Abstracts tagged "drug interactions and rheumatoid arthritis (RA)"

Abstract Number: 2751 • 2015 ACR/ARHP Annual Meeting
Assessment of the Effect of CYP3A Inhibition, CYP Induction, OATP1B Inhibition and Administration of High-Fat Meal on the Pharmacokinetics of the Potent and Selective JAK1 Inhibitor ABT-494
Mohamed-Eslam Mohamed¹, Steven Jungerwirth², Armen Asatryan¹, Ping Jiang² and Ahmed Othman¹, ¹AbbVie, North Chicago, IL, ²AbbVie Inc., North Chicago, IL
Background/Purpose: ABT‑494 is an oral selective JAK1 inhibitor that is being developed for treatment of rheumatoid arthritis and Crohn’s disease. ABT-494 is metabolized by cytochrome…

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Abstracts tagged "drug interactions and rheumatoid arthritis (RA)"

Assessment of the Effect of CYP3A Inhibition, CYP Induction, OATP1B Inhibition and Administration of High-Fat Meal on the Pharmacokinetics of the Potent and Selective JAK1 Inhibitor ABT-494