Abstracts tagged "Disease Activity"

Abstract Number: 1548 • 2016 ACR/ARHP Annual Meeting
Correlates of Fatigue in People Living with Rheumatoid Arthritis
Jet Veldhuijzen van Zanten^1,2, Sally Fenton^3,4, Peter Rouse⁵, George Metsios^3,6, Ahmad Osailan^1,2, Chen-an Yu², Nikos Ntoumanis⁷, Joan Duda⁴ and George Kitas^1,2, ¹Department of Rheumatology, Dudley Group NHS Foundation Trust, Dudley, United Kingdom, ²School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom, ³Department of Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, ⁴School of Sport, Exercise and Rehabilitation, University of Birmingham, Birmingham, United Kingdom, ⁵Department for Health, University of Bath, Bath, United Kingdom, ⁶Department of Physical Activity Exercise and Health, University of Wolverhampton, Walsall, United Kingdom, ⁷School of Psychology & Speech Pathology, Curtin University, Perth, Australia
Background/Purpose: Fatigue is a frequently mentioned symptom by people living with rheumatoid arthritis (RA). However, little research has explored the associations between fatigue and other…
Abstract Number: 1831 • 2016 ACR/ARHP Annual Meeting
A Novel Graph Theoretic Approach Applied to Modular Repertoire Analysis Identifies a Dual Molecular Progression in Adult SLE Patients, with Distinct Interferon and Neutrophil Transcription Patterns
Ilya Korsunski¹, Noémie Jourde-Chiche^2,3, Peter K. Gregersen¹, Damien Chaussabel⁴, Laurent Chiche⁵ and Naomi I Maria⁶, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Vascular Research Center of Marseille, Aix-Marseille Univ., Vascular Research Center of Marseille, Marseille, France, ³Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, ⁴Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, ⁵internal medicine, Hopital Europeen, Marseille, France, ⁶Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Gene expression studies support a pivotal role for type I interferon (IFN) in SLE. Previous work using a modular repertoire analysis based on co-clustered…
Abstract Number: 2468 • 2016 ACR/ARHP Annual Meeting
Assessment of the American-English Version of the French FLARE in Rheumatoid Arthritis
Nashla Barroso¹, Thasia G Woodworth², Francis Guillemin³, Daniel E. Furst⁴, Jenny Brook⁵, Suzanne Kafaja⁶, David Elashoff⁵, Bruno Fautrel⁷ and Veena Ranganath⁸, ¹Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Leading Edge Clinical Research, Stuart, FL, ³CHRU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, ⁴David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁵Medicine, David Geffen School of Medicine, Los Angeles, CA, ⁶Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁷Rheumatology, Pitié Salpêtrière Hospital, Paris, France, ⁸Cumberland Valley Rheumatology, P.C., Chambersburg, PA
Background/Purpose: Due to the lack of consensus of the definition of a rheumatoid arthritis (RA) flare, the French “FLARE” (FLare Assessment in RA) instrument was…
Abstract Number: 2705 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Autophagy Genes and Their Association with Spinal Damage in Patients with Ankylosing Spondylitis
Min-Chan Park¹, Hye Won Kim², Jason Jungsik Song¹ and Yong-Beom Park¹, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: However, a role of autophagy in ankylosing spondylitis has not been clearly elucidated and the association of autophagy-related gene expression levels with inflammatory or…
Abstract Number: 2847 • 2016 ACR/ARHP Annual Meeting
Antibodies to Double Stranded DNA: Combined Standard ELISA and High-Salt ELISA Assays for the Detection of SLE Disease Activity
Laura Durcan, Jenna Thomason, Daniel Kuo and Mark H. Wener, University of Washington, Seattle, WA
Background/Purpose: Serological markers in systemic lupus erythematosus (SLE) are crucial objective measures included in disease activity indices. Antibodies to double stranded DNA (anti-dsDNA) are included…
Abstract Number: 3192 • 2016 ACR/ARHP Annual Meeting
Influence of Temperature and Humidity on Disease Activity in Rheumatoid Arthritis
Peter Mandl¹, Farideh Alasti¹, Rainer Kaltenberger², Thomas Krennert², Gabriela Supp¹, Uriel Landesmann¹, Josef S. Smolen³ and Daniel Aletaha⁴, ¹Department of Internal Medicine III; Division of Rheumatology, Medical University Vienna, Vienna, Austria, ²Central Institute for Meteorology and Geodynamics, Vienna, Austria, ³Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria
Background/Purpose: To evaluate whether meteorological parameters influence pain and disease activity in patients with rheumatoid arthritis (RA). Methods: We assessed correlations between individual meteorological variables…
Abstract Number: 272 • 2016 ACR/ARHP Annual Meeting
Interferon Chemokine Score and Other Cytokine Measures Predict Changes in Disease Activity in Patients with Juvenile and Adult Dermatomyositis
Cynthia S. Crowson¹, Jeannette M. Olazagasti Lourido², Molly S. Hein³, Richard S. Pendegraft⁴, Michael A. Strausbauch⁵, Timothy B. Niewold⁶, Floranne C. Ernste⁷, Theresa L. Wampler Muskardin³, Erik J. Peterson⁸, Emily C. Gillespie⁹ and Ann M Reed¹⁰, ¹Health Sciences Research, Mayo Clinic, Rochester, MN, ²University of Puerto Rico, San Juan, Puerto Rico, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Biomedical Statistics and informatics, Rochester, MN, ⁵Surgical Research, Mayo Clinic, Rochester, MN, ⁶Rheumatology and Immunology, Mayo Clinic, Rochester, MN, ⁷Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁸Center for Immunology/Department of Medicine, University of Minnesota, Minneapolis, MN, ⁹Medicine, University of Minnesota, Minneapolis, MN, ¹⁰Rheumatology, Duke University, Durham, NC
Background/Purpose: Methods: Multiplexed immunoassays (Meso Scale Discovery) enabled simultaneous measurement of IFN-regulated chemokines and other pro- and anti-inflammatory cytokines specific to differentiation of specific…
Abstract Number: 556 • 2016 ACR/ARHP Annual Meeting
Higher Multi Biomarker Disease Activity Scores Foreshadow Greater Longitudinal Improvement in RA Disease Activity
Jeffrey Curtis¹, Leslie Harrold², Joel Kremer³ and J. Lynn Palmer⁴, ¹Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²U Massachusetts, Worcester, MA, ³Albany Medical Center, Albany, NY, ⁴Corrona Research Foundation, Albany, NY
Background/Purpose: Biomarkers in patients with rheumatoid arthritis (RA) have the attractive potential to help select patients that have a greater burden of disease activity and…
Abstract Number: 902 • 2016 ACR/ARHP Annual Meeting
High Disease Activity Scores and Leptin Levels in Takayasu Patients with Overweight and Obesity
Gokce Kenar¹, Handan Yarkan², Berrin Zengin¹, Gerçek Can², Merih Birlik¹, Nurullah Akkoc¹ and Fatos Onen¹, ¹Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, ²Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey
Background/Purpose: We aimed to determine the prevalence of overweight, obesity and metabolic syndrome (MetS) and leptin levels in patients with Takayasu arteritis (TA) and their…
Abstract Number: 1375 • 2016 ACR/ARHP Annual Meeting
A Five Year Study of 102 Children with Juvenile Myositis: Disease Course and Outcomes
Lauren M. Pachman^1,2,3, Megan L. Curran⁴, Gabrielle A. Morgan^5,6, Maria C. Amoruso^1,7, Ira N. Targoff^8,9 and Chiang-Ching Huang¹⁰, ¹Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ²Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Rheumatology/Immunology, Ann & Robert H. Lurie Children's Hosptial of Chicago, Chicago, IL, ⁴Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Cure JM Program of Excellence in Myositis Research, Chicago, IL, ⁶Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁷Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹University of Oklahoma, Oklahoma City, OK, ¹⁰Zilber School of Public Health, University of Wisconsin, Milwaukee, Milwaukee, WI
Background/Purpose: Children with juvenile myositis (JM) have a variable disease course, in part associated with myositis specific/associated antibodies (MSA). Time to off medications has not…
Abstract Number: 1553 • 2016 ACR/ARHP Annual Meeting
Declining Flare Rates in the First Five Years of RA Disease, but Not after
Shafay Raheel¹, Cynthia S. Crowson², Eric L. Matteson¹ and Elena Myasoedova¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: Flare or episodic worsening of disease activity is an important aspect of the disease experience for patients with rheumatoid arthritis (RA). Improving trends towards…
Abstract Number: 1903 • 2016 ACR/ARHP Annual Meeting
Determining Disease Course in Localized Scleroderma: A Prospective Cohort Study
Jack O'Brien¹ and Heidi Jacobe², ¹Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA, Dallas, TX, ²Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Localized scleroderma (LS) is characterized by skin sclerosis, producing devastating impairment in those affected. It was previously thought to “burn out” within 5 years,…
Abstract Number: 2470 • 2016 ACR/ARHP Annual Meeting
Treat to Target: Theoretical Agreement Vs Daily Applicability
Leonardo Romeiro¹, Dalton Torigoe², Claiton Brenol³, Roberto Ranza⁴, Lícia M. H. Mota⁵, Manoel Bertolo⁶, Max Freitas⁷, José Tupinambá⁸, Ivanio Pereira⁹, Lucila Fronza¹⁰ and Ieda Maria Magalhães Laurindo¹¹, ¹Rheumatology, UNESA, Rio de Janeiro, Rio de Janeiro, Brazil, ²Faculdade de Medicina da Santa Casa de Misericordia, São Paulo, Brazil, ³Rua Cabral, 764 – Apto 302, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ⁴Reumatologia, Reumatologia, Universidade Federal de Uberlandia, Uberlandia, Brazil, ⁵Hospital Universitário de Brasília - UnB, Brasília, Brazil, ⁶INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil, ⁷Pathology, Federal University of Ceara, Fortaleza, Brazil, ⁸Universidade Federal do Piaui, Teresina, Brazil, ⁹Rheumatology, Universidade do Sul de Santa Catarina, Florianopolis, Brazil, ¹⁰CETI - Centro de Estudos em Terapias Inovadoras, Curitiba, Brazil, ¹¹Internal Medicine - Rheumatology, Faculdade de Medicina da Universidade Nove de Julho, São Paulo, Brazil
Background/Purpose: Treat to target (T2T) strategy has been widely recognized as effective and leading to better outcomes. There have been no questions regarding its theoretical…
Abstract Number: 2713 • 2016 ACR/ARHP Annual Meeting
Differentially Expressed Microrna As Candidate Biomarker for Disease Activity in Ankylosing Spondylitis
Marina N. Magrey¹, Abdul Haseeb² and Tariq M Haqqi², ¹Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Differentially Expressed MicroRNA as candidate Biomarker for Disease Activity in Ankylosing Spondylitis Background/Purpose: MicroRNAs (miRNAs) have evolved as a novel class of biomarkers We proposed…
Abstract Number: 2860 • 2016 ACR/ARHP Annual Meeting
Exercise Significantly Improves Cardiorespiratory Fitness and Reduces Disease-Related Fatigue without Adverse Effects on Disease Activity in Systemic Lupus Erythematosus: a Systematic Review with Meta-Analysis
Tom O'Dwyer¹, Laura Durcan² and Fiona Wilson³, ¹Physiotherapy, Trinity College Dublin, Dublin, Ireland, ²University of Washington, Seattle, WA, ³Physiotherapy, Trinity College, Dublin, Ireland
Background/Purpose: Systemic lupus erythematous (SLE) associates with accelerated mortality, frequently attributable to cardiovascular (CV) causes, which is not fully explained by traditional CV risk factors.…

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