Abstracts tagged "Disease Activity"

Abstract Number: 185 • 2016 ACR/ARHP Annual Meeting
The Interferon Gene Signature Is Increased in Early DMARD Naive Rheumatoid Arthritis and Predicts a Poorer Response to Initial Therapy
Faye A H Cooles¹, Amy E. Anderson¹, Dennis W Lendrem¹, Julie Norris¹, Arthur G. Pratt¹, Catharien M U Hilkens² and John D Isaacs³, ¹Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ²Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom, ³Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom
Background/Purpose: Type 1 interferons, such as interferon-α, are of increasing interest in autoimmunity due to their pleiotropic effects on the immune system. Approximately 20-30% of…
Abstract Number: 551 • 2016 ACR/ARHP Annual Meeting
Changes in Diverse Disease Activity Measures Are Highly Correlated Following the Initiation of Most Treatment Modalities in the Management of Longstanding Rheumatoid Arthritis
Craig Wiesenhutter, Coeur d'Alene Arthritis Clinic, Coeur D Alene, ID; University of Washington School of Family Medicine, Seattle, ID
Background/Purpose: Treating rheumatoid arthritis (RA) patients to target (T2T) has been shown to result in better outcomes in patients with relatively recent onset RA. The…
Abstract Number: 899 • 2016 ACR/ARHP Annual Meeting
Disparities in Disease Characteristics, Treatment Pattern and Comorbidities in 1,858 Patients with Polymyalgia Rheumatica, Giant Cell Arteritis or Both Diseases
Dörte Huscher¹, Katinka Albrecht¹, Frank Buttgereit², Martin Aringer³, Guido Hoese⁴, Wolfgang Ochs⁵, Katja Thiele¹ and Angela Zink^1,2, ¹Epidemiology, German Rheumatism Research Centre, Berlin, Germany, ²Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ³Medicine III, University Medical Center and Faculty of Medicine at the TU Dresden, Dresden, Germany, ⁴Rheumatologische Fachpraxis Stadthagen, Stadthagen, Germany, ⁵Internistisch-rheumatologische Praxisgemeinschaft Bayreuth, Bayreuth, Germany
Background/Purpose: Methods: Conclusion:
Abstract Number: 1374 • 2016 ACR/ARHP Annual Meeting
Predictors of Changes in Disease Activity Among Children with Juvenile Dermatomyositis
Cynthia S. Crowson¹, Jeannette M. Olazagasti Lourido², Timothy B. Niewold³, Ann M Reed⁴ and CARRA Investigators, ¹Health Sciences Research, Mayo Clinic, Rochester, MN, ²University of Puerto Rico, San Juan, Puerto Rico, ³Rheumatology and Immunology, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Duke University, Durham, NC
Background/Purpose: Determinants of changes in disease activity among patients with juvenile dermatomyositis (JDM) are unknown. Our objective was to develop scores to predict changes in…
Abstract Number: 1548 • 2016 ACR/ARHP Annual Meeting
Correlates of Fatigue in People Living with Rheumatoid Arthritis
Jet Veldhuijzen van Zanten^1,2, Sally Fenton^3,4, Peter Rouse⁵, George Metsios^3,6, Ahmad Osailan^1,2, Chen-an Yu², Nikos Ntoumanis⁷, Joan Duda⁴ and George Kitas^1,2, ¹Department of Rheumatology, Dudley Group NHS Foundation Trust, Dudley, United Kingdom, ²School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom, ³Department of Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, ⁴School of Sport, Exercise and Rehabilitation, University of Birmingham, Birmingham, United Kingdom, ⁵Department for Health, University of Bath, Bath, United Kingdom, ⁶Department of Physical Activity Exercise and Health, University of Wolverhampton, Walsall, United Kingdom, ⁷School of Psychology & Speech Pathology, Curtin University, Perth, Australia
Background/Purpose: Fatigue is a frequently mentioned symptom by people living with rheumatoid arthritis (RA). However, little research has explored the associations between fatigue and other…
Abstract Number: 1831 • 2016 ACR/ARHP Annual Meeting
A Novel Graph Theoretic Approach Applied to Modular Repertoire Analysis Identifies a Dual Molecular Progression in Adult SLE Patients, with Distinct Interferon and Neutrophil Transcription Patterns
Ilya Korsunski¹, Noémie Jourde-Chiche^2,3, Peter K. Gregersen¹, Damien Chaussabel⁴, Laurent Chiche⁵ and Naomi I Maria⁶, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Vascular Research Center of Marseille, Aix-Marseille Univ., Vascular Research Center of Marseille, Marseille, France, ³Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, ⁴Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, ⁵internal medicine, Hopital Europeen, Marseille, France, ⁶Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Gene expression studies support a pivotal role for type I interferon (IFN) in SLE. Previous work using a modular repertoire analysis based on co-clustered…
Abstract Number: 2468 • 2016 ACR/ARHP Annual Meeting
Assessment of the American-English Version of the French FLARE in Rheumatoid Arthritis
Nashla Barroso¹, Thasia G Woodworth², Francis Guillemin³, Daniel E. Furst⁴, Jenny Brook⁵, Suzanne Kafaja⁶, David Elashoff⁵, Bruno Fautrel⁷ and Veena Ranganath⁸, ¹Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Leading Edge Clinical Research, Stuart, FL, ³CHRU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, ⁴David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁵Medicine, David Geffen School of Medicine, Los Angeles, CA, ⁶Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁷Rheumatology, Pitié Salpêtrière Hospital, Paris, France, ⁸Cumberland Valley Rheumatology, P.C., Chambersburg, PA
Background/Purpose: Due to the lack of consensus of the definition of a rheumatoid arthritis (RA) flare, the French “FLARE” (FLare Assessment in RA) instrument was…
Abstract Number: 2705 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Autophagy Genes and Their Association with Spinal Damage in Patients with Ankylosing Spondylitis
Min-Chan Park¹, Hye Won Kim², Jason Jungsik Song¹ and Yong-Beom Park¹, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: However, a role of autophagy in ankylosing spondylitis has not been clearly elucidated and the association of autophagy-related gene expression levels with inflammatory or…
Abstract Number: 2847 • 2016 ACR/ARHP Annual Meeting
Antibodies to Double Stranded DNA: Combined Standard ELISA and High-Salt ELISA Assays for the Detection of SLE Disease Activity
Laura Durcan, Jenna Thomason, Daniel Kuo and Mark H. Wener, University of Washington, Seattle, WA
Background/Purpose: Serological markers in systemic lupus erythematosus (SLE) are crucial objective measures included in disease activity indices. Antibodies to double stranded DNA (anti-dsDNA) are included…
Abstract Number: 3192 • 2016 ACR/ARHP Annual Meeting
Influence of Temperature and Humidity on Disease Activity in Rheumatoid Arthritis
Peter Mandl¹, Farideh Alasti¹, Rainer Kaltenberger², Thomas Krennert², Gabriela Supp¹, Uriel Landesmann¹, Josef S. Smolen³ and Daniel Aletaha⁴, ¹Department of Internal Medicine III; Division of Rheumatology, Medical University Vienna, Vienna, Austria, ²Central Institute for Meteorology and Geodynamics, Vienna, Austria, ³Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria
Background/Purpose: To evaluate whether meteorological parameters influence pain and disease activity in patients with rheumatoid arthritis (RA). Methods: We assessed correlations between individual meteorological variables…
Abstract Number: 272 • 2016 ACR/ARHP Annual Meeting
Interferon Chemokine Score and Other Cytokine Measures Predict Changes in Disease Activity in Patients with Juvenile and Adult Dermatomyositis
Cynthia S. Crowson¹, Jeannette M. Olazagasti Lourido², Molly S. Hein³, Richard S. Pendegraft⁴, Michael A. Strausbauch⁵, Timothy B. Niewold⁶, Floranne C. Ernste⁷, Theresa L. Wampler Muskardin³, Erik J. Peterson⁸, Emily C. Gillespie⁹ and Ann M Reed¹⁰, ¹Health Sciences Research, Mayo Clinic, Rochester, MN, ²University of Puerto Rico, San Juan, Puerto Rico, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Biomedical Statistics and informatics, Rochester, MN, ⁵Surgical Research, Mayo Clinic, Rochester, MN, ⁶Rheumatology and Immunology, Mayo Clinic, Rochester, MN, ⁷Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁸Center for Immunology/Department of Medicine, University of Minnesota, Minneapolis, MN, ⁹Medicine, University of Minnesota, Minneapolis, MN, ¹⁰Rheumatology, Duke University, Durham, NC
Background/Purpose: Methods: Multiplexed immunoassays (Meso Scale Discovery) enabled simultaneous measurement of IFN-regulated chemokines and other pro- and anti-inflammatory cytokines specific to differentiation of specific…
Abstract Number: 556 • 2016 ACR/ARHP Annual Meeting
Higher Multi Biomarker Disease Activity Scores Foreshadow Greater Longitudinal Improvement in RA Disease Activity
Jeffrey Curtis¹, Leslie Harrold², Joel Kremer³ and J. Lynn Palmer⁴, ¹Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²U Massachusetts, Worcester, MA, ³Albany Medical Center, Albany, NY, ⁴Corrona Research Foundation, Albany, NY
Background/Purpose: Biomarkers in patients with rheumatoid arthritis (RA) have the attractive potential to help select patients that have a greater burden of disease activity and…
Abstract Number: 902 • 2016 ACR/ARHP Annual Meeting
High Disease Activity Scores and Leptin Levels in Takayasu Patients with Overweight and Obesity
Gokce Kenar¹, Handan Yarkan², Berrin Zengin¹, Gerçek Can², Merih Birlik¹, Nurullah Akkoc¹ and Fatos Onen¹, ¹Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, ²Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey
Background/Purpose: We aimed to determine the prevalence of overweight, obesity and metabolic syndrome (MetS) and leptin levels in patients with Takayasu arteritis (TA) and their…
Abstract Number: 1375 • 2016 ACR/ARHP Annual Meeting
A Five Year Study of 102 Children with Juvenile Myositis: Disease Course and Outcomes
Lauren M. Pachman^1,2,3, Megan L. Curran⁴, Gabrielle A. Morgan^5,6, Maria C. Amoruso^1,7, Ira N. Targoff^8,9 and Chiang-Ching Huang¹⁰, ¹Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ²Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Rheumatology/Immunology, Ann & Robert H. Lurie Children's Hosptial of Chicago, Chicago, IL, ⁴Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Cure JM Program of Excellence in Myositis Research, Chicago, IL, ⁶Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁷Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹University of Oklahoma, Oklahoma City, OK, ¹⁰Zilber School of Public Health, University of Wisconsin, Milwaukee, Milwaukee, WI
Background/Purpose: Children with juvenile myositis (JM) have a variable disease course, in part associated with myositis specific/associated antibodies (MSA). Time to off medications has not…
Abstract Number: 1553 • 2016 ACR/ARHP Annual Meeting
Declining Flare Rates in the First Five Years of RA Disease, but Not after
Shafay Raheel¹, Cynthia S. Crowson², Eric L. Matteson¹ and Elena Myasoedova¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: Flare or episodic worsening of disease activity is an important aspect of the disease experience for patients with rheumatoid arthritis (RA). Improving trends towards…

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