Abstracts tagged "Disease Activity"

Abstract Number: 3083 • 2016 ACR/ARHP Annual Meeting
Utility of Patient-Reported Outcomes Measurement Information System (PROMIS) 29 Short Form for Understanding Interplay Between Patient-Reported Outcome Measures and Physician Driven Disease Activity Measures
Yong Gil Hwang¹, Juan (June) Feng², Heather Eng², Jason Lyons², Anthony Fabio² and Larry W. Moreland¹, ¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, PA
Background/Purpose: Discordance between patient and physician assessment of rheumatoid arthritis (RA) disease activity strongly associates with pain scores. Patient-reported outcomes measurement information system (PROMIS) 29…
Abstract Number: 115 • 2016 ACR/ARHP Annual Meeting
Early Inflammatory Arthritis Presentation, Management and Outcomes in Canadian Aboriginal Patients
Sujay Nagaraj¹, Cheryl Barnabe², Orit Schieir³, Vivian P. Bykerk⁴, Janet Pope⁵, Shahin Jamal⁶, Gilles Boire⁷, Edward Keystone⁸, Diane Tin⁹, Boulos Haraoui¹⁰, J Carter Thorne¹¹, Carol Hitchon¹² and Canadian Early Arthritis Cohort (CATCH) Investigators, ¹McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada, ²Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ³Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁴Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ⁵University of Western Ontario, St Joseph's Health Care, London, ON, Canada, ⁶University of British Columbia, Vancouver, BC, Canada, ⁷Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, ⁸Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁹The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹⁰Institute de Rheumatologie, Montreal, QC, Canada, ¹¹Southlake Regional Health Centre, Newmarket, ON, Canada, ¹²University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Differences in access to care that influence the timing and quality of treatment interventions may create outcome inequities for Aboriginal patients with inflammatory arthritis.…
Abstract Number: 522 • 2016 ACR/ARHP Annual Meeting
Patient-Provider Discordance in Global Assessments of Disease Activity in Patients with Rheumatoid Arthritis: Persistence, Predictors and Impact
Divya N.V Challa¹, Zoran Kvrgic¹, Cynthia S. Crowson², Daniel Schaffer¹, Thomas G. Mason II³, Scott T. Persellin⁴, Clement Michet Jr.¹, Theresa L. Wampler Muskardin¹, Kerry Wright¹, Eric L. Matteson¹ and John M. Davis III⁵, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN, ³Division of Rheumatology - Department of Medicine, Mayo Clinic Rochester, Rochester, MN, ⁴Department of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Patient-provider discordance in global assessment (GA) of disease activity is a potential threat to patient-centered management of individuals with RA. The estimated prevalence of…
Abstract Number: 786 • 2016 ACR/ARHP Annual Meeting
Complement Split Product iC3b and C3 Blood Levels Best Associate with Active and Clinically Meaningful Changes in SLE Disease Activity
Alfred Kim¹, Deepali Sen², Vibeke Strand³, Qiang John Fu⁴, Nancy Mathis¹, Robin Bruchas⁵, Nick Staten⁵, Martin Schmidt⁶, Paul Olson⁵, Chad Stiening⁵ and John Atkinson¹, ¹Rheumatology, Washington University School of Medicine, Saint Louis, MO, ²Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, ³Stanford University School of Medicine, Palo Alto, CA, ⁴Biostatistics, Saint Louis University, Saint Louis, MO, ⁵Kypha, Inc., Saint Louis, MO, ⁶Kypha, Inc., St. Louis, MO
Background/Purpose: A major unmet need in SLE is the identification of a biomarker that consistently tracks with disease activity. One current approach is measuring complement…
Abstract Number: 1331 • 2016 ACR/ARHP Annual Meeting
Disease Patterns and Long Term Outcome Amongst Patients with Relapsing Polychondritis – Single Centre Experience
Chee Ken Cheah, Shirish Sangle (Joint First Author) and David D'Cruz, Louise Coote Lupus Unit, Guy's and St. Thomas' Hospital, London, United Kingdom
Background/Purpose: Relapsing polychondritis (RP) is a rare autoimmune disorder characterized by cartilage inflammation and damage. Chronic RP may lead to sequelae due to cartilage tissue…
Abstract Number: 1522 • 2016 ACR/ARHP Annual Meeting
Disease Burden in Rheumatoid Arthritis (RA) Patients Who Have Secondary Osteoarthritis (OA) Is Lower Than in OA but Higher Than in RA with No Secondary OA
Isabel Castrejón¹, Anne-Marie Malfait², Joel Block³ and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL, ³Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Recent data indicate that the disease burden experienced by patients with osteoarthritis (OA) is similar to or greater than in rheumatoid arthritis (RA) (EULAR…
Abstract Number: 1757 • 2016 ACR/ARHP Annual Meeting
Association of the Lupus Low Disease Activity State (LLDAS) with Health-Related Quality of Life
Vera Golder¹, Rangi Kandane-Rathnayake², Alberta Y. Hoi³, Molla Huq⁴, Worawit Louthrenoo⁵, Yuan An⁶, Zhanguo Li⁶, Shue Fen Luo⁷, Sargunan Sockalingam⁸, Chak Sing Lau⁹, Mo Yin Mok¹⁰, Aisha Lateef¹¹, Kate Franklyn³, Susan Morton¹², Sandra V. Navarra¹³, Leonid Zamora¹³, Yeong-Jian Wu⁷, Laniyati Hamijoyo¹⁴, Madelynn Chan¹⁵, Sean O'Neill¹⁶, Fiona Goldblatt¹⁷, Mandana Nikpour¹⁸, Eric F Morand³ and Asia Pacific Lupus Collaboration, ¹Southern Clinical School, Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ²Rheumatology, Monash University, Melbourne, Australia, ³Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ⁴Department of Medicine (Rheumatology), Melbourne University, Melbourne, Australia, ⁵Division of Rheumatology, Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand, ⁶Peking University People's Hospital, Beijing, China, ⁷Chang Gung University, Taoyuan County, Taiwan, ⁸University of Malaya, Kuala Lumpur, Malaysia, ⁹Univ Dept of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, ¹⁰Queen Mary Hospital, Hong Kong, Hong Kong, ¹¹Medicine/Rheumatology, National University Health System, Singapore, Singapore, ¹²Monash Health, Melbourne, Australia, ¹³Rheumatology, University of Santo Tomas Hospital, Manila, Philippines, ¹⁴University of Padjadjaran, Bandung, Indonesia, ¹⁵Tan Tock Seng Hospital, Singapore, Singapore, ¹⁶University of New South Wales, Sydney, Australia, ¹⁷Royal Adelaide Hospital, Adelaide, Australia, ¹⁸Melbourne University, Melbourne, Australia
Background/Purpose: Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a Lupus Low Disease…
Abstract Number: 2230 • 2016 ACR/ARHP Annual Meeting
Models Using Claims-Based Administrative Data Are Poor Predictors of Rheumatoid Arthritis Disease Activity in VA Rheumatoid Arthritis (VARA) Patients
Brian Sauer¹, Chia-Chen Teng², Neil Accortt³, Zachary Burningham⁴, David Collier⁵, Mona Trivedi⁶ and Grant W. Cannon⁷, ¹IDEAS Center and Division of Epidemiology, HSR&D SLC VA Medical Center and University of Utah, Salt Lake City, UT, ²Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ³Center for Observational Research, Amgen, Inc., C, CA, ⁴SLC Veterans Affairs Medical Center, SLC IDEAS Center, Salt Lake City, UT, ⁵Amgen Inc., Thousand Oaks, CA, ⁶Amgen, Thousand Oaks, CA, ⁷Internal Medicine, Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT
Background/Purpose: The goal of this study was to validate a claims-based statistical model to predict disease activity measured by the 28-joint count Disease Activity Score…
Abstract Number: 2603 • 2016 ACR/ARHP Annual Meeting
Real World Practice Based Clinical Study of Delayed-Release Prednisone Produces Comparable Results to a Controlled Clinical Trial: Morning Stiffness and Disease Measures in Moderate-Severe RA Patients Switched from Immediate-Release to Delayed Release-Prednisone
Ara H. Dikranian¹, Rubaiya Mallay², Mike Marshall³, Megan Francis-Sedlak³ and Robert J. Holt^4,5, ¹San Diego Arthritis Medical Clinic, San Diego, CA, ²Suncoast Internal Medicine Consultants and Largo Med Center, Largo, FL, ³Horizon Pharma USA, Inc, Lake Forest, IL, ⁴Medical Affairs, Horizon Pharma, Inc, Lake Forest, IL, ⁵College of Pharmacy, University of Illinois-Chicago, Vernon Hill, IL
Background/Purpose: Patients with RA have previously demonstrated significant differences in morning stiffness (MS), a debilitating symptom of RA, and other disease measures with delayed release…
Abstract Number: 2818 • 2016 ACR/ARHP Annual Meeting
High Sensitivity Multiplex ELISA Reveals Cytokine Expression Heterogeneity in Active SLE
John A. Reynolds¹, Sahena Haque², Eoghan M. McCarthy³, Jamie C Sergeant⁴, Elaine Lee⁵, Eileen Holling Lee⁵, Steven Kilfeather⁵, Benjamin Parker⁶ and Ian N. Bruce⁷, ¹NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ²Rheumatology department, University Hospitals of South Manchester NHS Foundation Trust, Manchester, United Kingdom, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospital NHS Foundation Trust, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK, Manchester, United Kingdom, ⁵Aeirtec Limited, UK, North Shields, United Kingdom, ⁶Centre for Musculoskeletal Research, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁷Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom
Background/Purpose: Patients with SLE have a broad clinical and immunological phenotype in which multiple immune pathways may be sequentially or simultaneously activated. No reliable biomarkers…
Abstract Number: 3087 • 2016 ACR/ARHP Annual Meeting
Association of Weight Loss with Improved Disease Activity in Patients with Rheumatoid Arthritis
David J. Kreps^1,2, Florencia Halperin³, Sonali P. Desai³, Zhi Zhang³, Elena Losina³, Elizabeth W. Karlson¹, Bonnie L. Bermas¹ and Jeffrey A. Sparks⁴, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Boston University, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose : Obesity has been associated with worsened RA outcomes and increased disease activity. However, few longitudinal studies have investigated whether weight loss might improve…
Abstract Number: 136 • 2016 ACR/ARHP Annual Meeting
The 7-Joints Musculoskeletal Ultrasound Score (US7 score) Predicts Therapeutic Change in Patients with Early Rheumatoid Arthritis
Sarah Ohrndorf¹, Philipp Daniel Oberdorfer², Lien Le³, Ulrich Mansmann³, Lisa Ines Sprenger², Thomas Häupl⁴, Sandra Hermann², Gabriela Schmittat², Silvia Pade², GR Burmester⁵, Anne-Marie Glimm² and Marina Backhaus⁶, ¹Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, ³Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität Munich, Munich, Germany, ⁴Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁵Charité – University Medicine Berlin, Berlin, Germany, ⁶Department of Rheumatology & Immunology, University Medicine Charit, Berlin, Germany
Background/Purpose: Treatment decisions in patients with Rheumatoid Arthritis (RA) after the “Treat to Target (T2T)” - principle is widely recommended, as this management strategy leads…
Abstract Number: 527 • 2016 ACR/ARHP Annual Meeting
The Summed Bilateral Elbow Extension Angle in Rheumatoid Arthritis Correlates with the DAS28-CRP(4) and May be an Independent Marker of Bad Prognosis
John P. Case¹, Congbin Wang² and Heidi Tucker³, ¹Internal Medicine/Rheumatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, ²Internal medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, ³Rush Medical College, Chicago, IL
Background/Purpose: The elbow is an easily-examined joint and an important determinant of morbidity in rheumatoid arthritis (RA). In active RA the measured elbow extension angle,…
Abstract Number: 787 • 2016 ACR/ARHP Annual Meeting
Using the American College of Rheumatology and Systemic Lupus International Collaborating Clinics Criteria to Measure Disease Severity in Discoid Lupus Erythematosus
Jenna K. Presto^1,2, Jessica S. Haber^1,2 and Victoria P. Werth^1,2, ¹Department of Dermatology, University of Pennsylvania, Philadelphia, PA, ²Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
Background/Purpose: Discoid lupus erythematosus (DLE) progresses to systemic lupus erythematosus (SLE) in up to 28% of cases. The Systemic Lupus International Collaborating Clinics (SLICC) SLE…
Abstract Number: 1361 • 2016 ACR/ARHP Annual Meeting
The Role of Von Willebrand Factor Antigen As a Disease Biomarker in the Clinical Assessment of Children with Juvenile Dermatomyositis
Dawn Wahezi¹, Vito Arena², Jaeun Choi² and Qi Gao², ¹Pediatric Rheumatology, The Children's Hospital at Montefiore, Bronx, NY, ²Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: With the advent of new therapies, outcomes for children with juvenile dermatomyositis (JDM) have significantly improved. Accurate markers of clinically inactivedisease are thus fundamental…

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