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Abstracts tagged "Disease-Modifying Antirheumatic Drugs (Dmards)"

  • Abstract Number: 1336 • ACR Convergence 2025

    Effectiveness of new initiators of tofacitinib and other biologic/targeted synthetic DMARDs in patients with rheumatoid arthritis

    Katherine Liao1, Chandrasekar Gopalakrishnan2, Jinoos Yazdany3, Griffith Bell4, Suraj Mothi5, Genevieve Gauthier6, Arne Yndestad7 and Milena Gianfrancesco8, 1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, Boston, MA, USA, Boston, MA, 2OM1 Inc, Boston, MA, USA, Boston, 3UCSF, San Francisco, CA, 4Pfizer Inc, New York, NY, USA, Boston, MA, 5OM1 Inc, Boston, MA, USA, Boston, MA, 6Pfizer Canada ULC, Kirkland, QC, Canada, Montreal, Canada, 7Pfizer Inc, Oslo, Norway, Oslo, Norway, 8Pfizer Inc, New York, NY, USA, New York, NY

    Background/Purpose: Though the efficacy and safety profile of tofacitinib in RA has been established in prior trials, the effectiveness of tofacitinib in routine care settings…
  • Abstract Number: 1088 • ACR Convergence 2025

    Unsupervised characterization of immune checkpoint inhibitor induced inflammatory arthritis using cluster and latent class analysis: result from a multicenter prospective registry

    Alice Tison1, Deanna Jannat-Khah2, Laura Cappelli3 and Anne R. Bass2, 1LBAI, UMR1227, University of Brest, CHU Brest, Brest, France, Brest, France, 2Hospital For Special Surgery, New York, NY, 3Johns Hopkins School of Medicine, Baltimore, MD

    Background/Purpose: The broad use of immune checkpoint inhibitors (ICIs) in oncology has led to the emergence of ICI-induced inflammatory arthritis (ICI-IA). The aim of this…
  • Abstract Number: 0557 • ACR Convergence 2025

    Efficacy of Upadacitinib in Male and Female Patients with PsA: Results from the SELECT-PsA 1 and 2 Trials

    Lihi Eder1, Axel Hueber2, Lucia Novelli3, Tianming Gao3, Jayne Stigler4, Zhiyuan Du3, Rodrigo García Salinas5, Grace Wright6 and Sofia Ramiro7, 1University of Toronto, Toronto, ON, Canada, 2Klinikum Nuernberg, Nuernberg, Germany, 3AbbVie, North Chicago, IL, 4AbbVie, Round Lake, IL, 5Hospital Italiano La Plata, La Plata, Argentina, 6Grace C Wright MD PC, New York, NY, 7Leiden University Medical Center, Bunde, Netherlands

    Background/Purpose: Biologic sex can impact both clinical phenotype and therapeutic response in PsA.1–3 Previous studies have suggested that male patients (pts) may achieve better treatment…
  • Abstract Number: 0484 • ACR Convergence 2025

    Comparable Efficacy of FK-Tocilizumab and Reference Tocilizumab in Rheumatoid Arthritis Patients With and Without Prior Biologic Exposure

    Ernest Choy1, Marco Gattorno2, Kamila Klama3, Andras Illes4, Peter Baker5, Maria Romanova Michailidi6 and Anna Zubrzycka-Sienkiewicz7, 1Division of Infection and Immunity, CREATE Centre, Cardiff University, Cardiff, United Kingdom, 2IRCCS G. Gaslini, Genova, Genoa, Italy, 3Solumed Clinical Research Center, Poznan, Poland, 4Fresenius Kabi SwissBioSim, Eysin, Switzerland, 5Fresenius Kabi Biopharma, Eysins, Switzerland, 6University of Geneva, Eysins, Switzerland, 7Reumatika - Centrum Reumatologii, Warszawa, Poland

    Background/Purpose: Biosimilars offer comparable efficacy and safety to their originators, thereby improving patient access to affordable treatments. FK-Tocilizumab (FK-toci) is the first tocilizumab biosimilar approved…
  • Abstract Number: 0072 • ACR Convergence 2025

    Impact of Baricitinib on Cardiovascular Health in Biologic-naïve Rheumatoid Arthritis patients: A Comparative Study with TNF Inhibitors and Conventional DMARDs

    Chary López pedrera1, Laura muñoz-Barrera2, Rafaela Ortega-Castro3, Sagrario Corrales2, Jerusalen Calvo Gutierrez4, Concepción Aranda Valera5, Lourdes Ladehesa6, Pilar Font7, Ismael Sanchez-Pareja2, Elena Moreno-Caño5, M Carmen Abalos-Aguilera8, Christian Merlo-Ruiz8, MARIA ANGELES AGUIRRE ZAMORANO2, Pedro Seguí-Azpilcueta9, Tomás Cerdó2, Nuria Barbarroja10, Rocío González Conejero11, Constantino Martínez11, Carlos Pérez Sánchez12 and Alejandro Escudero13, 1Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Spain, 2Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Spain, 3Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Andalucia, Spain, 4Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Sevilla, Spain, 5IMIBIC-Reina Sofia Hospital-University of Cordoba, Cordoba, Spain, Córdoba, Spain, 6IMIBIC-Reina Sofia Hospital-University of Cordoba, Cordoba, Spain, Cordoba, Spain, 7Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, SpainBiomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Spain, 8Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Spain, 9Radiology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba/University of Cordoba, Spain, Córdoba, United Kingdom, 10Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain, 11Servicio de Hematología, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB Pascual Parrilla., Murcia, Spain, 12Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/ CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain, 13Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Andalucia, Spain

    Background/Purpose: Therapeutic advances in RA have introduced effective treatments, including b/tsDMARDs such as Baricitinib. However, its cardiovascular safety profile remains unclear, partly due to the…
  • Abstract Number: 2642 • ACR Convergence 2025

    Impact of Rheumatoid Arthritis Therapeutic Classes on Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism: A Population-Based Cohort Study

    Mohammad Movahedi1, Angela Cesta1, Sibel Aydin2, Pooneh Akhavan3, Tetyana Kendzerska4, Claire Bombardier1 and Bindee Kuriya5, 1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Department of Medicine, University of Ottawa, The Ottawa Hospital Research Institute, Ottawa, ON, Canada, 3self-employed, Toronto, ON, Canada, 4Ottawa Hospital Research Institute, Mississuaga, ON, Canada, 5University of Toronto - Toronto, Toronto, ON, Canada

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk of major adverse cardiovascular events (MACE) and venous thromboembolism (VTE). Inflammation is a driver of…
  • Abstract Number: 2267 • ACR Convergence 2025

    Impact of Baseline Cardiovascular Risk Factors Comorbidities on an Adalimumab Biosimilar Efficacy, Quality of Life and Safety In Patients with Patients with Moderately to Severely Active Rheumatoid Arthritis: Results from the AURIEL-RA study

    Chris Edwards1, Janet Pope2, Joelle Monnet3 and Maria Romanova Michailidi4, 1University Hospital Southampton, Southampton, United Kingdom, 2University of Western Ontario, London, ON, Canada, 3Fresenius Kabi SwissBioSim, Eysins, Switzerland, 4University of Geneva, Eysins, Switzerland

    Background/Purpose: RA has been associated with an increase risk of cardiovascular morbidity and mortality1. The present analysis was performed to assess the efficacy (on ACR…
  • Abstract Number: 1586 • ACR Convergence 2025

    Real-World Safety and Efficacy of JAK Inhibitors in Systemic Sclerosis: A Propensity-Matched EUSTAR Study

    Stefano Di Donato1, Marie-Elise Truchetet2, Marco Minerba3, Oliver Distler4, JUAN JOSE ALEGRE SANCHO5, Yolanda Braun Moscovici6, Christina Bergmann7, Petros Sfikakis8, Jeska de Vries-Bouwstra9, Murray Baron10, Silvia Bellando-Randone11, Lorenzo Dagna12, Christopher Denton13, Madelon Vonk14, Vanessa Smith15, Ivan Castellvi16, Gabriela Riemekasten17, Andra Balanescu18, Masataka Kuwana19, Maria De Santis20, Kamal Solanki21, Anastas Batalov22, Vahan Mukuchyan23, Marco Matucci-Cerinic24, Yannick Allanore25, Francesco Del Galdo26 and Michael Hughes27, 1University of Leeds, Canosa Sannita, Chieti, Italy, 2Bordeaux University Hospital, Bordeaux, France, 3Campus Bio-Medico University of Rome, Taranto, Taranto, Italy, 4Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland, 5Department of rheumatology. Hospital Universitario Doctor Peset, Valencia, Spain, 6Rambam Heath Care Campus, Haifa, Israel, 7Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, 8NKUA - SCHOOL OF MEDICINE, Athens, Greece, 9Leiden University Medical Center, Leiden, Netherlands, 10Self employed, Montréal, Canada, 11University of Florence, Florence, Florence, Italy, 12Ospedale San Raffaele, Milano, Italy, 13University College London, UK, London, United Kingdom, 14Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 15Ghent University Hospital, Gent, Belgium, 16Hospital Universitari de la Santa Creu i Sant Pau, Sant Just Desvern, Spain, 17University Clinic Schleswit-Holstein (UKSH), Lübeck, Germany, 18UNIVERSITY OF MEDICINE AND PHARMACY CAROL DAVILA, Bucharest, Romania, 19Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 20Humanitas University, Pieve Emanuele, Italy, 21Waikato Hospital, Hamilton, New Zealand, 22Medical University of Plovdiv, Plovdiv, Bulgaria, 23"Erebuni" Medical Center, Yerevan, Armenia, 24University San Raffaele Milano, Milano, Milan, Italy, 25Université Paris Cité, Paris, France, 26University of Leeds, Leeds, United Kingdom, 27Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK, Manchester, England, United Kingdom

    Background/Purpose: Systemic sclerosis (SSc) is a complex systemic autoimmune disease characterized by vasculopathy, fibrosis, and immune dysregulation. While JAK inhibitors (JAKi) have shown promising immunomodulatory…
  • Abstract Number: 1329 • ACR Convergence 2025

    Relationship Between Circulating Bacterial Small RNAs, Methotrexate Response, and Microbiome in New Onset Rheumatoid Arthritis

    Carolina Ramirez-Becerra1, Tulsi Joishy2, Sheau-Chiann Chen2, Marisol Ramirez-Solano2, Quanhu Sheng2, Peter Turnbaugh3, Carles Ubeda4, Renuka Nayak5, Rebecca Blank6, Jose Scher7 and Michelle Ormseth2, 1Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, 3University of California, San Francisco, San Francisco, CA, 4Fisabio, Madrid, 5University of California, San Francisco (UCSF), San Francisco, CA, 6NYU Langone Health, New York, NY, 7New York University School of Medicine, New York, NY

    Background/Purpose: Microbiome and microbial products are possible contributors and predictors to methotrexate (MTX) response variability. Bacterial small RNAs (sRNAs) are found in human plasma and…
  • Abstract Number: 1061 • ACR Convergence 2025

    Screening for Hepatitis B in a Veterans Health Administration Subpopulation with Rheumatological Disease Prior to Initiating Immunosuppressive Therapy: a retrospective study on testing and treatment within the Black American population from the VAMC in Memphis, TN

    Daniel Austin1, Beenish Zulfiqar2, Akhil Adla1, Jeffrey Zuber2 and Joshua Sullivan3, 1University of Tennessee Health Science Center, Memphis, TN, 2University of Tennessee Health Science Center & Lt. Col. Luke J. Weathers, Jr. VA Medical Center, Memphis, TN, Memphis, TN, 3Lt. Col. Luke J. Weathers, Jr. VA Medical Center, Memphis, TN, Memphis, TN

    Background/Purpose: Hepatitis B virus (HBV) screening is insufficiently completed prior to initiation of immunosuppressive therapy nationwide. Various factors including alert fatigue, provider mistakes, non-compliance, and…
  • Abstract Number: 0554 • ACR Convergence 2025

    Real world experience with generic Tofacitinib in Axial Spondyloarthritis from North India

    Sanjeev Kapoor1, Babita Bondage1, Niti Kedia1, Mariya Patel1 and Akanksha Kapoor2, 1Indian Spinal Injuries Centre (ISIC), New Delhi, India, 2Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Pune, India

    Background/Purpose: Axial spondyloarthritis (AxSpA) is an inflammatory condition that falls under the category of spondyloarthritis (SpA) and significantly affects quality of life, causing symptoms like…
  • Abstract Number: 0483 • ACR Convergence 2025

    Safety of JAK inhibitors (JAKi) in chronic inflammatory arthritis (CIA): an observational study

    Clara De Miguel1, Héctor Vega2, Marta Sánchez2, Esther Toledano3, Pedro Pablo Bermejo4, Leonor Laredo5, José Alberto Peña6, María Teresa Benítez7, DALIFER FREITES8, LETICIA LEON9 and lydia Abasolo Alcazar10, 1Rheumatology Service, San Carlos Clinical Hospital, Madrid, Spain, 2Complutense University of Madrid, Madrid, Spain, 3Rheumatology Service, San Carlos Clinical Hospital, Madrid, Spain, 4Clinical Pharmacology Service, San Carlos Clinical Hospital, MADRID, Madrid, Spain, 5Hospital Clinico San Carlos, MADRID, Madrid, Spain, 6Pharmacy Service San Carlos Clinical Hospital, MADRID, Madrid, Spain, 7San Carlos Clinical Hospital, MADRID, Madrid, Spain, 8Rheumatology Service, San Carlos Clinical Hospital, Madrid, Madrid, Spain, 9Fundación Investigación Biomédica Hospital Clínico San Carlos, IdISSC; Universidad Camilo Jose Cela, MADRID, Madrid, Spain, 10IdISSC. HCSC, Madrid, Madrid, Spain

    Background/Purpose: Rheumatoid arthritis (RA), psoriatic arthritis (PsA), and spondyloarthritis (SpA) are chronic inflammatory arthritis (CIAs). Janus kinase inhibitors (JAKis) have emerged as a promising therapeutic…
  • Abstract Number: 0070 • ACR Convergence 2025

    Integrating Synovial Protein Signatures and Serum Profiles to Predict Disease Activity and Treatment Response in Early Rheumatoid Arthritis

    Chary López pedrera1, Sagrario Corrales2, Julio Osuna3, Rafaela Ortega-Castro4, Jerusalén Calvo5, Lourdes Ladehesa6, Ismael Sanchez-Pareja2, Laura muñoz-Barrera2, Desiree Ruiz-Vilchez7, Christian Merlo8, MARIA ANGELES AGUIRRE ZAMORANO2, Nuria Barbarroja9, Tomás Cerdó2, Marta Alarcon-Riquelme10, Carlos Pérez Sánchez11, Alejandro Escudero Contreras5 and Concepción Aranda-Valera5, 1Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Spain, 2Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Spain, 3IMIBIC/Reina Sofia Hospital/University of Cordoba, Spain., Córdoba, Republic of Korea, 4Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Andalucia, Spain, 5IMIBIC / Reina Sofia Hospital / University of Cordoba, Córdoba, Spain, 6IMIBIC-Reina Sofia Hospital-University of Cordoba, Cordoba, Spain, Cordoba, Spain, 7Department of Rheumatology, Reina Sofía University Hospital / Maimonides Institute for Biomedical Research of Córdoba (IMIBIC) / Department of Medical and Surgical Sciences, Faculty of Medicine, University of Córdoba, Spain, Cordoba, Spain, 8Rheumatology Service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain, Cordoba, Spain, 9Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain, 10Fundación Progreso y Salud, Andalusian Government, Granada, Spain, 11Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/ CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain

    Background/Purpose: The analysis of synovial tissue has been instrumental in advancing our understanding of Rheumatoid Arthritis (RA) pathogenesis. As an alternative, the identification of serum…
  • Abstract Number: L09 • ACR Convergence 2024

    Efficacy and Safety of Tofacitinib in Patients with Active Systemic Juvenile Idiopathic Arthritis

    Hermine Brunner1, Caifeng Li2, Kogie Chinniah3, Yosef Uziel4, Olga Synoverska5, Sujata Sawhney6, Inmaculada Calvo Penades7, Ingrid Clara Louw8, Meiping Lu9, Pooja Nikunj Patel10, Pamela F. Weiss11, Cheng Chang12, Ivana Vranic13, Shixue Liu14, Annette Diehl15, Jose L. Rivas16, Carol A. Connell17, Gary G. Koch18, Alberto Martini19, Daniel J. Lovell1, Nicolino Ruperto20 and the PRINTO and PRCSG investigators, 1Cincinnati Children’s Hospital Medical Center, and University of Cincinnati, Cincinnati, OH, 2Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Bejing, China, 3Department of Paediatrics and Child Health, University of Kwa-Zulu, and Enhancing Care Foundation, Durban, South Africa, 4Pedriatric Rheumatology Unit, Department of Pediatrics, Meir Medical Center and Israel Tel Aviv University School of Medicine, Kfar Saba, Israel, 5Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine, 6Sir Ganga Ram Hospital, New Delhi, India, 7Hospital Universitario y Politécnico La Fe, Valencia, Spain, 8Panorama Medical Centre, Cape Town, South Africa, 9Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China, 10Ann & Robert H. Lurie Children’s Hospital of Chicago; Northwestern University School of Medicine, Chicago, IL, 11Division of Rheumatology, Children's Hospital of Philadelphia, and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 12Pfizer Inc, New York, NY, 13Pfizer Ltd, Tadworth, United Kingdom, 14Pfizer Inc, Shanghai, China, 15Pfizer Inc, Collegeville, PA, 16Pfizer SLU, Madrid, Spain, 17Pfizer Inc, Groton, CT, 18University of North Carolina at Chapel Hill, Chapel Hill, NC, 19University of Genoa, Genoa, Italy, 20Università Milano Bicocca, Milano, and IRCCS Fondazione San Gerardo dei Tintori, Monza, Italy

    Background/Purpose: Tofacitinib (TOF) has been shown to be efficacious in the treatment of polyarticular course JIA, including systemic JIA (sJIA) without active systemic features. Here…
  • Abstract Number: 0317 • ACR Convergence 2024

    Progressive Fibrosing Intersticial Lung Disease of Autoimmune Origin and Antifibrotic Medication: NEREA Registry

    Pablo Moreno-Fresneda1, Cristina Vadillo-Font2, Fredeswinda Romero-Bueno3, Olga Sánchez-Pernaute4, Rosalía Laporta5, hildegarda Godoy Tundidor6, Belén López-Muñiz7, Laura Cebrián7, Claudia Valenzuela8, Irene Llorente-Cubas9, Jesús Loarce10, Juan Rigual10, Benjamin fernandez-Gutierrez11, M Asuncion Nieto1 and lydia Abasolo Alcazar12, 1Hospital Clínico San Carlos, Madrid, Madrid, Spain, 2Hospital Clinico S Carlos, Madrid, Spain, 3Hospital Universitario Fundación Jiménez Díaz and IIS-FJD. Autonomous University of Madrid, Madrid, Spain, 4Department of Rheumatology and Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz and IIS-FJD. Autonomous University of Madrid, Madrid, Spain, 5Hospital Universitario Puerta de Hierro, Madrid, Spain, 6Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA , Madrid, Madrid, Spain, 7Hospital Universitario Infanta Leonor, Madrid, Spain, 8ILD Unit, Pulmonology Department, Hospital Universitario de la Princesa, University Autonomade Madrid, Madrid, Spain, Madrid, Madrid, Spain, 9Hospital Universitario de La Princesa, Madrid, Spain, 10Ramón y Cajal University Hospital, Madrid, Madrid, Spain, 11HOSPITAL CLINICO SAN CARLOS, Madrid, Spain, 12IdISSC. HCSC, Madrid, Spain

    Background/Purpose: Nintedanib and pirfenidone are approved therapies for the management of patients with progressive fibrosing interstitial lung diseases (ILD), including those of autoimmune origin (ILD…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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