ACR Meeting Abstracts

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Abstracts tagged "Disease Activity"

  • Abstract Number: 1462 • 2018 ACR/ARHP Annual Meeting

    Fibrin Deposition and Neutrophil Infiltration of Rheumatoid Arthritis Synovium Are Associated with Duration of Morning Stiffness

    Dana Orange1, Caroline Jiang1, Edward F. DiCarlo2, Tania Pannellini3, Laura T. Donlin4, Serene Z. Mirza5, Mark P. Figgie6, Vivian P. Bykerk7, Ana-Maria Orbai8, Sarah Mackie9 and Susan M. Goodman3, 1Rockefeller University, New York, NY, 2Laboratory Medicine, Hospital for Special Surgery, New York, NY, 3Hospital for Special Surgery, New York, NY, 4Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 5Rheumatology, Hospital for Special Surgery, New York, NY, 6Surgery, Hospital for Special Surgery, New York, NY, 7Deptartment of Rheumatology, Hospital for Special Surgery, New York, NY, 8Johns Hopkins University School of Medicine, Baltimore, MD, 9NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Stiffness is a hallmark of RA, but little is known about the etiology. We investigated stiffness association with RA disease activity and determined whether…
  • Abstract Number: 1675 • 2018 ACR/ARHP Annual Meeting

    Lupus Impact Tracker Responds to Changes in Low Disease Activity and Remission Outcomes in a Large Spanish Lupus Registry Cohort

    Meenakshi Jolly1, Hervé Devilliers2, Iñigo Rúa-Figueroa3, Desiree R Azizoddin4, Raúl Menor Almagro5, Francisco Javier López Longo6, Juan Gabriel Ovalles-Bonilla7, Alejandro Olivé-Marques8, Paula Rubio-Muñoz8, María Galindo-Izquierdo9, Antonio Fernandez-Nebro10, Jaime Calvo-Alen11, Txaro García de Vicuña-Pinedo12, Eva G Tomero-Muriel13, Esther Uriarte Isacelaya14, Angela Pecondon-Español15, Mercedes Freire-González16, Ricardo Blanco17, Marian Gantes Mora18, Monica Ibanez Barcelo19, Carlos Alberto Montilla-Morales20, José José C Rosas-Gómez de Salazar21, Jesús García-Villanueva22, Paloma Vela-Casasempere23, María E Ruiz-Lucea24, Francisco J Toyos-Sáenz-de-Miera25, José Hernández Beiraín26, Elvira Diez Alvarez27, Gema Bonilla-Hernán28, Javier Narváez-García29, José Andréu-Sánchez30, Mireia Moreno-Martínez-Losa31, Ana Sánchez Atrio32, Maria Loreto Horcada33, Tatiana Cobo-Ibáñez34, Carlos Marras Fernandez-Cid35, Tomas Ramón Vazquez Rodriguez36, Eva Salgado-Pérez37, Vicente Torrente38, Juan Alegre-Sancho39, Coral Mouriño-Rodriguez40, Joel A. Block1 and JM Pego-Reigosa41, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2de médecine Interne, Hôpital Universitaire Dijon, Dijon, France, 3Rheumatology Division, Hospital Doctor Negrin, Las Palmas GC, Spain, 4Department of Anesthesiology, Stanford University School of Medicine, Palo Alto, CA, 5Rheumatology, Hospital de Jerez de la Frontera, Jerez, Spain, 6Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 7Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, 8Rheumatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 9Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, 10UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain, 11Rheumatology, Txagorritxu Hospital, Araba, Vitoria, Vitoria, Spain, 12Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 13Rheumatology, Hospital de La Princesa. Madrid. Spain, Madrid, Spain, 14Rheumatology, Hospital Universitario de Donosti, San Sebastian, Spain, 15Rheumatology, Hospital Miguel Servet, Zaragoza, Spain, 16Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo HospitalarioUniversitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 17Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 18Rheumatology, Hospital Universitario de Canarias, La Laguna; Tenerife, Spain, 19H. Son Llatzer, Palma de Mallorca, Spain, 20Hospital Clínico Universitario de Salamanca. Spain, Salamanca, Spain, 21Rheumatology, Hospital Marina Baixa, Villajoyosa (Alicante), Spain, 22HOSPITAL RAMÓN Y CAJAL, Madrid, Spain, 23Dpt. Rheumatology, Hospital General Universitario Alicante, Alicante, Spain, 24Rheumatology, Hospital de Basurto, Bilbao, Spain, 25Rheumatology, Hospital Universitario Virgen de la Macarena, Sevilla, Spain, 26Rheumatology, Hospital Insular de Gran Canaria, Las palmas Gran Canarias, Spain, 27Complejo Asistencial Universitario de León, León, Spain, 28Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, 29Rheumatology Department, Hospital de Bellvitge. Barcelona. Spain, L’Hospitalet de Llobregat, Spain, 30HOSPITAL PUERTA DE HIERRO, Madrid, Spain, 31HOSPITAL PARC TAULÍ, Barcelona, Spain, 32University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology Department, Alcalá de Henares, Madrid, Spain, 33Rheumatology, Hospital de Navarra, Pamplona, Spain, 34Hospital Universitario Reina Sofía, Universidad Europea de Madrid, Madrid, Spain, 35Rheumatology, Hospital Virgen de la Arrixaca, Murcia, Spain, 36Rheumatology, Hospital Universitario Lucus Augusti, Lugo, Spain, 37COMPLEJO HOSPITALARIO DE OURENSE, Ourense, Spain, 38Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain, 39HOSPITAL DR. PESET, València, Spain, 40Rheumatology, Rheumatology Section, Complexo Hospitalario Universitario de Vigo, Pontevedra, Spain, Vigo, Spain, 41Complexo Hospitalario Universitario de Vigo, Vigo, Spain

    Background/Purpose: Remission & Low Disease activity state (LDAS) are the two new health outcome measures developed with “treat to target” strategy in mind for Systemic…
  • Abstract Number: 2041 • 2018 ACR/ARHP Annual Meeting

    Serum Level of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1): A New Biomarker of Disease Activity in Rheumatoid Arthritis

    Clémence Gorlier1, Hafid Ait Oufella2, Ludivine Laurans2, Alexandra Rousseau3, Sophie Georgin-Lavialle4, Harry Sokol5, Francis Berenbaum1, Simon Tabassome6, Jacques-Eric Gottenberg7 and Jeremie Sellam1, 1AP-HP Saint-Antoine hospital, Service de Rhumatologie, Inserm UMRS_938, Paris, France, 2Inserm U970, Paris Cardiovascular Research Center, Paris, France, 3AP-HP Saint-Antoine Hospital, Plateforme de Recherche Clinique de l’Est Parisien (URCEST-CRCEST-CRB, Paris, France, 4AP-HP Tenon hospital, Sorbonne Université Paris, Paris, France, 5AP-HP Saint-Antoine hospital, Sorbonne Université Paris, France, Paris, France, 6AP-HP Saint-Antoine Hospital, Plateforme de Recherche Clinique de l’Est Parisien (URCEST-CRCEST-CRB), Paris, France, 7Department of Rheumatology, Strasbourg University Hospital, Université de Strasbourg, CNRS, Strasbourg, France, Strasbourg, France

    Background/Purpose: Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) is a cell surface receptor expressed mainly on monocytes and neutrophils, known to amplify inflammatory response. We…
  • Abstract Number: 2489 • 2018 ACR/ARHP Annual Meeting

    In Clinical Practice a Substantial Group of Rheumatoid Arthritis (RA) Patients on Biologic Therapy (bDMARDs) Has Persistent Moderate Disease Activity Despite Treatment Switches That Correlates with Unfavourable Long-Term Outcome

    Irini Genitsaridi1,2, Irini Flouri3, Argyro Repa2, Nestor Avgoustidis2, Nikolaos Kougkas2, Ioannis Papalopoulos2, Styliani Polia2, Konstantinos Marias1, Dimitris Plexousakis4, George Bertsias2 and Prodromos Sidiropoulos2, 1Computational BioMedicine Laboratory, Institute of Computer Science, Foundation for Research and Technology-Hellas, Heraklio, Greece, 2Department of Rheumatology, Clinical Immunology and Allergy, University of Crete, School of Medicine, Heraklion, Greece, 3Department of Rheumatology, Clinical Immunology and Allergy, University of Crete, School of Medicine, Heraklio, Greece, 4Information Systems Laboratory, Institute of Computer Science, Foundation for Research and Technology-Hellas, Heraklio, Greece

    Background/Purpose: Registry data have shown that treatment with bDMARDs induces remission or LDA (RLDA) in up-to 50% of RA patients. Approximately 30-50% of patients have…
  • Abstract Number: 2835 • 2018 ACR/ARHP Annual Meeting

    Association between Changes in Gene Signature Expression and Disease Activity in Systemic Lupus Erythematosus

    Michelle Petri1, Wei Fu1, Ann Ranger2, Normand Allaire2, Patrick Cullen3 and Laurence S Magder4, 1Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, 2Biogen Idec, Cambridge, MA, 3Biogen Idec, Cambridge, MD, 4Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: We assessed the stability of BAFF, interferon, plasma cell and LDG neutrophil gene expression signatures over time, and whether changes in gene expression coincided…
  • Abstract Number: 386 • 2018 ACR/ARHP Annual Meeting

    Differences in Body Composition in Myositis Patients and Healthy Controls Are Associated with Disease Activity and Duration, Inflammatory Status, Skeletal Muscle Involvement and Physical Activity

    Sabina Oreska1,2, Maja Spiritovic1,3, Petr Cesak4, Ondrej Marecek5, Hana Storkanova1,2, Hana Smucrova1, Barbora Hermankova1,3, Katerina Kubinova1,2, Martin Klein1,2, Lucia Vernerova1,2, Olga Ruzickova1,6, Karel Pavelka1,2, Ladislav Šenolt1,2, Herman F Mann1,7, Jiri Vencovsky1,8 and Michal Tomcik1,2, 1Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 2Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Department of Physiotherapy, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Body Composition Laboratory, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5Physiotherapy, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 7First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 8Department Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Skeletal muscle, pulmonary and articular involvement in idiopathic inflammatory myopathies (IIM) limit the mobility/self-sufficiency of patients, and can have a negative impact on body…
  • Abstract Number: 822 • 2018 ACR/ARHP Annual Meeting

    Immuno-Inflammatory Markers and MR-Angiographic Imaging to Detect Disease Activity in Takayasu Arteritis

    Andrea D. Gloor1, Daniel Yerly2, Jennifer L. Cullmann3, Sabine Adler1 and Peter M. Villiger1, 1Department of Rheumatology, Immunology and Allergology, Inselspital, University Hospital of Bern, Bern, Switzerland, 2Department of Biomedical Research, University of Bern, Bern, Switzerland, 3Institute of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital of Bern, Bern, Switzerland

    Background/Purpose: There is an unmet need for tools to quantify local disease activity in TAK.Methods: Sera of 21 TAK patients, aged between 18 and 56…
  • Abstract Number: 1467 • 2018 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Activity Monitoring and Multiplex Biomarker Verification By Tageted Proteomics

    Lucía González-Rodríguez1, Valentina Calamia1, Patricia Fernández2, Cristina Ruiz-Romero3, Antonio Julià4, Antonio Fernández-Nebro5, Jesús Tornero6, Sara Marsal4 and Francisco J Blanco3, 1Proteomics Group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 2Proteomics group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, La Coruña, Spain, 3Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 4Rheumatology Research Group, Vall d’Hebron Hospital Research Institute, Barcelona, Spain., Barcelona, Spain, 5UGC Reumatología, Instituto de Investigación Biomédica (IBIMA), Hospital Regional Universitario de Málaga, Spain., Málaga, Spain, 6Hospital Universitario Guadalajara, Guadalajara, Spain., Guadalajara, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is a long-lasting inflammatory autoimmune disorder that ultimately leads to the destruction of joint architecture. The activity of this disease is…
  • Abstract Number: 1676 • 2018 ACR/ARHP Annual Meeting

    Health Related Quality of Life over Time in a Multi-Ethnic Cohort of Patients with Systemic Lupus Erythematosus and Correlation with Disease Activity and Organ Damage

    Muhammad Mehmood Riaz1,2, Liang SHEN3, Lay Kheng Teoh4, Rangi Kandane-Rathnayake5 and Aisha Lateef6, 1Department of Medicine, National University Hospital, Singapore, Singapore, 2Department of Medicine, Aga Khan University, karachi, Pakistan, 3Biostatistics Unit, National University Health System, Singapore, Singapore, 4National University Hospital, Division of Rheumatology, University Medicine Cluster, Singapore, Singapore, 5School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, 6Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

     Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic disease affecting the physical, social, and psychological well-being of patients. Health related quality of life (HRQoL) measures…
  • Abstract Number: 2086 • 2018 ACR/ARHP Annual Meeting

    4-Phenylbutyric Acid Mediates Therapeutic Effect in Systemic Lupus Erythematosus: Observations in an Experimental Murine Lupus Model

    Yunjung Choi1, Ji-hyun Jung2, Eun-Kyeong Lee2, Myeung Su Lee3, Changhoon Lee4 and Wan-Hee Yoo5, 1Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of chonbuk national university-Biomedical Research Institute of chonbuk national university hospital, jeonju, Korea, Republic of (South), 2Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea, Republic of (South), 3Department of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), 5Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of chonbuk national university-Biomedical Research Institute of chonbuk national university hospital, Jeonju, Korea, Republic of (South)

    Background/Purpose: The purpose of the present study was to investigate whether ER stress inhibition by 4-phenylbutyric acid (4-PBA) ameliorates lupus manifestations in an experimental lupus…
  • Abstract Number: 2491 • 2018 ACR/ARHP Annual Meeting

    Treat-to-Target (T2T) Is Not Enough: Identify Factors Leading to a Mismatch between T2T and HAQ Among RA Patients through Data Mining from Smart System of Disease Management (SSDM)

    Jing Yang1, Hua Wei2, Jianlin Huang3, Wenqiang Fan4, Hongzhi Wang5, Yongfu Wang6, Rong Mu7, Chun Li8, Jinmei Zou1, Yu Zhang1, Bin Wu9, Jianling Dong1, Xiaofei Shi10, Xinwang Duan11, Jianhong Wu12, Fang He13, Hong Liu1, Zhijun Li14, Guosheng Wang15, Shengguang Li16, Bei Wang17, Yanjie Hao18, Huiqiong Zhou19, Haili shen20, Yang Cui21, Wenhui Huang22, Qing-chun Huang23, Hui Xiao24, Yuhua Jia24, Fei Xiao24 and Feng-Chun Zhang25, 1Department of rheumatology, Central Hospital of MianYang, Sichuan, Mian Yang, China, 2Northern Jiangsu People's Hospital, Yangzhou, China, 3Department of rheumatology, The Sixth Hospital Affiliated to Sun yat-sen University, Guangzhou, China, 4Department of rheumatology, Central Hospital of XinXiang, Henan, XinXiang, China, 5The First Hospital of Jiaxing, Jiaxing, China, 6The First Affiliated Hospital of BaoTou Medical College, Baotou, China, 7Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 8Peking University People's Hospital, Beijing, China, 9Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China, 10The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China, 11Department of rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China, 12Dazhou Central Hospital, Dazhou, China, 13Central Hospital of Sui Ning, Sichuan, Suining, China, 14The First Affiliated Hospital of Bengbu Medical College, Bengbu, China, 15Department of rheumatology, Anhui Medical University Affiliated Provincial Hospital, Hefei, China, 16Peking University International Hospital, Beijing, China, 17Beijing Hospital of Traditional Chinese Medicine (TCM), Beijing, China, 18The First Affiliated Hospital of Beijing University, Beijing, China, 19The First Affiliated Hospital of PLA General Hospital, Beijing, China, 20Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, lanzhou, China, 21Guangdong General Hospital, Guangzhou, China, 22The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 23Rheumatology, Guangzhou Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China, 24Shanghai Gothic Internet Technology Co., Ltd., Shanghai, China, 25Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: T2T, achieving a DAS28 score lower than 3.2 is the main management strategy recommended by ACR and EULAR. HAQ is the most widely used…
  • Abstract Number: 2856 • 2018 ACR/ARHP Annual Meeting

    Do Patients with Moderate or High Disease Activity Escalate RA Therapy According to Treat-to-Target Principles? Results from the Acr’s RISE Registry

    Huifeng Yun1, Lang Chen1, Fenglong Xie1, Himanshu Patel2, Natalie Boytsov2, Xiang Zhang2 and Jeffrey R. Curtis1, 1University of Alabama at Birmingham, Birmingham, AL, 2Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Routine measurement of RA disease activity and adjustment of drug therapy to attain remission or low disease activity is recommended by the ACR and…
  • Abstract Number: 9L • 2017 ACR/ARHP Annual Meeting

    Circulating Type I, II and III Interferons (IFNs) Associate with IFN-Scores, but Define Distinct Subsets of Active SLE

    Vilija Oke1, Iva Gunnarsson1, Jessica M. Dorschner2, Agneta Zickert1, Timothy B. Niewold3 and Elisabet Svenungsson1, 1Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 2Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 3Colton Center for Autoimmunity, New York University, New York, NY

    Background/Purpose: Serum induced IFN gene expression (IFN-score) is considered a golden standard to assess IFN activity in SLE. So far, IFN-scores have not been compared…
  • Abstract Number: 432 • 2017 ACR/ARHP Annual Meeting

    ACPA and RF As Predictors of Sustained Clinical Remission in Rheumatoid Arthritis Patients: Data from a Rheumatoid Arthritis Cohort

    Janet E. Pope1, Emmanouil Rampakakis2, Mohammad Movahedi3, Angela Cesta3, John S. Sampalis4 and Claire Bombardier3, 1Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada, 2JSS Medical Research, Montreal, QC, Canada, 3Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 4McGill University, Montreal, QC, Canada

    ACPA and RF as Predictors of Sustained Clinical Remission in Rheumatoid Arthritis Patients: Data From a Rheumatoid Arthritis CohortBackground/Purpose: Positive serology for anti-citrullinated protein antibody…
  • Abstract Number: 870 • 2017 ACR/ARHP Annual Meeting

    Detection of Left Ventricular Regional Function in Rheumatoid Arthritis Patients without Cardiac Symptons, As Assessed By Feature Tracking Cardiac Magnetic Resonance Imaging

    Hitomi Kobayashi1, Yasuyuki Kobayashi2, Isamu Yokoe3, Akiyuki Kotoku4, Atsuma Nishiwaki5, Kaita Sugiyama6, Noboru Kitamura5 and Masami Takei5, 1Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 2Advanced Biomedical Imaging Informatics, St.Marianna University School of Medicine, Kawasaki, Japan, 3Rheumatology, Kyoundo Hospital, Sasaki Institute, Tokyo, Japan, 4Advanced Biomedical Imaging Informatics, St. Marianna University School of Medicine, Kawasaki, Japan, 5Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 6Nihon University School of Medicine, Tokyo, Japan

    Background/Purpose: Cardiac involvements cause of morbidity and mortality globally in rheumatoid arthritis (RA). Myocardial disease is typically clinically silent, only manifesting as myocardial dysfunction after…
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