Abstracts tagged "depression"

Abstract Number: 0434 • ACR Convergence 2020
Changes in Mental Health During the COVID-19 Pandemic Among Individuals with Rheumatic Disease
Patricia Katz¹, Sofia Pedro², Kristin Wipfler³, Teresa Simon⁴, Yomei Shaw⁵, Adam Cornish⁶ and Kaleb Michaud⁷, ¹University of California, San Francisco, Novato, CA, ²FORWARD-The National Data Bank for Rheumatic Diseases, Wichita, ³FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ⁴Bristol-Myers Squibb Company (at time of analysis), Princeton, NJ, ⁵Forward, The National Databank for Rheumatic Diseases, East Lansing, MI, ⁶FORWARD, 68134, NE, ⁷University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Symptoms of both depression and anxiety are often elevated among individuals with rheumatic conditions, and stress levels may play a role in each. Depression,…
Abstract Number: 1804 • ACR Convergence 2020
Impact of the Kynurenine/Tryptophan Pathway on Cognitive Dysfunction and Depression in Systemic Lupus Erythematosus
Erik Anderson¹, Joanna Fishbein², Joseph Hong², Julien Roeser³, Richard Furie⁴, Cynthia Aranow², Bruce Volpe², Betty Diamond⁵ and Meggan Mackay⁶, ¹Feinstein Institutes for Medical Research, New York, NY, ²Feinstein Institutes for Medical Research, Manhasset, NY, ³Charles River Laboratories, South San Francisco, CA, ⁴Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, ⁵Northwell Health, Manhasset, NY, ⁶Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Tryptophan (TRP) is metabolized to kynurenine (KYN), quinolonic acid [QA, a N-methyl D-aspartate receptor (NMDAR) agonist] and kynurenic acid (KA, an NMDAR antagonist). KYN/TRP…
Abstract Number: 0547 • ACR Convergence 2020
Transgender Patients in the Rheumatology Setting
Chantelle Carneiro¹, Jessica Chee², Karen Beattie² and Kimberly Legault², ¹McMaster University, Toronto, ON, Canada, ²McMaster University, Hamilton, ON, Canada
Background/Purpose: Minimal medical research exists regarding transgender patients, particularly within the field of rheumatology. A few case reports note that male to female transitions may…
Abstract Number: 1806 • ACR Convergence 2020
The Association of Interferon-α with Kynurenine/Tryptophan Pathway Activation in Systemic Lupus Erythematosus
Erik Anderson¹, Ying Jin², Sara Goodwin², Julien Roeser³, Richard Furie⁴, Cynthia Aranow⁵, Bruce Volpe⁵, Betty Diamond⁶ and Meggan Mackay⁷, ¹Feinstein Institutes for Medical Research, New York, NY, ²Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, ³Charles River Laboratories, South San Francisco, CA, ⁴Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, ⁵Feinstein Institutes for Medical Research, Manhasset, NY, ⁶Northwell Health, Manhasset, NY, ⁷Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Type I IFN contributes to SLE pathogenesis and stimulates the kynurenine/tryptophan (KYN/TRP) pathway, producing elevated quinolinic acid (QA) levels relative to kynurenic acid (KA)…
Abstract Number: 0551 • ACR Convergence 2020
Physical Performance as a Mediator of the Association Between Depression and Pain in Knee Osteoarthritis
Alan Rathbun¹, Elizabeth Stuart², Michelle Shardell¹, Trang Nguyen², Alice Ryan¹, Joseph Gallo², Michelle Yau³, Megan Schuler⁴ and Marc Hochberg¹, ¹University of Maryland School of Medicine, Baltimore, MD, ²Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ³Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, ⁴RAND Corporation, Boston, MA
Background/Purpose: Depression is common in knee osteoarthritis (OA), and leads to reduced physical function, which may mediate the effect of depression on pain. However, research…
Abstract Number: 1943 • ACR Convergence 2020
The Prevalence of Anxiety and Depression in Patients with Giant Cell Arteritis
Joana Martinho¹, André Ponte², Eduardo Dourado³, Nikita Khmelinskii¹, Sara Dias⁴, Sofia Barreira⁵, Ana Rita Cruz-Machado¹, Carla Macieira¹, Vítor Teixeira⁶, Ana Rodrigues⁴, Diogo Telles-Correia⁷, João Eurico Fonseca⁸ and Cristina Ponte¹, ¹Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal, ²Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal, Lisbon, Portugal, ³Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Lisboa, Portugal, ⁴EpiDoC Unit, Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School, Universidade NOVA de Lisboa (NMS/UNL), Lisbon, Portugal, ⁵Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal, ⁶Rheumatology Department, Centro Hospitalar Universitário do Algarve, Faro, Portugal, ⁷Serviço de Psiquiatria, Hospital de Santa Maria, CHULN, Lisboa, Portugal, Lisbon, Portugal, ⁸Instituto de Medicina Molecular, Faculdade Medicina Universidade de Lisboa and Centro Hospitalar Universitário Lisboa Norte., Lisboa, Portugal
Background/Purpose: Giant cell arteritis (GCA) is the most common primary vasculitis of the elderly causing blindness if left untreated. However, its hallmark treatment with glucocorticoids…
Abstract Number: 0609 • ACR Convergence 2020
Impact of Depressive Symptoms, Anti-depression Treatment on Direct Medical Costs Among Medicare Beneficiaries with Knee Osteoarthritis (KOA)
Shuang Song¹, Jeffrey Katz² and Elena Losina², ¹Brigham and Women's Hospital, Brighton, MA, ²Harvard Medical School / The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA
Background/Purpose: Depressive symptoms are prevalent among knee OA (KOA) patients and likely lead to additional medical costs. We sought to quantify the prevalence of depressive…
Abstract Number: 1947 • ACR Convergence 2020
Risk Factors for Anxiety and Depression in Patients with Giant Cell Arteritis
Joana Martinho¹, André Ponte², Eduardo Dourado³, Nikita Khmelinskii¹, Sara Dias⁴, Sofia Barreira⁵, Ana Rita Cruz-Machado¹, Carla Macieira¹, Vítor Teixeira⁶, Ana Rodrigues⁴, Diogo Telles-Correia⁷, João Eurico Fonseca⁸ and Cristina Ponte¹, ¹Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal, ²Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal, Lisbon, Portugal, ³Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Lisboa, Portugal, ⁴EpiDoC Unit, Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School, Universidade NOVA de Lisboa (NMS/UNL), Lisbon, Portugal, ⁵Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal, ⁶Rheumatology Department, Centro Hospitalar Universitário do Algarve, Faro, Portugal, ⁷Serviço de Psiquiatria, Hospital de Santa Maria, CHULN, Lisboa, Portugal, Lisbon, Portugal, ⁸Instituto de Medicina Molecular, Faculdade Medicina Universidade de Lisboa and Centro Hospitalar Universitário Lisboa Norte., Lisboa, Portugal
Background/Purpose: Giant cell arteritis (GCA) is the most common primary vasculitis affecting patients aged above 50 years. Its clinical manifestations such as headache, jaw claudication…
Abstract Number: 0618 • ACR Convergence 2020
The Effect of Travel Burden on Depression and Anxiety in African American Women Living with Systemic Lupus
Trevor Faith¹, Ashley White¹, Aissatou Ba¹, Viswanathan Ramakrishnan², Hetlena Johnson³, Jillian Rose⁴, Clara Dismuke-Greer⁵, Jim Oates⁶, Leonard Egede⁷ and Edith Williams¹, ¹Medical University of South Carolina, Charleston, SC, ²medical university of south carolina, south carolina, ³LupusCSC, Columbia, SC, ⁴Hospital for Special Surgery, New York, ⁵Palo Alto VA, Palo Alto, CA, ⁶Medical University of South Carolina, Charleston, SC, Charleston, SC, ⁷Medical College of Wisconsin, Milwaukee, WI
Background/Purpose: The United States has a deficit of rheumatology specialists. This leads to an increased burden accessing care for patients with autoimmune and connective tissue…
Abstract Number: 1967 • ACR Convergence 2020
Combating Rheumatologist Burnout: Use of Protocol Driven Medication Refill by Pharmacists
Eva Rottmann¹, Jonida Cote², Swana Thomas³, Dante Grassi¹, Joseph Chronowski¹, Lisa L. Schroeder¹, David Pugliese⁴ and Eric Newman¹, ¹Geisinger Medical Center, Danville, PA, ²Geisinger Medical Center, Danvile, PA, ³Geisinger Medical Center, Wilkes-Barre, PA, ⁴Geisinger Health System, Wilkes Barre, PA
Background/Purpose: Increased electronic health record (EHR) administrative workload is a great source of physician dissatisfaction. We embedded pharmacists into our Rheumatology team in 2019. This…
Abstract Number: 0724 • ACR Convergence 2020
Anxiety and Depressive Symptoms in Juvenile Idiopathic Arthritis (JIA) Correlate with Pain and Stress Using Patient-Reported Outcomes Measurement Information System (PROMIS®)
Danielle Fair¹, Judyann Olson², Jan Lemke¹, Stella Protopapas³, Ke Yan² and Jian Zhang², ¹Children's Wisconsin, Milwaukee, WI, ²Medical College of Wisconsin, Milwaukee, WI, ³Riley Children's Hospital at Indiana University, Indianapolis, IN
Background/Purpose: Children with chronic diseases have higher rates of mental health issues and less favorable outcomes than the general pediatric population. Children with JIA experience…
Abstract Number: 0854 • ACR Convergence 2020
Mortality and Adverse Events of Special Interest in Adult Patients with Systemic Lupus Erythematosus Receiving Intravenous Belimumab: A Post Hoc Descriptive Summary of Serious Psychiatric Events
Saira Sheikh¹, Ricardo Acayaba de Toledo², Laura Geraldino-Pardilla³, Julia Harris⁴, Regina Kurrasch⁵, Andrew Liu⁴, Kathleen Maksimowicz-McKinnon⁶, Holly Quasny⁷, David Roth⁵, Lilian Soto⁸ and Rajesh Punwaney⁵, ¹University of North Carolina Thurston Arthritis Research Center, Chapel Hill, ²Faculdade de Medicina de São José do Rio Preto, São Paulo, Brazil, ³Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, ⁴GlaxoSmithKline, Uxbridge, United Kingdom, ⁵GlaxoSmithKline, Collegeville, ⁶Henry Ford Hospital, Detroit, ⁷GlaxoSmithKline, Research Triangle Park, ⁸Facultad de Medicina, Clinical Hospital of Universidad de Chile, Santiago, Chile
Background/Purpose: Intravenous (IV) belimumab (BEL) is approved in patients ≥5 years of age with active systemic lupus erythematosus (SLE). Results of the BASE study (the…
Abstract Number: 1260 • ACR Convergence 2020
Longitudinal Relationships Between Depression, Anxiety and Cognition in Lupus
Kathleen Bingham¹, Juan Pablo Diaz-Martinez², Mahta Kakvan², Robin Green³, Dorcas Beaton⁴, Lesley Ruttan³, Carmela Tartaglia⁵, Marvin Fritzler⁶, May Choi⁷, Jiandong Su², Denisse Bonilla⁸, Nicole Anderson², Joan Wither², Patricia Katz⁹ and Zahi Touma¹⁰, ¹Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ²University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ³Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada, ⁴Institute for Work & Health, Toronto, ON, Canada, ⁵University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, ⁶Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁷Brigham and Women's Hospital | Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁸University Health Network, Toronto, Canada, ⁹University of California, San Francisco, Novato, CA, ¹⁰University of Toronto, Toronto, ON, Canada
Background/Purpose: There is a consistent relationship between cognition and depression and anxiety (affective symptoms) in lupus. Together, affective and cognitive symptoms represent among lupus’ most…
Abstract Number: 1289 • ACR Convergence 2020
Sex Differences in Mental Health and Quality of Life and Their Impact in the Treatment of Patients with Systemic Lupus Erythematosus
Lilian Cano-Cruz¹, Eduardo Aguirre-Aguilar¹, Martín Valdez-López², Ana Barrera-Vargas¹, Virginia Pascual Ramos¹ and Javier Merayo-Chalico³, ¹INSTITUTO NACIONAL DE CIENCIAS MEDICAS Y NUTRICION SALVADOR ZUBIRAN, Mexico City, Distrito Federal, Mexico, ²INSTITUTO NACIONAL DE CIENCIAS MEDICAS Y NUTRICION SALVADOR ZUBIRAN, Mexico City, Mexico, ³INSTITUTO NACIONAL DE CIENCIAS MEDICAS Y NUTRICION SALVADOR ZUBIRAN, Ciudad de Mexico, Distrito Federal, Mexico
Background/Purpose: Systemic lupus erythematosus (SLE) predominantly affects young women. It is usually more aggressive in men and carries a worse prognosis. Information about gender differences…
Abstract Number: 1291 • ACR Convergence 2020
Depressed Symptomatology Persists over Time in the Majority of Systemic Lupus Erythematosus Patients and Is Independent of Disease Activity
Sara Kellahan¹, Xinliang Huang¹, Daphne Lew², Hong Xian³, Seth Eisen¹ and Alfred Kim⁴, ¹Division of Rheumatology, Washington University in St. Louis School of Medicine, St. Louis, ²Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, ³Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, St. Louis, ⁴Washington University School of Medicine, St. Louis, MO
Background/Purpose: Depression is a prevalent (24-30%) and significant comorbidity in patients with systemic lupus erythematosus (SLE) (1). As the American College of Rheumatology (ACR) classifies…

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