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Abstracts tagged "Disease-modifying antirheumatic drugs"

  • Abstract Number: 479 • 2013 ACR/ARHP Annual Meeting

    Attainment Of Remission, Functional, and Quality Of Life Improvements With Golimumab Treatment In Rheumatoid Arthritis Are Associated With Patient Expectations

    B Dasgupta1, B Combe2, I Louw3, J Wollenhaupt4, C Zerbini5, A Beaulieu6, H Schulze-Koops7, P Durez8, V Wolff9, R Yao10, HH Weng10, M Govoni11 and N Vastesaeger12, 1Southend University Hospital, Westcliff-on-Sea, United Kingdom, 2Hôpital Lapeyronie, Montpellier, France, 3Panorama Medical Centre, Cape Town, South Africa, 4Schön-Klinik, Hamburg, Germany, 5Hospital Heliópolis, Serviço de Reumatologia, São Paulo, Brazil, 6Centre de Rhumatologie, St-Louis, QC, Canada, 7University of Munich, Munich, Germany, 8Université Catholique de Louvain and Cliniques Universitaires Saint-Luc, Brussels, Belgium, 9Hospital del Salvador, Santiago, Chile, 10Merck & Co., Inc., Whitehouse Station, NJ, 11MSD Italy, Rome, Italy, 12Merck Sharp & Dohme, Brussels, Belgium

    Background/Purpose: Golimumab (GLM) and other tumor necrosis factor antagonists are used as add-on therapy for patients with rheumatoid arthritis (RA) who have not responded to…
  • Abstract Number: 446 • 2013 ACR/ARHP Annual Meeting

    Remission Rates During Golimumab Treatment For Rheumatoid Arthritis Are Associated With Differences In Baseline Disease States Across Geographic Regions

    P Durez1, K Pavelka2, M Lazaro3, A Garcia Kutzbach4, R Moots5, H Amital6, R Yao7, M Govoni8,9, N Vastesaeger10 and HH Weng7, 1Université Catholique de Louvain and Cliniques Universitaires Saint-Luc, Brussels, Belgium, 2Revmatologicky Ustav, Praha, Czech Republic, 3IARI Instituto de Asistencia Reumatologica Integral, Buenos Aires, Argentina, 4AGAR Francisco Marroquin University, Guatemala City, Guatemala, 5University Hospital Aintree, Liverpool, United Kingdom, 6Sheba Medical Center, Tel-Hashomer, Israel, 7Merck & Co., Inc., Whitehouse Station, NJ, 8MSD Italy, Rome, Italy, 9Merck Sharp & Dohme, Rome, Italy, 10Merck Sharp & Dohme, Brussels, Belgium

    Background/Purpose: Regional differences in practice patterns and access to biologic treatment for rheumatoid arthritis (RA) may lead to regional differences in baseline disease characteristics, which…
  • Abstract Number: 343 • 2013 ACR/ARHP Annual Meeting

    Conventional Dmards For Psoriatic Arthritis: Data On 1351 Treatment Courses With Methotrexate, Sulfasalazine and Leflunomide

    Elisabeth Lie1, Karen M. Fagerli1, Erik Rødevand2, Synnøve Kalstad3, Knut Mikkelsen4, Ada Wierød5, Désirée van der Heijde6 and Tore K. Kvien1, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Dept. of Rheumatology, St. Olavs Hospital, Trondheim, Norway, 3Dept. of Rheumatology, University Hospital of Northern Norway, Tromsø, Norway, 4Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 5Dept. of Rheumatology, Vestre Viken Hospital Drammen, Drammen, Norway, 6Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Methotrexate (MTX), sulfasalazine (SSZ) and leflunomide (LEF) are recommended treatments for PsA patients with active peripheral arthritis. In the publication of a recent negative…
  • Abstract Number: 205 • 2013 ACR/ARHP Annual Meeting

    Temporal Trends In The Prescribing Of Disease Modifying Anti-Rheumatic Drugs For Rheumatoid Arthritis and The Impact Of Guidelines

    Gemma L Wallace1, C. J. Edwards2, Nigel K. Arden3, Daniel Prieto-Alhambra4 and Andrew Judge5, 1NDORMS, University of Oxford, Oxford, United Kingdom, 2Rheumatology, University Hospital Southampton, Southampton, United Kingdom, 3NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, 4Internal Medicine; Primary Care; NDORMS Dept; MRC Lifecourse Epidemiology Unit, URFOA-IMIM, Parc de Salut Mar; Idiap Jordi Gol; University of Oxford; University of Southampton, Barcelona, Spain, 5Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom

     Background/Purpose: Disease modifying anti-rheumatic drugs (DMARDs) are standard initial treatments for rheumatoid arthritis (RA).  Many RA treatment guidelines have been published including from the American…
  • Abstract Number: 187 • 2013 ACR/ARHP Annual Meeting

    The Health and Economic Consequences Of Delay In Starting Disease-Modifying Anti-Rheumatic Drugs In Australian Patients With Early Rheumatoid Arthritis

    Danny Liew, Mark Tacey and Sharon Van Doornum, Melbourne EpiCentre, The University of Melbourne, Melbourne, Australia

    Background/Purpose: Several international studies suggest that the time between symptom onset and DMARD initiation in RA patients is longer than is considered optimal. We sought…
  • Abstract Number: 2662 • 2012 ACR/ARHP Annual Meeting

    Tightening up: Musculoskeletal Ultrasound Could Further Individualise Treatment Decisions in Early Rheumatoid Arthritis Patients Treated by a Step-up DMARD Escalation Regimen

    James Dale1, David Purves2, Alex McConnachie2, Duncan Porter3 and Iain B. McInnes4, 1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom, 3Rheumatology, Gartnavel General Hospital, Glasgow, United Kingdom, 4Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Treat-to-target (T2T) strategies have significantly improved outcomes in early rheumatoid arthritis (RA). Treatment escalation is usually guided by a disease activity score; however, modern…
  • Abstract Number: 1840 • 2012 ACR/ARHP Annual Meeting

    Treatment Patterns in Psoriatic Arthritis Patients Newly Initiated On Non-Biologic Disease-Modifying Anti-Rheumatic Drugs

    Jeffrey R. Curtis1, Genevieve Gauthier2, Robert Hiscock2 and Frank Zhang3, 1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Analysis Group, Inc., Montreal, QC, Canada, 3Pricing and Market Access, I&I, Celgene Corporation, Warren, NJ

    Background/Purpose: Several treatment options are available for psoriatic arthritis (PsA) patients (pts). Oral disease modifying anti-rheumatic drugs (DMARDs) are often used as a first-line treatment…
  • Abstract Number: 1843 • 2012 ACR/ARHP Annual Meeting

    Predictors of Starting and Stopping Disease Modifying Anti-Rheumatic Drugs for Rheumatoid Arthritis: A 23 Year Longitudinal Cohort

    Daniel H. Solomon1, Edward H. Yelin2, Jeffrey N. Katz3, Chris Tonner4, M. Alan Brookhart5, Seoyoung C. Kim6, Bing Lu7 and John Z. Ayanian8, 1Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, 2Medicine, UC San Francisco, San Francisco, CA, 3Rheumatology and Orthopedics, Brigham & Women's Hospital, Boston, MA, 4Medicine, UCSF, San Francisco, CA, 5University of North Carolina, Chapel Hill, NC, 6Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 7Rheumatology, Brigham and Women's Hospital, Boston, MA, 8Brigham and Women's Hospital, Boston, MA

    Background/Purpose: DMARDs are the standard of care for rheumatoid arthritis (RA), however multiple studies find that not all patients use these agents.  We examined predictors…
  • Abstract Number: 1844 • 2012 ACR/ARHP Annual Meeting

    Inequities in Access to Biologic Disease-Modifying Anti-Rheumatic Drugs for Patients with Rheumatoid Arthritis Across 46 European Countries

    Polina Putrik1, Sofia Ramiro2, Milena Pavlova3, Tore K. Kvien4, Tuulikki Sokka5, Till Uhlig4, Annelies Boonen6 and Equity In Access To Treatment of RA Across Europe7, 1Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands and Hospital Garcia de Orta, Almada, Portugal, 3Health Services Research, Maastricht University, Maastricht, Netherlands, 4Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, 6Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 7European Region

    Background/Purpose: In the treatment of patients with RA, EULAR recommends to initiate biologic DMARDs after failing synthetic DMARDs. However, biologics are costly, and it is…
  • Abstract Number: 1845 • 2012 ACR/ARHP Annual Meeting

    Inequalities Across 46 European Countries in Clinical Eligibility Criteria for the Start of A First (Reimbursed) Biologic in Patients with Rheumatoid Arthritis

    Polina Putrik1, Sofia Ramiro2, Tore K. Kvien3, Tuulikki Sokka4, Till Uhlig3, Annelies Boonen5 and Equity in Clinical Eligibility Criteria for RA treatment6, 1Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands and Hospital Garcia de Orta, Almada, Portugal, 3Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, 5Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 6European Region

    Background/Purpose: In the treatment of patients with RA, strategies that include biologics have resulted in a better outcome for patients with regard to disease activity,…
  • Abstract Number: 1761 • 2012 ACR/ARHP Annual Meeting

    Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti-CD19 Monoclonal Antibody That Co-Engages the B Cell Antigen Receptor and the FcγRIIb Inhibitory Receptor

    Seung Y. Chu1, Karen Yeter2, Roshan Kotha3, Erik Pong1, Yvonne Miranda1, Hsing Chen1, Sung-Hyung Lee1, Irene Leung1, John R. Desjarlais1, William Stohl2 and David E. Szymkowski4, 1Xencor, Inc., Monrovia, CA, 2Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 3Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 4Biotherapeutics, Xencor, Inc., Monrovia, CA

    Background/Purpose: XmAb®5871 is a humanized and Fc-engineered antibody that coengages CD19, part of the B cell receptor (BCR) complex, with the inhibitory receptor FcγRIIb (CD32b).…
  • Abstract Number: 1374 • 2012 ACR/ARHP Annual Meeting

    Value of C-Reactive Protein Level At Diagnosis of Psoriatic Arthritis in Predicting the Future Need for Treatment with Tumor Necrosis Factor-á Inhibitors

    Yair Molad1 and Shachaf Ofer-Shiber2, 1Rheumatology Unit, Beilinson Hospital, Rabin Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Petach-Tikva, Israel, 2Internal Medicine H, Beilinson Hospital, Rabin Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel

    Background/Purpose: To determine the value of acute-phase reactant levels at diagnosis of psoriatic arthritis in predicting the risk of failure of conventional treatment with disease-modifying…
  • Abstract Number: 1328 • 2012 ACR/ARHP Annual Meeting

    The Higher and Faster Increasing Schedule of Methotrexate May Not Be the Best: The Accumulation of Intracellular Longer Chain Methotrexate Polyglutamates Was Facilitated by the Extra-Low-Dose Methotrexate Treatment

    Yoshinobu Koyama1, Kazunori Hase2, Daisuke Hidaka2, Shuji Nagano3, Toshiyuki Ota3 and Ayumi Uchino2, 1Division of Rheumatology, Okayama Red Cross General Hospital, Okayama, Japan, 2Iizuka Hospital, Iizuka, Japan, 3Center for Rheumatic Diseases, Iizuka Hospital, Iizuka, Japan

    Background/Purpose: Although data are conflicting with regard to the clinical utility of MTX polyglutamates (PGs) measurements as a predictor of the efficacy or toxicity in…
  • Abstract Number: 1274 • 2012 ACR/ARHP Annual Meeting

    Relationship Between Morning Stiffness Duration and Severity, Pain Intensity, and Measures of Disease Activity in a 12 Week Efficacy Study of a Modified (Delayed-Release) Prednisone Plus Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis

    Frank Buttgereit1, John R. Kirwan2, Kenneth G. Saag3, Reike Alten4, Amy Grahn5, Patricia Rice6 and Maarten Boers7, 1Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, United Kingdom, 3Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, 4Charité Univ Medicine, Berlin, Germany, 5Clinical Development, Horizon Pharma, Inc, Deerfield, IL, 6Statistics, CliniRx Research, Naperville, IL, 7Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: RA patients typically present with pain and morning stiffness (MS).  MS is predictive of both functional disability and escalated RA care, but the best…
  • Abstract Number: 404 • 2012 ACR/ARHP Annual Meeting

    Remission is a Difficult Target in Clinical Practice When RA Disease Is Established

    Till Uhlig1, Elisabeth Lie2, Cecillie Kaufmann3, Erik Rødevand4, Knut Mikkelsen5, Synnøve Kalstad6 and Tore K. Kvien1, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Rheumatology department, Vestre Viken, Drammen, Norway, 4Dept. of Rheumatology, St. Olavs Hospital, Trondheim, Norway, 5Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 6Dept. of Rheumatology, University Hospital of Northern Norway, Tromsø, Norway

    Background/Purpose: Clinical remission is the treatment target in rheumatoid arthritis (RA) and several composite indices are available for evaluation of remission and low disease activity…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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