Adverse Reactions: A General Population-Based Cohort Study
Na Lu¹, Chio Yokose², Hui Xie^1,3, Gloria Li¹, Sharan K. Rai^4,5, Seoyoung C. Kim⁶ and Hyon K. Choi², ¹Arthritis Research Canada, Richmond, BC, Canada, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ³Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada, ⁴Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ⁵Graduate School of Arts and Sciences, Harvard University, Cambridge, MA, ⁶Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: A recent US Medicaid study found that in addition to certain races (Asians and Blacks), older age, female sex, chronic kidney disease (CKD), and…
Abstract Number: 2391 • 2018 ACR/ARHP Annual Meeting
Methotrexate Polyglutamates As an Evaluation Tool for Appropriate Dosage of Oral Methotrexate Administration in Pediatric Patients
Nami Okamoto¹, Kosuke Shabana², Yasuo Nakagishi³, Kenichi Nishimura⁴, Mao Mizuta⁵, Yuka Okura⁶, Masaki Shimizu⁵, Hiroyuki Wakiguchi⁷, Junko Yasumura⁸ and Masaaki Mori⁹, ¹Pediatrics, Osaka Medical College, Takatsuki, Japan, ²Department of Pediatrics, Osaka Medical College, Takatsuki, Japan, ³Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan, ⁴Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁵Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, ⁶Department of Pediatrics, KKR Sapporo Medical Center, Sapporo, Japan, ⁷Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Japan, ⁸Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan, ⁹Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: Since MTX metabolism varies depending on age and dosage, we need to know optimal MTX administration method in children. We performed multi-center prospective study…
Abstract Number: 2834 • 2018 ACR/ARHP Annual Meeting
The Presence of Anti-Rituximab Antibodies Predicts Infusion-Related Reactions in Patients with Systemic Lupus Erythematosus
Chris Wincup¹, Madhvi Menon¹, Edward Smith², David A. Isenberg¹, Elizabeth Jury³ and Claudia Mauri⁴, ¹University College London, London, United Kingdom, ²Centre for Rheumatology Research, University College London, London, United Kingdom, ³Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom, ⁴Division of Medicine, Centre for Rheumatology Research, University College London, University College London, London, United Kingdom
Background/Purpose: Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody that is commonly used in the treatment of severe and refractory SLE. Although generally well…
Abstract Number: 215 • 2017 ACR/ARHP Annual Meeting
Clinical Pharmacist As Part of the Interprofessional Team Improves Quality of Care in Patients with Rheumatic Disease
Jessica Farrell¹, Lee S. Shapiro¹ and Mitchell Miller², ¹The Center for Rheumatology, Albany, NY, ²Albany College of Pharmacy and Health Sciences, Albany, NY
Background/Purpose: Successful multidisciplinary models exist for the management of chronic diseases such as diabetes, cardiovascular disease, infectious diseases, kidney disease and psychiatric illnesses. A multidisciplinary…
Abstract Number: 841 • 2017 ACR/ARHP Annual Meeting
Optimal Regimens of Sulfamethoxazole-Trimethoprim for Chemoprophylaxis of Pneumocystis Pneumonia in Patients with Systemic Rheumatic Diseases: 52-Week Follow-up of a Non-Blinded, Randomized Controlled Trial
Masayoshi Harigai^1,2, Masako Utsunomiya^2,3,4, Hiroaki Dobashi⁵, Toshio Odani^6,7, Kazuyoshi Saito^8,9, Naoto Yokogawa¹⁰, Kenji Nagasaka^11,12, Kenchi Takenaka^3,11, Makoto Soejima^11,13, Takahiko Sugihara¹⁴, Hiroyuki Hagiyama¹⁵, Shinya Hirata¹⁶, Kazuo Matsui^17,18, Yoshinori Nonomura¹⁹, Masahiro Kondo²⁰, Fumihito Suzuki^13,21, Makoto Tomita²², Mari Kihara²³, Waka Yokoyama³, Fumio Hirano²⁴, Hayato Yamazaki³, Ryoko Sakai^2,25, Toshihiro Nanki^2,26, Ryuji Koike^2,3, Hitoshi Kohsaka³ and Nobuyuki Miyasaka³, ¹Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ³Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Department of Rheumatology, Musashino Red Cross Hospital, Tokyo, Japan, ⁵Internal Medicine Division of Hematology, Rheumatology, and Respiratory Medicine, Kagawa University, Kagawa, Japan, ⁶Third Department of Internal Medicine, Obihiro-Kosei General Hospital, Hokkaido, Japan, ⁷Molecular Physiology and Therapeutics Branch/Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research (NIDCR)/ National Institutes of Health (NIH), Bethesda, MD, ⁸Tobata General Hospital, Fukuoka, Japan, ⁹The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ¹⁰Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ¹¹Department of Rheumatology, Ome Municipal General Hospital, Tokyo, Japan, ¹²Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences,, Tokyo Medical and Dental University, Tokyo, Japan, ¹³Department of Rheumatology, Soka Municipal Hospital, Saitama, Japan, ¹⁴Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, ¹⁵Department of Rheumatology, Yokohama City Minato Red Cross Hospital, Kanagawa, Japan, ¹⁶Department of Hematology, Rheumatology, and Infectious Disease, Kumamoto University, Kumamoto, Japan, ¹⁷Department of Rheumatology, Kameda Medical Center, Chiba, Japan, ¹⁸Department of Internal Medicine, Takikawa Municipal Hospital, Hokkaido, Japan, ¹⁹Department of Rheumatology, Tokyo Kyosai Hospital, Tokyo, Japan, ²⁰Department of Rheumatology, Faculty of Medicine, Shimane University, Shimane, Japan, ²¹Department of Rheumatology, JA Toride Medical Center, Ibaraki, Japan, ²²Clinical Research Center, Tokyo Medical and Dental University, Tokyo, Japan, ²³Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ²⁴Departments of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²⁵Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, ²⁶Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
Background/Purpose: Sulfamethoxazole-trimethoprim (SMX/TMP) is a standard drug for the prophylaxis of Pneumocystis pneumonia (PCP), but is sometimes discontinued due to adverse events (AEs). We have…
Abstract Number: 1036 • 2017 ACR/ARHP Annual Meeting
Blood Glucose Changes Surrounding Initiation of Tumor-Necrosis Factor Inhibitors and Conventional Disease-Modifying Anti-Rheumatic Drugs in Veterans with Rheumatoid Arthritis
Patrick R. Wood¹, Evan Manning², Joshua Baker³, Grant Cannon⁴, Lisa Davis⁵, Bryant R. England⁶, Ted R. Mikuls⁷ and Liron Caplan⁸, ¹Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO, ³Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁴Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ⁵Div of Rheumatology, Denver Health, Denver, CO, ⁶Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁷Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁸Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: There is evidence linking activation of the innate immune system and insulin resistance. Perturbations in glucose homeostasis upon initiation of tumor-necrosis factor inhibitors (TNFis)…
Abstract Number: 1316 • 2017 ACR/ARHP Annual Meeting
Risk of Preterm Delivery Associated with Perinatal Exposure to Dmards in Women with Inflammatory Arthritis: A Population-Based Cohort Study
Nicole W. Tsao^1,2, Eric C. Sayre², Mohsen Sadatsafavi¹, J. Antonio Avina-Zubieta^2,3, Stephanie Ensworth⁴ and Mary A. De Vera^1,2, ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Given the limited data on impacts of perinatal medication use, our objective was to investigate the association between conventional synthetic DMARD (csDMARD) use preconception…
Abstract Number: 2222 • 2017 ACR/ARHP Annual Meeting
Comparative Risk of Respiratory Depression in Patients Treated with Opioids for Non-Malignant Pain
Meghna Jani, Kamilla Kopec-Harding, Mark Lunt and William G Dixon, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Opioid use for non-cancer pain has increased considerably over the last 30 years. The U.S. Food and Drug Administration announced several boxed warnings in…
Abstract Number: 2472 • 2017 ACR/ARHP Annual Meeting
Integrated Phase 3 Safety Results of Sirukumab, an Anti–IL-6 Cytokine Monoclonal Antibody, in Patients with Active Rheumatoid Arthritis
Daniel Aletaha¹, Carter Thorne², Michael Schiff³, Masayoshi Harigai⁴, Prasheen Agarwal⁵, Ravi Rao⁶, Christopher Cohen⁷, Ben Cheng⁵, Kurt Brown⁷ and Benjamin Hsu⁵, ¹Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²University of Toronto, Newmarket, ON, Canada, ³University of Colorado School of Medicine, Aurora, CO, ⁴Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁵Janssen Research & Development, LLC, Spring House, PA, ⁶GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom, ⁷GlaxoSmithKline, Collegeville, PA
Background/Purpose: Sirukumab (SIR), a human monoclonal antibody that selectively binds to the IL-6 cytokine with high affinity, is in development for rheumatoid arthritis (RA) in…
Abstract Number: 1057 • 2016 ACR/ARHP Annual Meeting
Effect of Quantitative Information Concerning Medication Side-Effects on Risk Perception
Susan J. Blalock¹ and Matthew Dixon², ¹Eshelman School of Pharmacy, UNC at Chapel Hill, Chapel Hill, NC, ²Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, Namibia
Background/Purpose: The Food and Drug Administration (FDA) requires that patients prescribed a bisphosphonate to treat osteoporosis receive an FDA-approved Medication Guide that warns of the…
Abstract Number: 2162 • 2016 ACR/ARHP Annual Meeting
Frequent Discussion of Insomnia and Weight Gain with Glucocorticoid Therapy: An Analysis of Twitter Posts
Rikesh Patel¹, Nabarun Dasgupta², Maksim Belousov³, Meghna Jani⁴, Carly Winokur², Goran Nenadic³ and William G Dixon^1,5, ¹Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom, ²Epidemico Inc., Boston, MA, ³School of Computer Sciences, The University of Manchester, Manchester, United Kingdom, ⁴Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, ⁵Manchester Academic Health Sciences Centre, Health e-Research Centre, Farr Institute for Health Informatics Research, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Glucocorticoid (GC) therapy is used widely in patients with inflammatory diseases. However their effectiveness is offset by a range of potential harms. Clinicians and…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].