Abstracts tagged "doxycycline and inflammation"

Abstract Number: 1058 • 2018 ACR/ARHP Annual Meeting
Doxycycline Directly Scavenges Reactive Oxygen Species and Inhibits the Formation of Malondialdehyde-Acetaldehyde-Protein Adducts – a Novel Mechanism of Action for an Old Drug
Andrew Chiou¹, Michael J. Duryee¹, Dahn L Clemens², Cleofes Sarmiento², Matthew Zimmerman³, Carlos D. Hunter¹, Lynell W. Klassen⁴, James R. O'Dell⁴, Daniel R. Anderson², Ted R. Mikuls⁵ and Geoffrey M. Thiele², ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Omaha, NE, ³Cell Biology and Physiology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Oxidative stress plays a role in the progression of inflammatory diseases such as Rheumatoid Arthritis (RA) due to the imbalance between levels of reactive…

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