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Abstracts tagged "Disease-modifying antirheumatic drugs"

  • Abstract Number: 205 • 2013 ACR/ARHP Annual Meeting

    Temporal Trends In The Prescribing Of Disease Modifying Anti-Rheumatic Drugs For Rheumatoid Arthritis and The Impact Of Guidelines

    Gemma L Wallace1, C. J. Edwards2, Nigel K. Arden3, Daniel Prieto-Alhambra4 and Andrew Judge5, 1NDORMS, University of Oxford, Oxford, United Kingdom, 2Rheumatology, University Hospital Southampton, Southampton, United Kingdom, 3NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, 4Internal Medicine; Primary Care; NDORMS Dept; MRC Lifecourse Epidemiology Unit, URFOA-IMIM, Parc de Salut Mar; Idiap Jordi Gol; University of Oxford; University of Southampton, Barcelona, Spain, 5Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom

     Background/Purpose: Disease modifying anti-rheumatic drugs (DMARDs) are standard initial treatments for rheumatoid arthritis (RA).  Many RA treatment guidelines have been published including from the American…
  • Abstract Number: 187 • 2013 ACR/ARHP Annual Meeting

    The Health and Economic Consequences Of Delay In Starting Disease-Modifying Anti-Rheumatic Drugs In Australian Patients With Early Rheumatoid Arthritis

    Danny Liew, Mark Tacey and Sharon Van Doornum, Melbourne EpiCentre, The University of Melbourne, Melbourne, Australia

    Background/Purpose: Several international studies suggest that the time between symptom onset and DMARD initiation in RA patients is longer than is considered optimal. We sought…
  • Abstract Number: 2339 • 2013 ACR/ARHP Annual Meeting

    Patient Evaluations Of Subcutaneous Golimumab Delivery By Autoinjector (SmartJect®) For Treatment Of Rheumatoid Arthritis

    H Schulze-Koops1, R Giacomelli2, W Samborski3, S Rednic4, M Herold5, R Yao6, M Govoni7, N Vastesaeger8 and HH Weng6, 1University of Munich, Munich, Germany, 2Università degli Studi dell'Aquila, L'Aquila, Italy, 3Ortopedyczno-Rehabilitacyjny Szpital Kliniczny, Wielkopolskie, Poland, 4University of Medicine & Pharmacy, Cluj-Napoca, Romania, 5Internal Medicine VI, Medical University of Innsbruck, Innsbruck, Austria, 6Merck & Co., Inc., Whitehouse Station, NJ, 7MSD Italy, Rome, Italy, 8Merck Sharp & Dohme, Brussels, Belgium

    Background/Purpose: Self-injection of subcutaneous (SC) golimumab (GLM) using an autoinjector device may be useful for patients with rheumatoid arthritis (RA), especially if they have functional…
  • Abstract Number: 2283 • 2013 ACR/ARHP Annual Meeting

    The Evolving Use Of Biologic Monotherapy In Rheumatoid Arthritis and Its Impact On Patient Outcomes

    Laurent Chanroux, Katrina Johnson and Joan Casellas, Therapy Watch, The Research Partnership, London, United Kingdom

    Background/Purpose: The aim of our study is to understand whether the use of biologic monotherapy among rheumatoid arthritis (RA) patients is increasing and whether this…
  • Abstract Number: 1460 • 2013 ACR/ARHP Annual Meeting

    10 Years Of Treat-To-Target Therapy In Rheumatoid Arthritis Patients (the BeSt study): Clinical and Radiological Outcomes

    I.M. Markusse1, G. Akdemir1, M. van den Broek1, L. Dirven1, R.J. Goekoop2, K.H. Han3, M. van Oosterhout4, P.J.S.M. Kerstens5, W.F. Lems6, T.W.J. Huizinga1 and C.F. Allaart1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Haga Hospital, The Hague, Netherlands, 3Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 4Rheumatology, Groene Hart Hospital, Gouda, Netherlands, 5Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 6Rheumatology, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Long term studies with treat-to-target therapy are essential to guide treatment strategies. We report on a study that compared clinical and radiological outcomes of…
  • Abstract Number: 1840 • 2012 ACR/ARHP Annual Meeting

    Treatment Patterns in Psoriatic Arthritis Patients Newly Initiated On Non-Biologic Disease-Modifying Anti-Rheumatic Drugs

    Jeffrey R. Curtis1, Genevieve Gauthier2, Robert Hiscock2 and Frank Zhang3, 1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Analysis Group, Inc., Montreal, QC, Canada, 3Pricing and Market Access, I&I, Celgene Corporation, Warren, NJ

    Background/Purpose: Several treatment options are available for psoriatic arthritis (PsA) patients (pts). Oral disease modifying anti-rheumatic drugs (DMARDs) are often used as a first-line treatment…
  • Abstract Number: 1843 • 2012 ACR/ARHP Annual Meeting

    Predictors of Starting and Stopping Disease Modifying Anti-Rheumatic Drugs for Rheumatoid Arthritis: A 23 Year Longitudinal Cohort

    Daniel H. Solomon1, Edward H. Yelin2, Jeffrey N. Katz3, Chris Tonner4, M. Alan Brookhart5, Seoyoung C. Kim6, Bing Lu7 and John Z. Ayanian8, 1Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, 2Medicine, UC San Francisco, San Francisco, CA, 3Rheumatology and Orthopedics, Brigham & Women's Hospital, Boston, MA, 4Medicine, UCSF, San Francisco, CA, 5University of North Carolina, Chapel Hill, NC, 6Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 7Rheumatology, Brigham and Women's Hospital, Boston, MA, 8Brigham and Women's Hospital, Boston, MA

    Background/Purpose: DMARDs are the standard of care for rheumatoid arthritis (RA), however multiple studies find that not all patients use these agents.  We examined predictors…
  • Abstract Number: 1844 • 2012 ACR/ARHP Annual Meeting

    Inequities in Access to Biologic Disease-Modifying Anti-Rheumatic Drugs for Patients with Rheumatoid Arthritis Across 46 European Countries

    Polina Putrik1, Sofia Ramiro2, Milena Pavlova3, Tore K. Kvien4, Tuulikki Sokka5, Till Uhlig4, Annelies Boonen6 and Equity In Access To Treatment of RA Across Europe7, 1Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands and Hospital Garcia de Orta, Almada, Portugal, 3Health Services Research, Maastricht University, Maastricht, Netherlands, 4Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, 6Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 7European Region

    Background/Purpose: In the treatment of patients with RA, EULAR recommends to initiate biologic DMARDs after failing synthetic DMARDs. However, biologics are costly, and it is…
  • Abstract Number: 1845 • 2012 ACR/ARHP Annual Meeting

    Inequalities Across 46 European Countries in Clinical Eligibility Criteria for the Start of A First (Reimbursed) Biologic in Patients with Rheumatoid Arthritis

    Polina Putrik1, Sofia Ramiro2, Tore K. Kvien3, Tuulikki Sokka4, Till Uhlig3, Annelies Boonen5 and Equity in Clinical Eligibility Criteria for RA treatment6, 1Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands and Hospital Garcia de Orta, Almada, Portugal, 3Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, 5Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 6European Region

    Background/Purpose: In the treatment of patients with RA, strategies that include biologics have resulted in a better outcome for patients with regard to disease activity,…
  • Abstract Number: 1761 • 2012 ACR/ARHP Annual Meeting

    Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti-CD19 Monoclonal Antibody That Co-Engages the B Cell Antigen Receptor and the FcγRIIb Inhibitory Receptor

    Seung Y. Chu1, Karen Yeter2, Roshan Kotha3, Erik Pong1, Yvonne Miranda1, Hsing Chen1, Sung-Hyung Lee1, Irene Leung1, John R. Desjarlais1, William Stohl2 and David E. Szymkowski4, 1Xencor, Inc., Monrovia, CA, 2Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 3Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 4Biotherapeutics, Xencor, Inc., Monrovia, CA

    Background/Purpose: XmAb®5871 is a humanized and Fc-engineered antibody that coengages CD19, part of the B cell receptor (BCR) complex, with the inhibitory receptor FcγRIIb (CD32b).…
  • Abstract Number: 1374 • 2012 ACR/ARHP Annual Meeting

    Value of C-Reactive Protein Level At Diagnosis of Psoriatic Arthritis in Predicting the Future Need for Treatment with Tumor Necrosis Factor-á Inhibitors

    Yair Molad1 and Shachaf Ofer-Shiber2, 1Rheumatology Unit, Beilinson Hospital, Rabin Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Petach-Tikva, Israel, 2Internal Medicine H, Beilinson Hospital, Rabin Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel

    Background/Purpose: To determine the value of acute-phase reactant levels at diagnosis of psoriatic arthritis in predicting the risk of failure of conventional treatment with disease-modifying…
  • Abstract Number: 1328 • 2012 ACR/ARHP Annual Meeting

    The Higher and Faster Increasing Schedule of Methotrexate May Not Be the Best: The Accumulation of Intracellular Longer Chain Methotrexate Polyglutamates Was Facilitated by the Extra-Low-Dose Methotrexate Treatment

    Yoshinobu Koyama1, Kazunori Hase2, Daisuke Hidaka2, Shuji Nagano3, Toshiyuki Ota3 and Ayumi Uchino2, 1Division of Rheumatology, Okayama Red Cross General Hospital, Okayama, Japan, 2Iizuka Hospital, Iizuka, Japan, 3Center for Rheumatic Diseases, Iizuka Hospital, Iizuka, Japan

    Background/Purpose: Although data are conflicting with regard to the clinical utility of MTX polyglutamates (PGs) measurements as a predictor of the efficacy or toxicity in…
  • Abstract Number: 1274 • 2012 ACR/ARHP Annual Meeting

    Relationship Between Morning Stiffness Duration and Severity, Pain Intensity, and Measures of Disease Activity in a 12 Week Efficacy Study of a Modified (Delayed-Release) Prednisone Plus Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis

    Frank Buttgereit1, John R. Kirwan2, Kenneth G. Saag3, Reike Alten4, Amy Grahn5, Patricia Rice6 and Maarten Boers7, 1Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, United Kingdom, 3Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, 4Charité Univ Medicine, Berlin, Germany, 5Clinical Development, Horizon Pharma, Inc, Deerfield, IL, 6Statistics, CliniRx Research, Naperville, IL, 7Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: RA patients typically present with pain and morning stiffness (MS).  MS is predictive of both functional disability and escalated RA care, but the best…
  • Abstract Number: 404 • 2012 ACR/ARHP Annual Meeting

    Remission is a Difficult Target in Clinical Practice When RA Disease Is Established

    Till Uhlig1, Elisabeth Lie2, Cecillie Kaufmann3, Erik Rødevand4, Knut Mikkelsen5, Synnøve Kalstad6 and Tore K. Kvien1, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Rheumatology department, Vestre Viken, Drammen, Norway, 4Dept. of Rheumatology, St. Olavs Hospital, Trondheim, Norway, 5Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 6Dept. of Rheumatology, University Hospital of Northern Norway, Tromsø, Norway

    Background/Purpose: Clinical remission is the treatment target in rheumatoid arthritis (RA) and several composite indices are available for evaluation of remission and low disease activity…
  • Abstract Number: 211 • 2012 ACR/ARHP Annual Meeting

    Efficacy and Safety of Disease Modifying Drugs, Biologic Therapies and Immunoglobulin in Patients with Polymyositis and Dermatomyositis: A Systematic Literature Review

    JA Martinez-Lopez Sr.1, J. Graña Sr.2, Santiago Muñoz-Fernandez3, I. Rua-Figueroa4, José M. Pego-Reigosa5, Estíbaliz Loza Sr.6 and SER group for the study of systemic autoimmune diseases7, 1Fundacion Jimenez Diaz, Madrid, Spain, 2Hospital Juan Canalejo, Spain, 3Unit Rheumatology, Hospital Infanta Sofía, Madrid, Spain, 4Rheumatology, Hospital de GC Dr Negrin, Las Palmas GC, Spain, 5Rheumatology, Hospital do Meixoeiro, Vigo, Spain, 6Research Unit. Sociedad Española de Reumatología, Madrid, Spain, 7Madrid

    Background/Purpose: The aim of this study was to systematically review the efficacy and safety of available drugs in patients with polymyositis (PM) or dermatomyositis (DM)Methods:…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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