Abstracts tagged "Disease Activity"

Abstract Number: 160 • 2016 ACR/ARHP Annual Meeting
Ultrasound Assessment of Rheumatoid Arthritis Patients. External Validation and Inter-Rater Reliability of a 4-Joint Ultrasonographic Scoring System
Tomas Cazenave¹, María Victoria Martire^2,3, Christian A. Waimann^4,5, Javier Rosa⁶, Marcelo Audisio⁷, Ana Bertoli⁸, Guillermo Py⁹, Santiago Ruta⁶, Josefina Marin¹⁰, Johana Zacariaz⁶, Cristian Troitiño¹¹, Mariana Benegas¹², Lida Santiago¹³, Patricio Tate¹⁴, Walter J. Spindler¹⁵, Horacio Berman¹⁶, María Julia Santa Cruz¹⁷, Paula Kohan¹⁸, Silvia Beatriz Papasidero¹⁹, Gustavo Citera²⁰ and Marcos G. Rosemffet¹, ¹Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ²Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ³Rheumatology, Hospital Italiano de La Plata, La Plata, Argentina, ⁴Escuela Superior de Ciencias de la Salud, UNICEN., Olavarria,, Argentina, ⁵Rheumatology, Hospital Dr. Hector Cura, Olavarria, Argentina, ⁶Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ⁷Servicio de Reumatología del Hospital Nacional de Clínicas, Córdoba, Argentina, ⁸Instituto Reumatológico Strusberg, Córdoba, Argentina, ⁹Servicio de Reumatología del Hospital Nacional de Clínicas, Córdoba., Cordoba, Argentina, ¹⁰Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ¹¹Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, ¹²PSORIAHUE, Buenos Aires, Argentina, ¹³Organizacion Medica de Investigacion, Buenos Aires, Argentina, ¹⁴Organizacion Médica de Investigación, Buenos Aires, Argentina, ¹⁵Centro Médico Privado de Reumatología, Tucuman, Argentina, ¹⁶Centro Médico Privado de Reumatología, Tucumán, Argentina, ¹⁷Hospital Dr. E. Tornú, Buenos Aires, Argentina, ¹⁸Hospital Dr. E. Tornu, Buenos Aires, Argentina, ¹⁹Rheumatology Department, Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ²⁰Rheumatology Section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina
Background/Purpose: Although Ultrasound (US) has demonstrated to be a sensitive and specific tool, its feasibility in daily clinical practice is still under debate. We have…
Abstract Number: 2 • 2015 ACR/ARHP Annual Meeting
The Neutrophil Protein S100A12 Has Stronger Associations with a Comprehensive Ultrasound Score of Synovitis Than Vascular Endothelial Growth Factor in a Longitudinal Study of Rheumatoid Arthritis Patients
Hilde Haugedal Nordal^1,2 and Hilde Berner Hammer³, ¹Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ²Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: S100A12, a neutrophil protein, has proinflammatory effects on immune cells and can activate endothelial cells. The mechanism of action suggests vascular endothelial growth factor…
Abstract Number: 171 • 2015 ACR/ARHP Annual Meeting
Serum Calprotectin Levels Correlate with Ultrasonographic Synovitis in Rheumatoid Arthritis Patients
Jana Hurnakova¹, Jakub Zavada¹, Petra Hanova¹, Hana Hulejová¹, Martin Klein¹, Herman F Mann¹, Olga Sleglova¹, Marta Olejarova¹, Šárka Forejtová¹, Olga Ruzickova¹, Martin Komarc², Jiri Vencovsky¹, Karel Pavelka¹ and Ladislav Senolt¹, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Institute of Biophysics and Informatics of the First Faculty of Medicine, Charles University, Prague, Czech Republic
Background/Purpose: Calprotectin (S100A8/9, MRP8/14) has been demonstrated as a promising biomarker of clinical and laboratory disease activity in rheumatoid arthritis (RA). In addition, two small…
Abstract Number: 535 • 2015 ACR/ARHP Annual Meeting
Taurine As a Biomarker for Prediction of Response to Biologic Therapy in Rheumatoid Arthritis
Soshi Takahashi¹, Jun Saegusa², Ikuko Naka¹, Kosaku Tsuda¹, Takaichi Okano¹, Kengo Akashi¹, Miwa Nishida¹, Keisuke Nishimura², Sho Sendo², Yo Ueda¹, Akira Onishi³, Yoshinori Kogata², Goichi Kageyama² and Akio Morinobu², ¹Department of Rheumatology, Kobe University Hospital, Kobe, Japan, ²Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Rheumaology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: To identify a serum biomarker for prediction of the response to biologics (Bio) in patients with rheumatoid arthritis (RA), we performed serum metabolomics analysis…
Abstract Number: 757 • 2015 ACR/ARHP Annual Meeting
The Ratio Between TNF-a and P-Albumin – a Suggested Measure of Disease Activity in SLE
Susanna Eketjäll¹, Helena Idborg², Johanna Gustafsson³, Agneta Zickert², Marika Kvarnstrom⁴, Vilija Oke⁵, Susanne Pettersson⁴, Per Johan Jakobsson⁴, Iva Gunnarsson⁴ and Elisabet Svenungsson⁴, ¹Department of Clinical Neuroscience, Karolinska Institutet, Solna, AstraZeneca Translational Sciences Centre, Science for Life Laboratory, Personal Healthcare and Biomarkers, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁴Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁵Department of medicine, Unit of Rheumatology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: There is presently no consensus on how to best measure disease activity in systemic lupus erythematosus (SLE). Available validated measures, such as SLE Disease…
Abstract Number: 1560 • 2015 ACR/ARHP Annual Meeting
The Effect of Anti Estrogen Therapy (AET) on Rheumatoid Arthritis
Bassam Alhaddad¹, Amrita Kaur Bath², Bassem Zraik³, Mohamed Alalwani⁴ and Stanley P Ballou¹, ¹Rheumatology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, ²Internal medicine, Fairview Hospital- Cleveland Cinic, Cleveland, OH, ³Internal Medicine, Fairview Hospital- Cleveland Clinic, cleveland, OH, ⁴Hospital Medicine, Cleveland Clinic, Cleveland, OH
Background/Purpose: The well-known positive effect of pregnancy on improving Rheumatoid Arthritis (RA) disease activity suggests that hormonal changes may play a role in disease pathogenesis…
Abstract Number: 2277 • 2015 ACR/ARHP Annual Meeting
Working Harder to Stay in Control: Patient Reports of Flare in Early RA Are Associated with Higher Disease Activity and More Intensive Self Management
Susan J. Bartlett^1,2, Clifton O. Bingham III³, Daming Lin⁴, Kathleen Andersen⁵, Gilles Boire⁶, Carol Hitchon⁷, Boulos Haraoui⁸, Edward C. Keystone⁹, Diane Tin¹⁰, J Carter Thorne¹¹, Janet E. Pope¹², VP Bykerk⁴ and CATCH Investigators and OMERACT Flare Group, ¹Clinical Epidemiology, McGill University, Montreal, QC, Canada, ²Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, ³Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Hospital for Special Surgery, New York, NY, ⁶Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁷Department of Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁸Institut de Rhumatologie, Montreal, QC, Canada, ⁹Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ¹⁰The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹¹University of Toronto, Toronto, ON, Canada, ¹²University of Western Ontario, London, ON, Canada
Background/Purpose: Early rheumatoid arthritis (ERA) patients attending office visits often report being in a disease flares. We evaluated patient reports of flare in relation to…
Abstract Number: 2589 • 2015 ACR/ARHP Annual Meeting
Associations Between 49 Susceptibility SNPs and Disease Activity Including Radiographic Damage in Early Untreated Rheumatoid Arthritis
Christian G. Ammitzbøll¹, Rudi Steffensen², Martin Bøgsted^3,4, Kaspar Rene Nielsen², Torkell Ellingsen⁵, Merete Lund Hetland⁶, Peter Junker⁵, Jan Pødenphant⁷, Mikkel Østergaard⁸, Julia Johansen⁹, Kim Hørslev-Petersen¹⁰ and Kristian Stengaard-Pedersen¹, ¹Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ²Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, ³Department of Haematology, Aalborg University Hospital, Aalborg, Denmark, ⁴Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark, Aalborg, Denmark, ⁵Department of Rheumatology, Odense University Hospital, Odense, Denmark, ⁶DANBIO, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Glostrup, Denmark, ⁷Department of Rheumatology, Copenhagen University Hospital at Gentofte, Glostrup, Denmark, ⁸Rigshospitalet-Glostrup, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, Glostrup, Denmark, ⁹Departments of Medicine and Oncology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark, ¹⁰Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Graasten, Denmark
Background/Purpose: Genome-wide association studies (GWAS) and meta-GWAS studies have identified >50 single nucleotide-polymorphisms (SNPs) that are associated with susceptibility to rheumatoid arthritis (RA). It is,…
Abstract Number: 2675 • 2015 ACR/ARHP Annual Meeting
Has the Relationship Between Disease Activity and Disability in Rheumatoid Arthritis Changed?
Aneela Mian¹, Fowzia Ibrahim^2,3, Ian C. Scott⁴, Sardar Bahadur⁵, Maria Filkova⁶, Louise Pollard⁷, Gabrielle H. Kingsley⁸, Sophia Steer⁹, David L. Scott⁶ and James Galloway¹⁰, ¹Academic Rheumatology, King's College London, London, United Kingdom, ²Academic Rheumatology Dept, King's College, London, United Kingdom, ³Academic Rheumatology Dept, King's College London, London, United Kingdom, ⁴Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ⁵Guys' and St Thomas' NHS Trust, London, United Kingdom, ⁶Academic Department of Rheumatology, King´s College London, London, United Kingdom, ⁷University Hospital Lewisham, London, United Kingdom, ⁸Rheumatology, Kings College London, London, United Kingdom, ⁹Rheumatology Dept, Kings College Hospital, London, United Kingdom, ¹⁰King's College Hospital, London, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) management paradigms have changed over the last two decades. Evidence now supports aggressive immunosuppression with early use of combination disease modifying…
Abstract Number: 3080 • 2015 ACR/ARHP Annual Meeting
Histone H2AX Phosphorylation As a Measure of DNA Double Strand Breaks and a Marker of Environmental Stress and Disease Activity in Lupus
Rajaie Namas, Paul Renauer, Mikhail Ognenovski, Pei-Suen Tsou and Amr H. Sawalha, Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Studies suggested that defective or inefficient DNA double strand break (DSB) repair results in failure to preserve genomic integrity leading to apoptotic cell death,…
Abstract Number: 46 • 2015 ACR/ARHP Annual Meeting
Feasibility Study of Smartphone Data Collection for Cloudy with a Chance of Pain: Sustained Engagement for Daily Self-Reporting of Disease Severity in Rheumatoid Arthritis over Two Months
Samuel Reade¹, Jamie C Sergeant^2,3, Matthew Sperrin⁴, David M. Schultz⁵, Karen Spencer⁶, Caroline Sanders⁶ and William G Dixon⁷, ¹The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, ⁴Institute of Population Health, Health e-Research Centre, The University of Manchester, Manchester, United Kingdom, ⁵Faculty of Engineering and Physical Sciences, School of Earth, Atmospheric and Environmental Sciences, The University of Manchester, Manchester, United Kingdom, ⁶Institute of Population Health, Centre for Primary Care, The University of Manchester, Manchester, United Kingdom, ⁷Manchester Academic Health Sciences Centre, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Previous research has attempted to study the association between weather and joint pain. Inconclusive results may be due, in part, to infrequent measures of…
Abstract Number: 172 • 2015 ACR/ARHP Annual Meeting
Prospective Assessment of Carotid Intima Media Thickness in Relation to Activity of the Disease in Patients with Rheumatoid Arthritis
Bozena Targonska-Stepniak¹, Mariusz Piotrowski¹, Robert Zwolak² and Maria Majdan³, ¹Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Poland, Lublin, Poland, ²Rheumatologyand Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland, ³Department of Rheumatology and Connective Tissue Diseases, Medical University in Lublin, Poland, Lublin, Poland
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, inflammatory disease that is complicated by accelerated atherosclerosis associated with the risk of adverse cardiovascular (CV) events and…
Abstract Number: 541 • 2015 ACR/ARHP Annual Meeting
Microrna-125b Expression in PBMCs Is Associated with Disease Activity in Patients with Early Rheumatoid Arthritis
Veronika Hruskova^1,2, Romana Jandová³, Lucia Vernerova⁴, Herman F Mann⁵, Klára Prajzlerová⁴, Maria Filkova⁴, Karel Pavelka⁵, Jiri Vencovsky⁵ and Ladislav Senolt⁵, ¹Institute of Rheumatology and Department of Rheumatology; Faculty of Science Charles University, Prague, Czech Republic, ²Faculty of Science, Charles University, Prague, Czech Republic, ³Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, ⁴Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: MicroRNAs (miRNAs) are small non-coding RNAs that function as negative regulators of gene expression at posttranscription level and play a significant role in rheumatoid…
Abstract Number: 771 • 2015 ACR/ARHP Annual Meeting
Convergent Validity of New Disease Assessment Instruments in Systemic Lupus Erythematosus in Relation to Sledai-2K
Christopher Collins¹, W. Winn Chatham², Howard Busch³, Norman B. Gaylis⁴, Emily Hautamaki⁵ and Siva Narayanan⁶, ¹MedStar Washington Hospital Center, Washington, DC, ²Medicine/Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Science & Research Institute, Jupiter, FL, ⁴Arthritis & Rheumatic Disease Specialties, Aventura, FL, ⁵Ipsos Healthcare, Washington, DC, ⁶Global Evidence, Value and Access, Ipsos Healthcare, Washington, DC
Background/Purpose: Current validated disease assessment instruments (DAIs) in systemic lupus erythematosus (SLE) such as SLEDAI-2K and BILAG, require disease expertise and/or involve complex scoring systems,…
Abstract Number: 1579 • 2015 ACR/ARHP Annual Meeting
Association of Myocardial Abnormalities with N-Terminal Pro-Brain Natriuretic Peptide and Disease Activity in Rheumatoid Arthritis without Cardiac Symptoms, Assessed By Cardiac Magnetic Resonance Imaging
Hitomi Kobayashi¹, Yasuyuki Kobayashi², Isamu Yokoe³, Natsumi Ikumi^4,5, Hirotake Inomata⁶, Atsuma Nishiwaki⁶, Noboru Kitamura¹, Kaita Sugiyama⁶, Hidetake Shiraiwa⁶, Masataka Nozaki⁶, Yosuke Nagasawa⁶, Yoshihiro Matsukawa⁵ and Masami Takei¹, ¹Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ²Advanced Biomedical Imaging Informatics, St.Marianna University School of Medicine, Kawasaki, Japan, ³Rheumatology, Itabashi Chuo Medical Center, Tokyo, Japan, ⁴Nihon University School of Medicine, Shinjuku, Japan, ⁵Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ⁶Nihon University School of Medicine, Tokyo, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a multi-organ inflammatory disorder associated with high cardiovascular morbidity and mortality. Cardiac involvements are typically clinically silent, only manifesting as…

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