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Abstracts tagged "Disease Activity"

  • Abstract Number: 0173 • ACR Convergence 2022

    Cutaneous Manifestations, Clinical Trials, Safety Efficacy and Safety of Lenabasum in the Phase 3 DeterMine Trial in Dermatomyositis

    Victoria Werth1, Barbara White2, Josef Concha3, Josh Dan1, Nancy Dgetluck2, Kathleen Hally2, Scott Constantine2, Rohit Aggarwal4, David Fiorentino5, Ingrid Lundberg6 and Chester Oddis7, 1Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 2Corbus Pharmaceuticals, Norwood, MA, 3Universiity of Pennsylvania/Dermatology, Philadelphia, PA, 4University of Pittsburgh, Division of Rheumatology, Pittsburgh, PA, 5Stanford university/Department of Dermatology, Palo Alto, CA, 6Karolinska Institute, Stockholm, Sweden, 7University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Safe and effective treatments are of significant unmet need in DM. Lenabasum, a CB2 agonist that activates resolution of inflammation, improved skin disease, patient-reported…
  • Abstract Number: 0421 • ACR Convergence 2022

    Efficacy and Safety of Tofacitinib in Patients with Ankylosing Spondylitis by Prior bDMARD Treatment: Analysis of a Phase 3 Trial

    Atul Deodhar1, Helena Marzo-Ortega2, Joseph Wu3, Cunshan Wang3, Oluwaseyi Dina4, Keith S Kanik3, Lara Fallon5 and Lianne Gensler6, 1Oregon Health & Science University, Portland, OR, USA, Portland, OR, 2Leeds Teaching Hospitals Trust and University of Leeds, Leeds, United Kingdom, 3Pfizer Inc, Groton, CT, 4Pfizer Inc, New York, NY, 5Pfizer Inc, Montréal, QC, Canada, 6Department of Medicine, Division of Rheumatology, University of California San Francisco, San Francisco, CA

    Background/Purpose: Prior exposure to biologic (b)DMARD therapy of patients (pts) with AS may influence treatment response.1-3 Tofacitinib is an oral JAK inhibitor for the treatment…
  • Abstract Number: 0858 • ACR Convergence 2022

    Predicting the Occurrence of Drug-Free Inactive Disease Two Years After Diagnosis of Non-Systemic Juvenile Idiopathic Arthritis

    Melissa Mannion1, Chen Chen2, Olha Halyabar3, Susan Paetkau4, Tingting Qiu5 and Bin Huang6, 1University of Alabama at Birmingham, Birmingham, AL, 2Cincinnati Children's Hospital Medical Center, Taipei, Taiwan, 3Children's Hospital/Boston Medical Center, Boston, MA, 4The Hospital for Sick Children, Toronto, ON, Canada, 5Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Cincinnati Children's Hospital Medical Center, Cinciannati, OH

    Background/Purpose: The goal of treatment for juvenile idiopathic arthritis (JIA) is inactive disease (ID), but the optimal treatment for each patient to maximize ID and…
  • Abstract Number: 1033 • ACR Convergence 2022

    Risk of Mood Disorders in SpA Patients and Correlations with Disease Activity, Quality of Life and Working Ability: Analysis of a Monocentric Cohort

    Cosimo Cigolini1, Federico Fattorini1, Linda Carli2, Andrea Delle Sedie3, Marta Mosca2 and Gabriele Marchetti4, 1Rheumatology Unit, University of Pisa, Pisa, Toscana, Italy, 2Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, PISA, Italy, 3University of Pisa, Pisa, Pisa, Italy, 4University of Pisa, Pisa, Toscana, Italy

    Background/Purpose: Spondyloarthropathies (SpA) are chronic inflammatory arthritides, characterized by both peripheral and axial skeletal involvement and some typical extra-articular marks; they tend to associate with…
  • Abstract Number: 1401 • ACR Convergence 2022

    Relationship Between Disease Activity and Adverse Events of Interest in Patients with RA on Tofacitinib or TNF Inhibitors: Post Hoc Analysis of a Phase 3b/4 Randomized Safety Study

    George A Karpouzas1, Zoltan Szekanecz2, Eva Baecklund3, Ted Mikuls4, Deepak L Bhatt5, Harry Shi6, Cunshan Wang7, Gosford A Sawyerr8, Yan Chen6, Sujatha Menon7, Carol A Connell7, Steven R Ytterberg9 and Mahta Mortezavi8, 1Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 2Division of Rheumatology, Faculty of Medicine, Debrecen, Hungary, 3Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 4Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5Department of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 6Pfizer, Inc, Collegeville, PA, 7Pfizer Inc, Groton, CT, 8Pfizer Inc, New York, NY, 9Division of Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose: Uncontrolled RA activity and acute disease flares are associated with higher risk of adverse outcomes, such as cardiovascular (CV) disease, venous thromboembolism (VTE), malignancy,…
  • Abstract Number: 1544 • ACR Convergence 2022

    Is It Possible to Evaluate Polymyalgia Rheumatica Without C-reactive Protein? Concordance and Agreement Between Different PMR Activity Scores in Polymyalgia Rheumatica

    Justine D'agostino1, Valerie Devauchelle1, Guillermo CARVAJAL ALEGRIA2, Emmanuelle Dernis3, Christophe Richez4, Marie Truchetet5, Daniel Wendling6, ERIC TOUSSIROT7, aleth Perdriger8, jacques-eric gottenberg9, Renaud FELTEN10, Bruno Fautrel11, laurent chiche12, Pascal HILLIQUIN13, Catherine Le Henaff14, Benjamin Dervieux15, Guillaume Direz16, Isabelle Chary-Valckenaere17, Divi CORNEC18, Dewi Guellec19, Thierry MARHADOUR20, Aghiles Souki19, Emmanule Nowak19 and Alain Saraux21, 1Université de Bretagne Occidentale, Brest, France, 2CHRU de Tours, Tours, France, 3LE MANS general hospital, LE MANS, France, 4Université de Bordeaux, Bordeaux, France, 5Bordeaux University Hospital, Bordeaux, France, 6CHU, University Teaching Hospital, Besançon, France, 7CHU de Besançon, Besançon, France, 8Rennes University, Rennes, France, 9Strasbourg University Hospital, Strasbourg, France, 10Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 11Pitié Salpêtrière Hospital, Paris, France, 12hopital europeen, Marseille, France, 13Centre Hospitalier Sud-Francilien, Corbeil-Essonnes, France, 14Morlaix Hospital, Morlaix, France, 15Mulhouse Hospital, Mulhouse, France, 16Le Mans Hospital, Le Mans, France, 17Nancy University Hospital, Vandoeuvre, France, 18CHRU Brest, Brest, France, 19Brest University Hospital, Brest, France, 20CHU Cavale Blanche, Brest, France, 21CHU Brest, Brest, France

    Background/Purpose: Today, the only disease activity score developed specifically for polymylagia rheumatica is the PMR-AS. It is a composite index built as an algebraic sum…
  • Abstract Number: 1986 • ACR Convergence 2022

    Early-stage Rheumatoid Arthritis Patients with High Levels of Type III Collagen Are Less Likely to Respond to Anti-IL6R Treatment

    Sofie Falkenløve Madsen1, Dovile Sinkeviciute2, Christian Thudium2, Morten Karsdal2 and Anne-Christine Bay-Jensen2, 1University of Copenhagen / Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic, autoimmune disease, which normally is characterized by inflammation and thickening of the synovial membrane leading to swollen and…
  • Abstract Number: 2109 • ACR Convergence 2022

    Domains Contributing to Minimal Disease Activity Non-Achievement in Patients with Psoriatic Arthritis Receiving Golimumab: Post Hoc Analysis of a Phase 3, Randomized, Double-blind, Placebo-controlled Study

    Arthur Kavanaugh1, Gordon Lam2, Lai-shan Tam3, Natalie Shiff4, Youngja Lee5, Ana-Maria Bravo Perdomo6, May Shawi7, Elizabeth Hsia8, Emmanouil Rampakakis9 and Carlos Enrique Toro Gutiérrez10, 1University of California San Diego, La Jolla, CA, 2Arthritis and Osteoporosis Consultants of the Carolinas; Clinical Affiliate, Atrium Health and the Wake Forest School of Medicine, Cornelius, NC, 3The Chinese University of Hong Kong, Hong Kong, China, 4Janssen Scientific Affairs, LLC, Horsham, PA, USA/ Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada, Philadelphia, PA, 5Immunology Medical Affairs, Janssen Asia Pacific, Yongsan-gu, Seoul, Republic of Korea, 6Immunology Medical Affairs, Janssen Latin America, Columbia, Colombia, 7Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 8Janssen Research and Development, LLC; University of Pennsylvania School of Medicine, Kennett Square, PA, 9McGill University, Department of Pediatrics and JSS Medical Research, Montréal, QC, Canada, 10Internal Medicine and Rheumatology, Reference Center for Osteoporosis, Rheumatology & Dermatology. Pontificia Javeriana University, Calí, Colombia

    Background/Purpose: Sustained minimal disease activity (MDA) is only achieved by a small portion of PsA patients (pts). Levels of disease activity consistent with MDA may…
  • Abstract Number: 0243 • ACR Convergence 2022

    Real World Evidence of Treatment Effectiveness and Unfavorable Clinical Events for Elderly-onset Early Rheumatoid Arthritis in Japan: Results from the IORRA Study

    Naohiro Sugitani1, Eiichi Tanaka1, Eisuke Inoue2, Kotaro Watanabe3, Mai Abe3, Eri Sugano3, Kumiko Saka3, Moeko Ochiai3, Rei Yamaguchi3, Katsunori Ikari4 and Masayoshi Harigai1, 1Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan, 2Research Administration Center, Showa University, Shinagawa-ku, Japan, 3Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Shinjuku-ku, Japan, 4Department of Orthopedic Surgery, Tokyo Women’s Medial University School of Medicine, Shinjuku, Japan

    Background/Purpose: The number of elderly patients with rheumatoid arthritis (RA) has been constantly increasing. As of December 2021, 50.3% of the patients with RA who…
  • Abstract Number: 0424 • ACR Convergence 2022

    The Efficacy and Safety of CT-P13 as First-line and Subsequent-line Therapy in Patients with Ankylosing Spondylitis: Real-life Data from TURKBIO Cohort

    Sadettin Uslu1, Semih Gulle1, Gercek Can2, Soner Senel3, Sedat Capar4, Huseyin ediz dalkilic5, Servet Akar6, Suleyman Serdar Koca7, Abdurrahman Tufan8, Ayten Yazici9, Sema Yilmaz10, Nevsun Inanc11, Merih Birlik1, Dilek Solmaz12, Ayse Cefle9, Berna Goker13, Servet Yolbas14, Niels Steen Krough15, Neslihan Yilmaz16, Sukran Erten17, Cemal Bes18, Ozgul Soysal19, Mehmet Akif Ozturk13, Seminur Haznedaroglu13, Sule Yavuz16, Haner Direskeneli20, Fatoş Onen21 and Ismail Sari22, 1Dokuz Eylul University School of Medicine Division of Rheumatology, Izmir, Turkey, 2Dokuz Eylul University School of Medicine Division of Rheumatology, Istanbul, Turkey, 3Erciyes University School of Medicine Division of Rheumatology, Kayseri, Turkey, 4Dokuz Eylul University Faculty of Science Department of Statistics, Izmir, Turkey, 5Uludag University School of Medicine Division of Rheumatology, Bursa, Turkey, 6Izmir Katip Celebi University School of Medicine, Izmir, Turkey, 7Firat University School of Medicine Division of Rheumatology, Elazıg, Turkey, 8Gazi University Medical Faculty Hospital, Istanbul, Turkey, 9Kocaeli University School of Medicine Division of Rheumatology, Kocaeli, Turkey, 10Selcuk University School of Medicine Division of Rheumatology, Konya, Turkey, 11Marmara University School of Medicine, Division of Rheumatology, Istanbul, Turkey, 12Kâtip Celebi University School of Medicine Division of Rheumatology, Izmir, Turkey, 13Gazi University School of Medicine Division of Rheumatology, Ankara, Turkey, 14Inonu University School of Medicine Division of Rheumatology, Malatya, Turkey, 15Zitelab Aps, Kopenhag, Denmark, 16Demiroglu Bilim University School of Medicine Division of Rheumatology, Istanbul, Turkey, 17Yildirim Beyazit University School of Medicine Division of Rheumatology, Ankara, Turkey, 18Basaksehir Cam and Sakura ospital, Division of Rheumatology, Istanbul, Turkey, 19Celal Bayar University, School of Medicine Division of Rheumatology, Manisa, Turkey, 20Marmara University School of Medicine Division of Rheumatology, Istanbul, Turkey, 21Dokuz Eylul University, Faculty of Medicine, Rheumatology, İzmir, Turkey, 22Dokuz Eylul University School of Medicine Division of Rheumatology, İzmir, Turkey

    Background/Purpose: In this study, it was aimed to evaluate the long-term drug survival, efficacy and safety of infliximab biosimilar CT-P13 in Turkish patients diagnosed with…
  • Abstract Number: 0876 • ACR Convergence 2022

    Investigation of Predictive Factors for Active Disease Status Within 24 Months of Juvenile Idiopathic Arthritis Diagnosis

    Erin Balay1 and Susan Shenoi2, 1University of Washington, Seattle Children's Hospital, Seattle, WA, 2Seattle Children's Hospital and Research Center / University of Washington, Seattle, WA

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is the most common rheumatologic disease in children. JIA disease course and prognosis varies significantly between its seven categories, and…
  • Abstract Number: 1148 • ACR Convergence 2022

    GWAS Identified New Genes in Synovial Fibroblasts Linked to Early Remission in RA

    Marc Maurits1, lydia Abasolo Alcazar2, Erik van den Akker3, Johan Askling4, Anne Barton5, Stephan Blüml6, Stephan Böhringer7, Andrew Cope8, Paul Emery9, Stephen Eyre5, Priya Gaddi5, Isidoro Gonzalez10, Carl Goodyear11, Annette van der Helm-van Mil12, Xinli Hu13, Tom Huizinga3, John D Isaacs14, Scott Jelinsky13, Martina Johannesson4, Samantha Jurado Zapata3, Changlin Ke3, Lars Klareskog4, Dennis Lendrem15, Myles Lewis16, Mingdong Liu3, Paul Martin17, Iain B McInnes18, Raphael Micheroli19, Ann Morgan20, Fraser Morton11, Najib Naamane15, Gisela Orozco5, Caroline Ospelt21, Leonid Padyukov4, Caron Paterson11, Darren Plant5, Duncan Porter22, Arthur Pratt23, Soumya Raychaudhuri24, Louise Reynard15, Luis Rodriguez-Rodriguez25, Daniela Sieghart26, Paul Studenic6, John Taylor27, René Toes3, Marloes Verstappen3, Suzanne Verstappen5, Helga Westerlind4, Aaron Winkler13 and Rachel Knevel3, 1LUMC, Leiden, Netherlands, 2IDISSC Hospital Clinico San Carlos, Madrid, Spain, 3Leiden University Medical Center, Leiden, Netherlands, 4Karolinska Institutet, Stockholm, Sweden, 5The University of Manchester, Manchester, United Kingdom, 6Medical University of Vienna, Vienna, Austria, 7Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Leiden, Netherlands, 8King's College London, Surrey, United Kingdom, 9Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 10Hospital Universitario de La Princesa, Madrid, Spain, 11University of Glasgow, Glasgow, Scotland, United Kingdom, 12Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands, 13Pfizer Inc., Cambridge, MA, 14Institute for Translational and Clinical Research, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom, 15Newcastle University, Newcastle, United Kingdom, 16Queen Mary University of London, London, United Kingdom, 17The University of Manchester, Oberhaching, Germany, 18Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom, 19University Hospital Zurich, Department of Rheumatology, Zürich, Switzerland, 20University of Leeds, Leeds, United Kingdom, 21Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 22Gartnavel General Hospital, Bearsden, United Kingdom, 23Newcastle University, Newcastle upon Tyne, United Kingdom, 24Brigham and Women's Hospital, Boston, MA, 25Instituto de Investigación Sanitaria San Carlos, Rheumatology, Madrid, Spain, 26Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 27University of Leeds, Euclid, OH

    Background/Purpose: In order to understand the genetic factors that lead to early remission in RA, we performed a GWAS to uncover important biological pathways.Methods: We…
  • Abstract Number: 1402 • ACR Convergence 2022

    Late Onset Rheumatoid Arthritis Has a Similar Remission Rate as Younger Onset Rheumatoid Arthritis: Results from an Ontario Rheumatoid Arthritis Registry

    Xiuying Li1, Angela Cesta1, Mohammad Movahedi2 and Claire Bombardier3, 1University Health Network, Toronto, ON, Canada, 2Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 3University of Toronto, Toronto, ON, Canada

    Background/Purpose: The prevalence of rheumatoid arthritis (RA) in persons 60 years or older is estimated to be 2%. Late onset rheumatoid arthritis (LORA) is a…
  • Abstract Number: 1545 • ACR Convergence 2022

    Increased Neutrophil Activation in Patients with Polymyalgia Rheumatica

    Despina Michailidou1, Linda Johansson2, Runa Kuley1, TING WANG1, Payton Hermanson1, Solbritt Rantapää-Dahlqvist2 and Christian Lood1, 1Division of Rheumatology, University of Washington, Seattle, WA, 2Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden

    Background/Purpose: Neutrophils are important in host defense. However, neutrophil activation has also been involved in the immunopathogenesis of several autoimmune diseases due to their many…
  • Abstract Number: 1987 • ACR Convergence 2022

    Prednisone Use and the Incidence of Hyperglycemia or Diabetes in Patients with Rheumatoid Arthritis; A 10-year Sub Analysis of the BeSt Study

    CF Allaart1, Sytske Anne Bergstra2, Tom Huizinga1 and Joy van der Pol3, 1Leiden University Medical Center, Leiden, Netherlands, 2LUMC, Leiden, Netherlands, 3Leiden University Medical Center, Utrecht, Netherlands

    Background/Purpose: Use of prednisone in rheumatoid arthritis has been questioned because it may trigger side effects such as hyperglycemia and diabetes. However, disease activity (DAS)…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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