Abstracts tagged "drug interactions and pain management"

Abstract Number: 448 • ACR/ARHP Annual Meeting 2018
Tizanidine, a Frequently Used Muscle Relaxant, Is Associated with Severe Hypotension: Role of Cytochrome P450 1A2 Inhibition in Routine Clinical Practice
Sandip Chaugai¹, Alyson Dickson², Megan Shuey², QiPing Feng², Katherine Barker², James Luther², C. Michael Stein³ and Cecilia P. Chung³, ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN, ³Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Tizanidine, a muscle relaxant widely used for musculoskeletal pain, can lower blood pressure and is metabolized by the cytochrome P450 1A2 (CYP1A2). As a…