Abstracts tagged "Disease-Modifying Antirheumatic Drugs (Dmards)"

Abstract Number: 0226 • ACR Convergence 2020
Similar Efficacy of Sarilumab Monotherapy (MONARCH) vs Sarilumab and Methotrexate Combination Therapy (MOBILITY B) in Patients with Rheumatoid Arthritis
Gerd Burmester¹, Vivian Bykerk², Maya Buch³, Yoshiya Tanaka⁴, Hideto Kameda⁵, Amy Praestgaard⁶, Hubert van Hoogstraten⁷, Antonio Fernandez-Nebro⁸ and Thomas Huizinga⁹, ¹Charité University Hospital Berlin, Berlin, Germany, ²Hospital for Special Surgery, New York, NY, ³Centre of Musculoskeletal Research, School of Biological Sciences, University of Manchester, Manchester, United Kingdom, ⁴The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ⁵Toho University, Tokyo, Japan, ⁶Sanofi, Cambridge, MA, ⁷Sanofi, Bridgewater, NJ, ⁸University of Malaga, Malaga, Spain, ⁹Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Sarilumab, as monotherapy or in combination with conventional synthetic DMARDs like methotrexate (MTX) has demonstrated improvement in symptomatic and functional outcomes in patients (pts)…
Abstract Number: 0504 • ACR Convergence 2020
Efficacy and Safety of Upadacitinib in Patients with Active Psoriatic Arthritis and Inadequate Response to Biologic Disease-Modifying Anti-Rheumatic Drugs: A Double-Blind, Randomized Controlled Phase 3 Trial
Mark Genovese¹, Apinya Lertratanakul², Jaclyn K Anderson², Kim Papp³, William Tillett⁴, Filip Van den Bosch⁵, Shigeyoshi Tsuji⁶, Eva Dokoupilova⁷, Mauro Keiserman⁸, Xin Wang², Sheng Zhong², Patrick Zueger², Aileen Pangan⁹ and Philip Mease¹⁰, ¹Stanford University Medical Center, Palo Alto, CA, ²AbbVie Inc., North Chicago, IL, ³Papp Clinical Research and Probity Medical Research, Waterloo, ON, Canada, ⁴Royal National Hospital for Rheumatic Diseases, Bath, UK; Department of Pharmacy and Pharmacology, University of Bath, Bath, UK, Bath, United Kingdom, ⁵Ghent University Hospital, Ghent, Belgium, ⁶Department of Orthopaedics/Rheumatology, National Hospital Organization, Osaka Minami Medical Center, Osaka, Japan, ⁷Uherske Hradiste and University of Veterinary and Pharmaceutical Sciences,, Brno, Czech Republic, ⁸Pontificial Catholic University, Porto Alegre, Brazil, ⁹Abbvie Inc., La Grange, IL, ¹⁰Seattle Rheumatology Associates, P.L.L.C., Seattle, WA
Background/Purpose: Upadacitinib (UPA) is an oral, reversible, JAK inhibitor approved for treatment of moderate to severe rheumatoid arthritis (RA) and currently under evaluation for treatment…
Abstract Number: 0817 • ACR Convergence 2020
Uptake of Janus Kinase Inhibitors for Management of Rheumatoid Arthritis in Australia
Geoffrey Littlejohn¹, Tegan Smith², Kathleen Tymms³, Peter Youssef⁴, Helen Cooley⁵, Sabina Ciciriello⁶, David Mathers⁷, Catherine OSullivan² and Hedley Griffiths⁸, ¹Monash Rheumatology, Clayton, VIC; OPAL Rheumatology Ltd, Sydney, NSW, Melbourne, Victoria, Australia, ²OPAL Rheumatology Ltd, Sydney, NSW, Kogarah, New South Wales, Australia, ³Canberra Rheumatology, Canberra, ACT, Canberra, Australian Capital Territory, Australia, ⁴University of Sydney, Sydney, NSW; Royal Prince Alfred Hospital, Camperdown, NSW, Camperdown, New South Wales, Australia, ⁵Hobart Private Hospital, Hobart, TAS, Taroona, Australia, ⁶Royal Melbourne Hospital, Melbourne, VIC, Melbourne, Victoria, Australia, ⁷Georgetown Rheumatology, Georgetown, NSW, Georgetown, New South Wales, Australia, ⁸Barwon Rheumatology Service, Geelong, VIC, Geelong, Victoria, Australia
Background/Purpose: JAK inhibitors (JAKi) are targeted synthetic DMARDs (tsDMARDs) with a different mode of action (MOA) to conventional synthetic and biologic DMARDs (cs and bDMARDs).…
Abstract Number: 1015 • ACR Convergence 2020
The Prevalence and Risk Factors for Liver Fibrosis Among Rheumatoid Arthritis (RA) Patients on Disease-Modifying Anti-rheumatic Drugs (DMARDs)
Chou Luan Tan¹, Boon Han Ng², Noor Shahrazat Ahmad², Shahrul Aiman Soelar², Muhammad Zulhilmi Asyraf Jazlan², Mohd Ammar Dzakirin Md Mansor², Mohd Azri Mohd Suan², Kuang Kiat Kiew², Zalwani Zainuddin², Muhammad Radzi Abu Hassan² and Chong Hong Lim², ¹Hospital Sultanah Bahiyah, Kementerian Kesihatan Malaysia, Alor Setar, Kedah, Malaysia, ²Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia
Background/Purpose: Majority of DMARDs, including methotrexate (MTX), leflunomide (LEF) and sulfasalazine (SSZ) arebelieved to be hepatotoxic, causing liver fibrosis. However, the clinical findings were inconsistent.…
Abstract Number: 1360 • ACR Convergence 2020
New-Onset Inflammatory Bowel Diseases Among IL-17 Inhibitors-Treated Patients: Results from the Case-Control MISSIL Study
Jean-Guillaume Letarouilly¹, Benjamin Pariente², Thao Pham³, Emilie Acquacalda⁴, Béatrice Banneville⁵, Sébastien Barbarot⁶, Elodie Bauer⁷, Pauline Baudart⁸, Pascal Claudepierre⁹, Arnaud Constantin¹⁰, Emmanuelle Dernis¹¹, Renaud Felten¹², Philippe Gaudin¹³, Céline Girard¹⁴, Bruno Gombert¹⁵, Philippe Goupille¹⁶, Xavier Guennoc¹⁷, Isabelle Henry-Desailly¹⁸, Denis Jullien¹⁹, Elena Karimova²⁰, Sylvain Lanot²¹, Loïc Le Dantec²², Tristan Pascart²³, Laurianne Plastaras²⁴, Nathalie Sultan-Bichat²⁵, Xavier Truchet²⁶, Stéphane Varin²⁷, Daniel Wendling²⁸, Lousie Gaboriau²⁹, Delphine Staumont-Sallé³⁰, Laurent Peyrin-Biroulet³¹ and René-Marc Flipo¹, ¹Univ-Lille, CHU Lille, department of rheumatology, Lille, France, ²Univ-Lille, CHU Lille, department of gastroenterology, Lille, France, ³Aix Marseille Univ, APHM, department of rheumatology, Marseille, France, ⁴CHPG, department of rheumatology, Monaco, Monaco, ⁵AP-HP, Hôpital Pitié-Salpêtrière, Service de Rhumatologie, Paris, 75013, Paris, France, ⁶CHU de Nantes, department of dermatology, Nantes, France, ⁷CHRU Nancy, department of rheumatology, VANDOEUVRE LES NANCY, Lorraine, France, ⁸CHU Caen, department of rheumatology, Caen, France, ⁹Hôpital Henri Mondor, Université Paris Est Créteil, EA 7379 EpiDermE, department of rheumatology, Créteil, France, ¹⁰Hospital Pierre Paul Riquet, Toulouse, France, ¹¹CH Le Mans, department of rheumatology, Le Mans, France, ¹²Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, France, ¹³CHU Grenoble, department of rheumatology, Grenoble, France, ¹⁴CHU Montpellier, department of rheumatology, Montpellier, France, ¹⁵CH La Rochelle, department of rheumatology, La Rochelle, France, ¹⁶CHU Tours, department of rheumatology, Tours, France, ¹⁷CH Saint-Brieuc, department of rheumatology, Saint-Brieuc, France, ¹⁸CHU Amiens, department of rheumatology, Amiens, France, ¹⁹CHU Lyon, department of dermatology, Lyon, France, ²⁰CH Lens, department of dermatology, Lens, France, ²¹CH Alençon, department of rheumatology, Alençon, France, ²²Ahnac, department of rheumatology, Hénin-Beaumont, France, ²³Ghicl, Hôpital Saint-Philibert, department of rheumatology, Lomme, France, ²⁴CH Colmar, department of gastroenterology, Colmar, France, ²⁵CH Ouest-Réunion, department of dermatology, Saint Paul, La Réunion, France, ²⁶HIA Sainte-Anne, department of gastroenterology, Toulon, France, ²⁷CHD Vendée, department of rheumatology, La Roche-sur-Yon, France, ²⁸CHU Besançon, department of rheumatology, Besancon, France, ²⁹Univ-Lille, CHU Lille, department of pharmacovigilance, Lille, France, ³⁰Univ-Lille, CHU Lille, department of dermatology, Lille, France, ³¹CHU Nancy, department of gastroenterology, VANDOEUVRE LES NANCY, Lorraine, France
Background/Purpose: A warning regarding safety of Interleukin 17 inhibitors (IL-17i) has been issued from data of randomized controlled trials (RCT) showing cases of new-onset inflammatory bowel…
Abstract Number: 1763 • ACR Convergence 2020
Blending Hierarchical Cluster Analysis and Cluster-Specific Regressions to Predict Clinical Outcome to Tofacitinib Treatment in Patients with Rheumatoid Arthritis
Robert Landewé¹, Daniel H Solomon², Gianluca Bonfanti³, Luigi Manca³, John C Woolcott⁴, Jasper Deuring⁵, Stephen Watt⁶, Pritha Bhadra Brown⁶, Rebecca Germino⁶, Birol Emir⁶ and Roger A Edwards⁷, ¹Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, ²Brigham and Women's Hospital, Boston, MA, ³Fair Dynamics Consulting, SRL, Milan, Italy, ⁴Pfizer Inc, Collegeville, PA, ⁵Pfizer Inc, Rotterdam, Netherlands, ⁶Pfizer Inc, New York, NY, ⁷Health Services Consulting Corporation, Boxborough, MA
Background/Purpose: Patients with RA exhibit wide variations in response to therapy. Early treatment response profiles may help us to better predict subsequent treatment response, thus…
Abstract Number: 0005 • ACR Convergence 2020
Geographical Variations in COVID-19 Perceptions and Patient Management: A National Survey of Rheumatologists
Bella Mehta¹, Deanna Jannat-Khah², Carol Mancuso³, Anne Bass¹, Carine Moezinia⁴, Allan Gibofsky³, Susan Goodman⁵ and Said Ibrahim⁶, ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ²Hospital for Special Surgery, New York City, NY, ³Hospital for Special Surgery, New York City, ⁴Hospital for Special Surgery, New York, ⁵Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁶Weill Cornell Medicine, Cleveland, OH
Background/Purpose: To investigate the perceptions and behaviors of rheumatologists in the United States (US) regarding the risk of COVID-19 for their autoimmune patients and the…
Abstract Number: 0229 • ACR Convergence 2020
Integrated Safety of Filgotinib in Patients with Moderately or Severely Active Rheumatoid Arthritis Receiving Treatment for up to 5.5 Years
Kevin Winthrop¹, Yoshiya Tanaka², Tsutomu Takeuchi³, Alan Kivitz⁴, Franziska Matzkies⁵, Mark Genovese⁵, Deyuan Jiang⁵, Kun Chen⁵, Beatrix Bartok⁵, Angelika Jahreis⁵, Robin Besuyen⁶, Gerd Burmester⁷ and Jacques-Eric Gottenberg⁸, ¹Oregon Health & Science University, Portland, OR, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ³Division of Rheumatology, Department of internal Medicine, School of Medicine, Keio University, Tokyo, Japan, ⁴Altoona Center for Clinical Research/Altoona Arthritis and Osteoporosis Center, Duncansville, PA, ⁵Gilead Sciences, Inc., Foster City, CA, ⁶Galapagos BV, Leiden, Netherlands, ⁷Charité University Hospital Berlin, Berlin, Germany, ⁸Strasbourg University Hospital, Strasbourg, France
Background/Purpose: The oral, selective Janus kinase-1 inhibitor filgotinib (FIL) significantly improved RA signs and symptoms in patients (pts) with MTX-naïve and MTX- and biologic-refractory RA.1–5…
Abstract Number: 0578 • ACR Convergence 2020
Going Digital Due to COVID 19 Crisis: A Rapid Reorganisation of Medication Clinics
Rian Penford¹, Angela Reith¹, Elaine Wren¹ and Kirsten Mackay¹, ¹Torbay and South Devon NHS Foundation Trust, Torquay, United Kingdom
Background/Purpose: Until the COVID 19 crisis we initiated DMARD(s) and Biologic therapies using shared medical clinics. More than 30 patients could seen per week, with…
Abstract Number: 0825 • ACR Convergence 2020
Sex Differences in the Efficacy and Safety of Tofacitinib in Rheumatoid Arthritis Patients: A Post Hoc Analysis of Phase 3 and Long-Term Extension Trials
Niall Jones¹, Vibeke Strand², Hendrik Schulze-Koops³, Eduardo Mysler⁴, Cassandra D Kinch⁵, David Gruben⁶, Rebecca Germino⁷, Carol A Connell⁶ and Lihi Eder⁸, ¹Division of Rheumatology, University of Alberta, Edmonton, AB, Canada, ²Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, ³Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, University of Munich, Munich, Germany, ⁴Organización Médica de Investigación, Buenos Aires, Argentina, ⁵Pfizer Canada ULC, Kirkland, QC, Canada, ⁶Pfizer Inc, Groton, CT, ⁷Pfizer Inc, New York, NY, ⁸Women’s College Research Institute, University of Toronto, Toronto, ON, Canada
Background/Purpose: Differences in efficacy outcomes favoring male vs female patients (pts) with RA have been reported with csDMARDs1 and TNF inhibitors;2 results with JAK inhibitors…
Abstract Number: 1034 • ACR Convergence 2020
Trend of Treatment Plans, and Outcomes of Therapy in Cardiac Sarcoidosis via Analysis of Standardized Uptake Values Score and Ejection Fraction Using a Cardiac PET-CT
Rabia Gill¹, Martin Lavellee¹, Michael Petrides¹, Sarah Ford¹, Gurukripa Kowlgi², Huzaefah Syed³ and Adam Sima³, ¹Virginia Commonwealth University, Richmond, VA, ²Mayo Clinic, Rochester, MN, ³VCU Health, Richmond, VA
Background/Purpose: Pharmacological management of cardiac sarcoidosis (CS) includes immunosuppressive therapy for active lesions, guideline-directed medical therapy for heart failure, and antiarrhythmics. Our goal was to observe the various…
Abstract Number: 1453 • ACR Convergence 2020
A First in Class Therapeutic Nanoparticle for Specific Targeting of Anti-citrullinated Protein Antibody Ameliorates Serum Transfer and Collagen Induced Arthritis
Sangita Khatri¹, Jonas Hansen¹, Mads Clausen¹, Tue Wenzel Kragstrup², Shu-Chen Hung³, Elizabeth Mellins⁴ and Kira Astakhova¹, ¹Technical University of Denmark, Copenhagen, Denmark, ²Aarhus University, Aarhus, Denmark, ³Amgen, Thousand Oaks, ⁴Stanford University, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is an immune mediated inflammatory disease with autoimmune features, including antibodies to citrullinated proteins and peptides (ACPAs). Several in vitro studies…
Abstract Number: 1764 • ACR Convergence 2020
Disease Modifying Anti-rheumatic Drug and Biologic Therapy in Pregnancy: A Single-center Mixed Methods Study
Lauren Glick¹, Justin Shamis², Taneisha McGhie³ and Dharini Mahendira⁴, ¹University of Toronto, Toronto, ON, Canada, ²North York General Hospital, Toronto, ON, Canada, ³Cornwall University Hospital, Kingston, Saint Andrew, Jamaica, ⁴University of Toronto - Toronto, Toronto, ON, Canada
Background/Purpose: Rheumatic diseases including rheumatoid arthritis, seronegative inflammatory arthritis and systemic lupus erythematosus can be associated with significant morbidity in women of child-bearing age. Both…
Abstract Number: 0007 • ACR Convergence 2020
Antimalarial Drug Shortages During the COVID-19 Pandemic: Results from the Global Rheumatology Alliance Patient Experience Survey
Emily Sirotich¹, Kevin Kennedy², Salman Surangiwala³, Teresa Semalulu¹, Maggie Larche¹, Jean Liew⁴, Zachary Wallace⁵, Philip Robinson⁶, Rebecca Grainger⁷, Jeffrey Sparks⁸, Julia Simard⁹, Jinoos Yazdany¹⁰, Monique Gore-Massy¹¹, Richard Howard¹², Mitchell Levine² and Jonathan Hausmann¹³, ¹McMaster University, Hamilton, ON, Canada, ²McMaster University, Hamilton, Canada, ³Queen’s School of Medicine, Kingston, Canada, ⁴University of Washington, Seattle, WA, ⁵Massachusetts General Hospital, Newton, MA, ⁶University of Queensland, Herston, Queensland, Australia, ⁷University of Otago, Wellington, New Zealand, ⁸Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ⁹Stanford Medicine, Stanford, CA, ¹⁰UCSF, San Francisco, CA, ¹¹Lupus Foundation of America, Brooklyn, NY, ¹²Spondylitis Association of America, Van Nuys, CA, ¹³Boston Children's Hospital / Beth Israel Deaconess Medical Center, Cambridge, MA
Background/Purpose: Early in the COVID-19 pandemic, hydroxychloroquine and chloroquine were empirically promoted and used for treatment and prevention of SARS-CoV-2 infection. The repurposing of these…
Abstract Number: 0232 • ACR Convergence 2020
Safety and Effectiveness of Tocilizumab in Patients with Renal Insufficiency in the Non-interventional Study ICHIBAN
Christof Specker¹, Martin Aringer², Gerd Burmester³, Johannes Gerlach⁴, Michael Hofmann⁵, Herbert Kellner⁶, Frank Moosig⁷, Hans-Peter Tony⁸ and Gerhard Fliedner⁹, ¹Clinic Essen-Mitte, Essen, Germany, ²Rheumatology, Medicine III, University Medical Center & Faculty of Medicine, TU Dresden, Dresden, Germany, Dresden, Germany, ³Charité University Hospital Berlin, Berlin, Germany, ⁴Roche Pharma AG, Grenzach-Wyhlen, Germany, ⁵Chugai, Frankfurt am Main, Germany, ⁶Rheumatology and Gastroenterology Specialty Practice, Munich, Germany, ⁷Rheumatology Center Schleswig-Holstein Middle, Neumünster, Germany, ⁸Rheumatology/Clinical Immunology, Department of Internal Medicine II, Würzburg, Germany, ⁹Rheumatology Practice, Onsabrück, Germany
Background/Purpose: RA increases a patient’s systemic inflammatory burden, which has been associated with development of chronic kidney disease (CKD), especially in patients with comorbid hypertension,…

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