Abstracts tagged "DMARDs"

Abstract Number: 2095 • 2017 ACR/ARHP Annual Meeting
Traditional Disease Modifying Anti-Rheumatic Drugs (tDMARDs), Hydroxychloroquine (HCQ) and/or Sulfasalazine (SSZ), Are Rapidly Effective in Immune Checkpoint Inhibitors-Induced Inflammatory Arthritis
Jessie Alperin¹, Jeffrey Sarazin², Leslie Fecher³, Christopher Lao³, Seetha Monrad⁴, David Fox¹ and Elena Schiopu⁵, ¹University of Michigan Medical System, Ann Arbor, MI, ²Rheumatology, University of Michigan Medical System, Ann Arbor, MI, ³Oncology, University of Michigan Medical System, Ann Arbor, MI, ⁴Internal Medicine/Rheumatology, University of Michigan Medical System, Ann Arbor, MI, ⁵Internal Medicine, University of Michigan Medical System, Ann Arbor, MI
Background/Purpose: Immune checkpoint inhibitor (ICI) therapy is widely used in the treatment of metastatic melanoma and non-small cell lung cancer and it is under investigation…
Abstract Number: 206 • 2017 ACR/ARHP Annual Meeting
Real World IGRA Testing in Rheumatology Practice
Paul DeMarco^1,2, Megan Bishop³, Ashling Smith⁴, Herbert S. B. Baraf^1,5, Andrew Gregory DeMarco⁶, Temitope Ademola⁷, Deborah Contreras⁸, Adalisa Enriquez RMA¹, Lisa Klein¹, Kayra Perez¹, Sandra Ventura¹, Janice Whyte-Whitworth¹, Vince Calhoun¹, Theresa Bass Goldman¹ and Alan K Matsumoto^1,9, ¹The Center for Rheumatology and Bone Research, Wheaton, MD, ²Division of Rheumatology, Department of Medicine, Georgetown University School of Medicine, Washington, DC, ³Clinical Trials, The Center for Rheumatology and Bone Research, Wheaton, MD, ⁴2730 University Blvd West, Suite 306, The Center for Rheumatology and Bone Research, Wheaton, MD, ⁵Department of Medicine, George Washington University School of Medicine, Washington, DC, ⁶Department of Biochemistry and Molecular Cellular Biology, Georgetown University Department of Biochemistry and Molecular Cellular Biology, Washington, DC, ⁷The Center for Rheumatology and Bone Research, Washington, DC, ⁸2730 University Boulevard West, Suite 306, The Center for Rheumatology and Bone Research, Wheaton, MD, ⁹Department of Medicine, Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD
Background/Purpose: Mycobacterium tuberculosis (MTb) screening is routine for clinical trial protocols, & authorization for immunomodulators use by health insurances. Real world data is needed to…
Abstract Number: 1044 • 2017 ACR/ARHP Annual Meeting
Medical Care Costs Associated with Rheumatoid Arthritis in the US: A Meta-Analysis
Andrew Hresko¹, Tzu-Chieh Lin² and Daniel H. Solomon³, ¹Tufts Medical School, Boston, MA, ²Health Outcomes, Amgen, Thousand Oaks, CA, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) is a morbid, mortal, and costly condition without a cure. Treatments for RA have expanded over the last two decades…
Abstract Number: 2098 • 2017 ACR/ARHP Annual Meeting
Systemic Treatment for ACUTE Anterior Uveitis ( SYNTHETIC AND BIOLOGIC DISEASE-MODIFYINGANTIRHEUMATIC DRUGS) : A Systematic Literature Review
Alejandro Gómez-Gómez¹, Estibaliz Loza², Maria P Rosario³, Gerard Espinosa⁴, Jose M Ruiz de Morales⁵, Jose M Herreras⁶, Santiago Muñoz⁷ and Miguel Cordero-Coma⁸, ¹Hospital Universitario Infanta Sofía, Madrid, Spain, ²Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain, ³Instituto de Salud Musculoesquelética, Madrid, Spain, ⁴Autoimmune Diseases Department. Hospital Clínic de Barcelona, Barcelona, Spain, ⁵Complejo Asistencial Universitario de León, León, Spain, ⁶Ophthalmology, Hospital Universitario, IOBA, Valladolid, Spain, ⁷Rheumatology, Hospital Infanta Sofia, Madrid, Spain, ⁸Ophthalmology, Hospital de León. Spain, León, Spain
Background/Purpose: Acute anterior uveitis (AAU) is the most common form of uveitis. One third of AAU patients may present recurrences, some requiring systemic disease-modifying antirheumatic…
Abstract Number: 355 • 2017 ACR/ARHP Annual Meeting
Perceptions and Outcomes of Pregnancy and Lactation in Patients with Rheumatic Diseases
Brooke Mills¹, Kathryn H. Dao², Kristen Tecson², Emily Fishman³, Rachel Tate² and John J. Cush², ¹Internal Medicine, Baylor University Medical Center, Dallas, TX, ²Baylor Research Institute, Dallas, TX, ³Texas A&M HSC College of Medicine, Dallas, TX
Background/Purpose: Once diagnosed with a rheumatic disease, women often defer or avoid pregnancy or lactation, fearing adverse outcomes for their offspring or for themselves. Scant…
Abstract Number: 1100 • 2017 ACR/ARHP Annual Meeting
Communication between Inpatient and Outpatient Specialty Clinicians: Developing a Better Understanding of Patients with Rheumatoid Arthritis Who Are Admitted to the Hospital
Abraham Tacang¹, Christina Downey², Alfred Denio¹, Eric Newman³ and Lisa L. Schroeder⁴, ¹Rheumatology, Geisinger Medical Center, Danville, PA, ²Geisinger Medical Center, Danville, PA, ³Department of Rheumatology, Geisinger Medical Center, Danville, PA, ⁴Rheumatology, Geisinger Health System, Danville, PA
Background/Purpose: Effective communication is essential in caring for medically complex patients with rheumatoid arthritis (RA). Communication between clinicians becomes even more crucial when a patient…
Abstract Number: 2290 • 2017 ACR/ARHP Annual Meeting
Comparing Effectiveness of Early Initiation of Biologic Treatment for Newly Diagnosed Juvenile Idiopathic Arthritis Using a Novel Statistics Causal Inference Method Applied to Observational Data
Bin Huang¹, Esi Morgan², Chen Chen², Jinzhong Liu², Michelle Adams², Timothy Beukelman³, Hermine I. Brunner⁴ and Daniel J Lovell⁵, ¹Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Cincinnati Children's Hospital, Cincinnati, OH, ³Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵PRCSG, Cincinnati, OH
Background/Purpose: We compare the effectiveness of two approaches to treat Juvenile idiopathic arthritis (JIA): early combination of biologic and non-biologic disease modifying anti rheumatic drugs…
Abstract Number: 389 • 2017 ACR/ARHP Annual Meeting
S-110483 a New Potent EP4 Receptor Antagonist with Immunomodulatory and Analgesic Activities
Takashi Maeda¹, Toshitaka Ochiai², Toshie Nagayasu-Tanaka¹, Yuta Morisaki¹, Haruka Takizawa¹, Seiji Ishihara¹, Shigeo Kurokawa¹, Kiyoharu Ukai¹ and Masahiro Suda¹, ¹Pharmacology Department, Kaken Pharmaceutical Co., LTD, Kyoto, Japan, ²Kaken Pharmaceutical Co., LTD, Kyoto, Japan
Background/Purpose: Prostaglandin (PG) E2 is known to enhance the expansion of T helper 17 (Th17) cell population via EP4 receptor (EP4) in the early phase…
Abstract Number: 1159 • 2017 ACR/ARHP Annual Meeting
National Recommendations on the Use of Immunomodulatory Drugs in Patients with NON-Infectious NON-Malignant Anterior Uveitis
Gerard Espinosa¹, Santiago Muñoz², Jose M Ruiz de Morales³, Jose M Herreras⁴ and Miguel Cordero-Coma⁵, ¹Autoimmune Diseases Department. Hospital Clínic de Barcelona, Barcelona, Spain, ²Rheumatology, Hospital Infanta Sofia, Madrid, Spain, ³Complejo Asistencial Universitario de León, León, Spain, ⁴Ophthalmology, Hospital Universitario, IOBA, Valladolid, Spain, ⁵Ophthalmology, Hospital de León. Spain, León, Spain
Background/Purpose: Anterior uveitis (AU) is the most common pattern of uveitis, that migh lead to important ocular complications including blindness. Immunomodulatory drugs have been used…
Abstract Number: 2404 • 2017 ACR/ARHP Annual Meeting
Use of Dmards after the Diagnosis of Cancers in Patients with RA
Young Bin Joo, Yune-Jung Park, Ki-Jo Kim and Kyung-Su Park, Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, Republic of (South)
Background/Purpose: Although there are many studies about the association of disease-modifying anti-rheumatic drugs (DMARDs) with cancers in patients with rheumatoid arthritis (RA), there are few…
Abstract Number: 390 • 2017 ACR/ARHP Annual Meeting
S-110483, a Novel and Selective EP4 Receptor Antagonist with Anti-Bone Destruction Activities
Toshitaka Ochiai¹, Takashi Maeda², Toshie Nagayasu-Tanaka², Jun Anzai¹, Daiki Kato¹, Yuta Morisaki², Kiyoharu Ukai² and Masahiro Suda², ¹Kaken Pharmaceutical Co., LTD, Kyoto, Japan, ²Pharmacology Department, Kaken Pharmaceutical Co., LTD, Kyoto, Japan
Background/Purpose: S-110483 is our novel potent and selective EP4 receptor (EP4) antagonist. In addition to the well-known fact that EP4 antagonists have anti-inflammatory effects, it…
Abstract Number: 1311 • 2017 ACR/ARHP Annual Meeting
Pregnancy Outcome in Chinese Women with Rheumatic Disease Treated By Leflunomide (LEF)
Yan Zhao¹, lingxun shen², zongwen shuai³, Hengli Zhao⁴, Weinan Lai⁵, Xiaoling Lai⁶, Shaoying Zhang⁷, Xuequn Wang⁸, Shaoxian Hu⁹, Wenli Chen¹⁰, Wei Ji¹¹, Hua Wei¹², Qi Zhang¹³, Lixia Pang¹⁴, huaxiang Liu¹⁵, Qiang Shu¹⁵, Jun-li Zhang¹⁶, Yating Zhou¹⁷, Qiong Jiang¹⁸, Huaxiang Wu¹⁹, Jing Xue¹⁹, Ganping Bai²⁰, Li Zhang²¹ and Fei Xiao²¹, ¹Rheumatology, Peking Union Medical College Hospital, Beijing, China, ²Wuhan Union Hospital, wuhan, China, ³The First Affiliated Hospital of Anhui University, Hefei, China, ⁴Yantai Hospital of Traditional medicine University, Yantai, China, ⁵Nanfang Hospital, Guangzhou, China, ⁶Guangxi Hospital of Traditional Chinese Medicine, Nanning, China, ⁷Yiling Hospital, Yiling, China, ⁸The First Affiliated Hospital of Xinyang, Xinyang, China, ⁹Tongji hospital, wuhan, China, ¹⁰Wuhan Central Hospital, wuhan, China, ¹¹Jiangsu Province Hospital of TCM, Nanjing, China, ¹²Subei People's Hospital, Yangzhou, China, ¹³Dongying central hospital, Dongying, China, ¹⁴Dongying Hospital, Dongying, China, ¹⁵Qilu hospital of Shandong University, Jinan, China, ¹⁶Rheumatology, The Fifth Hospital of Xi’an City, Xi’an, China, ¹⁷Xian No5 Hospital, Shandong, China, ¹⁸Taizhou Hospital, Taizhou, China, ¹⁹The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, ²⁰Chongqing Southwest Hospital, Chongqing, China, ²¹Gothic Internet Technology Corporation, Shanghai, China
Background/Purpose: LEF is a first line DMARD. Due to the teratogenic effects in offspring of rats in preclinical study, the patients who plan to get…
Abstract Number: 2469 • 2017 ACR/ARHP Annual Meeting
Median Time to Lda Is Shorter in Tocilizumab Combination Therapy with Csdmards As Compared to Monotherapy in Patients with Active Rheumatoid Arthritis and Inadequate Responses to Csdmards and/or TNF Inhibitors: Sub-Analysis of the Swiss and Austrian Patients from the ACT-SURE Study
Ruediger Mueller¹, Winfried Graninger², Páris Sidiropoulos³, Christoph Goger⁴ and Johannes von Kempis⁵, ¹Rheumatology, MD, St. Gallen, Switzerland, ²Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ³F. Hoffmann-La Roche Ltd, South San Francisco, CA, ⁴Roche Austria GmbH, Vienna, Austria, ⁵Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland
Background/Purpose: To analyze efficacy and safety of tocilizumab in patients with rheumatoid arthritis (RA) and an inadequate response to conventional synthetic disease modifying anti-rheumatic drugs…
Abstract Number: 408 • 2017 ACR/ARHP Annual Meeting
CR6086 Is Highly Effective and Improves Methotrexate Effect in a Mouse Model of Rheumatoid Arthritis
Gianfranco Caselli¹, Flora Ferrari¹, Eleonora Comi¹, Marco Perrella¹, Camilla Recordati², Adriana Grotti¹, Rosanna Cavagnoli¹, Marco Lanza¹ and Lucio C. Rovati³, ¹Rottapharm Biotech, Monza, Italy, ²Mouse & Animal Pathology Lab,, Fondazione Filarete, Milano, Italy, Milano, Italy, ³Clinical Research Department, Rottapharm Biotech, Monza, Italy
Background/Purpose: CR6086, a selective EP4 antagonist, dose-dependently improves disease features in rheumatoid arthritis (RA) models in rodents. Indeed, recent studies highlight the role of the…
Abstract Number: 1316 • 2017 ACR/ARHP Annual Meeting
Risk of Preterm Delivery Associated with Perinatal Exposure to Dmards in Women with Inflammatory Arthritis: A Population-Based Cohort Study
Nicole W. Tsao^1,2, Eric C. Sayre², Mohsen Sadatsafavi¹, J. Antonio Avina-Zubieta^2,3, Stephanie Ensworth⁴ and Mary A. De Vera^1,2, ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Given the limited data on impacts of perinatal medication use, our objective was to investigate the association between conventional synthetic DMARD (csDMARD) use preconception…

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