Abstracts tagged "Diagnostic Tests"

Abstract Number: 400 • 2014 ACR/ARHP Annual Meeting
Clinical Utility of 14-3-3η in the Evaluation of Inflammatory Arthritis
Lance Feller¹, Paul Tuttle IV² and Terry L. Moore³, ¹Rheumatology, Saint Louis University, St. Louis, MO, ²Rheumatology, Saint Louis University, Saint Louis, MO, ³Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose 14-3-3 proteins are chaperonins found in all eukaryotic cells. There are multiple isoforms which are thought to be involved in intracellular signaling and transcription…
Abstract Number: 2534 • 2014 ACR/ARHP Annual Meeting
Ocular Surface Temperature in Early Sjogren’s Syndrome and Established Disease
Andreea Coca¹, Ranjini Kottaiyan², Mircea Coca³, Debbie Campbell⁴, Holly Hindman² and James Aquavella², ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Ophtalmology, University of Rochester, Rochester, NY, ³Ophtalmology, University of Texas Medical Branch, Galveston, TX, ⁴Allergy, Immunology and Rheumatology, Univerity of Rochester, Rochester, NY
Background/Purpose Due to a variety of factors it is challenging to make a definite diagnosis in the early stages of Sjögren’s syndrome (SS). The ocular…
Abstract Number: 357 • 2014 ACR/ARHP Annual Meeting
Development and Validation of a Diagnostic Bead-Based Multiplex Autoantibody Assay:Screening for Autoantibodies to Detect “Seronegative” Rheumatoid Arthritis
Stefan Vordenbäumen¹, Angelika Lueking², Carmen Theek², Ralph Brinks¹, Rebecca Fischer-Betz¹, Jutta Richter¹, Ellen Bleck¹, Jacqueline Detert³, Gerd Burmester⁴, Peter Schulz-Knappe² and Matthias Schneider¹, ¹Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, ²Protagen AG, Dortmund, Germany, ³Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ⁴Departement of Rhe, University Medicine, Berlin, Germany
Background/Purpose: Autoantibodies (auto-Ab) against citrullinated peptides (ACPA) and rheumatoid factor (RF) are important biomarkers in the diagnostic process of rheumatoid arthritis (RA). However, RF or…
Abstract Number: 2540 • 2014 ACR/ARHP Annual Meeting
Sjö™, an Advanced Diagnostic Panel for Detection of Sjögren’s Syndrome Autoantibodies
Mark Jasek¹, Kishore Malyavantham², Lakshmanan Suresh³, Julian Ambrus⁴ and Dennis Pardo⁵, ¹Medical and Scientific Affairs, Nicox Inc, Fort Worth, TX, ²Office of Science & Technology, IMMCO Diagnostics Inc., Amherst, NY, ³60 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, ⁴Division of Allergy, Immunology and Rheumatology, Department of Medicine, State University of New York at Buffalo, Buffalo, NY, ⁵Professional Affairs, Nicox Inc, Fort Worth, TX
Background/Purpose Sjögren’s syndrome (SS) is a complex autoimmune disease involving the salivary and lacrimal glands along with various systemic manifestations. It is a difficult disease to…
Abstract Number: 158 • 2014 ACR/ARHP Annual Meeting
Performance of Joint Ultrasonography in the Diagnosis of Suspected Acute Crystal Arthritis : Results of a Prospective Study of 112 Patients
Pascal Zufferey¹, Isabelle Fabreguet¹, Roxana Valcov¹, Alexandre Dumusc¹ and Alexander K. So Sr.², ¹DAL, RHU/CHUV, Lausanne, Switzerland, ²Dal/Rhu, CHUV, Lausanne, Switzerland
Background/Purpose The gold standard for diagnosing gout and CCP arthritis is the identification of monosodium urate (MSU) crystals in joint fluid. Ultrasound (US) features of…
Abstract Number: 2209 • 2014 ACR/ARHP Annual Meeting
Novel Biomarkers of Extracellular Matrix Remodeling in Inflammatory Bowel Disease: Different Patterns of Gut Injury in UC and CD
Joachim Høg Mortensen¹, Line Elberg Godskesen², Michael Dam Jensen², Lone Gabriels Klinge², Jens Kjeldsen², Aleksander Krag², Morten Karsdal³ and Anne C. Bay-Jensen⁴, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Købehavn, Denmark, ²Odense University Hospital, Odense, Denmark, ³Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁴Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark
Background/Purpose: About 10 % of patients with IBD have symptoms that match both Crohn's disease (CD) and ulcerative colitis (UC), termed inflammatory bowel disease unclassified…
Abstract Number: 148 • 2014 ACR/ARHP Annual Meeting
Value of Ultrasonography Parotid Glands in Patients with Suspected Primary Sjögren’s Syndrome
Marina Oliver¹, Lida Santiago², Paula Gonzalez¹, Diego Vila¹, Sebastian fernandez Nacul¹, Santiago Scarafia³, Marta Mamani⁴ and Anastasia Secco³, ¹Rheumatology, Rivadavia Hospital, Buenos Aires, Argentina, ²hospital rivadavia, CABA, Argentina, ³Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁴Hospital Rivadavia, Capital Federal, Argentina
Background/Purpose Primary Sjogren’s syndrome (pSS) is an autoimmune disorder characterised by chronic lymphocytic infiltration of exocrine tissues. Currently new non-invasive techniques are being continuously introduced…
Abstract Number: 2057 • 2014 ACR/ARHP Annual Meeting
Electrophysiological Evaluation of Autonomic Nervous System and Cutaneous Silent Period in Patients with Fibromyalgia Syndrome
Isil Ustun¹, Ilker Yagci², Gulseren Akyuz³ and Feyza Unlu,Ozkan⁴, ¹Physical Medicine and Rehabilitation, Bagcilar Training Hospital, Istanbul, Turkey, ²Marmara Universitesi T?p Fakultesi, Istanbul, Turkey, ³Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey, ⁴Fatih Sultan Mehmet Training Hospital, Istanbul, Turkey
Background/Purpose This study was designed to investigate the autonomic nervous system (ANS) and spinal inhibitory circuits in FMS by electrophysiological studies and compare the results…
Abstract Number: 1578 • 2013 ACR/ARHP Annual Meeting
Decreased Sensitivity Of a Commercial Anti-dsDNA Assay In Patients With Moderately To Severely Active Systemic Lupus Erythematosus
Munther A. Khamashta¹, Gabor G. Illei², Stephen Yoo², Liangwei Wang³ and Warren Greth², ¹Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ²Clinical Development, MedImmune, LLC, Gaithersburg, MD, ³Biostatistics, MedImmune, LLC, Gaithersburg, MD
Background/Purpose: Anti-dsDNA autoantibodies are highly specific for SLE. Anti-dsDNA positivity is an important eligibility criterion in many SLE studies, and decreases in anti-dsDNA levels are…
Abstract Number: 1390 • 2013 ACR/ARHP Annual Meeting
Chaperonin Protein 14-3-3n (eta) In Rheumatoid Arthritis and Arthritogenic Viral Infections
Stanley J. Naides, Olga S Zhukov, Rania W Abolhosn and Joanna M Popov, Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA
Background/Purpose: The 14-3-3 proteins are ubiquitously-expressed intracellular chaperonins. Expression of the η (eta) isoform is restricted to synovial and CNS tissues. Extracellular 14-3-3η induces proinflammatory…
Abstract Number: 1325 • 2013 ACR/ARHP Annual Meeting
A Novel Index To Identify Interstitial Lung Disease In Rheumatoid Arthritis Patients
Jose Felix Restrepo¹, Inmaculada Del Rincon², Roy W. Haas³, Daniel F. Battafarano⁴ and Agustin Escalante⁵, ¹Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ²Rheumatology, University of Texas Health Science Center, San Antonio, TX, ³Dept. of Medicine-Rheumatology, University of Texas Health Science Center, San Antonio, TX, ⁴Medicine / MCHE-MDR, San Antonio Military Medical Center, San Antonio, TX, ⁵Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX
A Novel Index to Identify Interstitial Lung Disease in Rheumatoid Arthritis Patients José Félix Restrepo1, Inmaculada del Rincón1, Roy W Haas1, Daniel F Battafarano2, Agustín Escalante1…
Abstract Number: 1301 • 2013 ACR/ARHP Annual Meeting
The Tumor Necrosis Factor Stimulated Gene-6 Promoter Reporter Can Monitor The Disease Activity In Rheumatoid Arthritis
Mathijs G.A. Broeren¹, Eline A. Vermeij¹, Onno J. Arntz², Miranda B. Bennink¹, Emma Sterken¹, Calin Popa², Tim L. Jansen³, Wim B. van den Berg⁴ and Fons A.J. Van de Loo⁵, ¹Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology, Radboud UMC, Nijmegen, Netherlands, ⁴Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: An important step in the optimal personalized treatment of rheumatoid arthritis (RA) patients, is the accurate assessment of disease activity, disease progression and therapy…
Abstract Number: 1138 • 2013 ACR/ARHP Annual Meeting
Tuberculin Skin Test and Booster Phenomenon In a Rheumatoid Arthritis Population. Differences Between Early and Established Disease
Lorena Perez-Barbosa¹, David Vega-Morales², Janett Carmen Luzmilla Riega-Torres¹, Octavio Ilizaliturri-Guerra¹ and Mario Alberto Garza-Elizondo¹, ¹Early Arthritis Clinic, Rheumatology Service, Hospital Universitario, Monterrey, Mexico, ²Rheumatology, Hospital Universitario UANL, Monterrey, Mexico
Background/Purpose: Tuberculosis (TB) remains a major global health problem. Chronic inflammation in Rheumatoid Arthritis (RA) and the use of immunosuppressive drugs, increase the risk of…
Abstract Number: 671 • 2013 ACR/ARHP Annual Meeting
Autoantibody Diversity In Scleroderma Patients With Antinucleolar Antibodies and Negative For Three Major Disease-Specific Markers
Sarada Nandiwada¹, Troy Jaskowski², Maureen D. Mayes³, Minoru Satoh⁴ and Anne E. Tebo¹, ¹Pathology, University of Utah, Salt Lake City, UT, ²ARUP Laboratories, Salt Lake City, UT, ³University of Texas Health Science Center at Houston, Houston, TX, ⁴Medicine, University of Florida, Gainesville, FL
Background/Purpose: Antinuclear antibodies (ANA) in a nucleolar pattern (antinucleolar antibodies, ANoA) by indirect immunofluorescence technique correlate with several autoantibody specificities and clinical manifestations in scleroderma…
Abstract Number: 639 • 2013 ACR/ARHP Annual Meeting
Examination Of The Cytokine Profile Of The Cerebrospinal Fluid In Neuropsychiatric Systemic Lupus Erythematosus
Kunihiro Ichinose¹, Takeshi Ushigusa², Yoshikazu Nakashima³, Takahisa Suzuki³, Yoshiro Horai⁴, Shin-ya Kawashiri², Naoki Iwamoto², Mami Tamai³, Kazuhiko Arima⁴, Hideki Nakamura², Tomoki Origuchi⁵ and Atsushi Kawakami⁴, ¹Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Examination of the cytokine profile of the cerebrospinal fluid in neuropsychiatric systemic lupus erythematosusBackground/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication in systemic…

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