Abstracts tagged "Dendritic cells"

Abstract Number: 2170 • 2014 ACR/ARHP Annual Meeting
Human Tolerogenic Dendritic Cells Generated with Protein Kinase C Inhibitor Are Optimal for Regulatory T Cell Induction-a Comparative Study
Endy Adnan¹, Hitoshi Hasegawa², Takuya Matsumoto¹, Jun Ishizaki¹, Sachiko Onishi¹, Koichiro Suemori¹ and Masaki Yasukawa¹, ¹Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan, ²Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan
Background/Purpose Tolerogenic dendritic cells (tDCs) are a promising tool for autoimmune diseases, transplantation and allergy. Actually, tDCs have been tried for the therapy of rheumatoid…
Abstract Number: 1530 • 2014 ACR/ARHP Annual Meeting
Autologous Tolerogenic Dendritic Cells for Rheumatoid and Inflammatory Arthritis
Gillian Bell¹, Amy E. Anderson¹, Julie Diboll¹, Rachel Harry¹, Elaine McColl², Anne Dickinson³, Catharien Hilkens¹ and John D Isaacs¹, ¹Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ²Clinical Trials Unit, Institute of Health and Society, NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ³Institute of Cellular Medicine (Haematological Sciences), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom
Background/Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease which results from a breakdown of immune tolerance. Despite their efficacy current RA therapeutics, including biologic…
Abstract Number: 1137 • 2014 ACR/ARHP Annual Meeting
Multiway Transcriptomic Analysis of Monocyte-Derived Dendritic Cells Discriminates Effects of Disease and of HLA-B27 in Spondyloarthritis
Emmanuel Chaplais¹, Alice Talpin², Félicie Costantino¹, Clémence Desjardin¹, Nelly Bonilla², Ariane Leboime³, Roula Said Nahal⁴, Franck Letourneur², Jacques Sébastien², Gilles Chiocchia⁵, Maxime Breban¹ and Henri-Jean Garchon¹, ¹INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, ²INSERM U1016, Cochin Institute, Paris, France, ³Rheumatology Division, Ambroise-Paré Hospital AP-HP, Boulogne-Billancourt, France, ⁴Service de Rhumatologie, Hopital Ambroise Pare, Boulogne-Billancourt, France, ⁵Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France
Background/Purpose Spondyloarthritis (SpA) etiology is largely multifactorial with a genetic component dominated by the long-known strong association with the HLA-B27 allele. This allele, however, is…
Abstract Number: 950 • 2014 ACR/ARHP Annual Meeting
Multiple Mechanisms of Tolerance Characterize the Immune Response to Autologous Modified Dendritic Cells Exposed to Citrullinated Peptides in Patients with Rheumatoid Arthritis
Soi-Cheng Law¹, Hendrik Nel², Ahmed Mehdi², Kim-Anh Le Cao² and Ranjeny Thomas³, ¹Diamantina Institute, Univ of Queensland, Brisbane, Australia, ²Diamantina Institute, University of Queensland, Brisbane, Australia, ³Diamantina Institute, Univ of Queensland, Brisbane, QLD, Australia
Background/Purpose We carried out a phase I clinical trial of tolerising autologous peripheral blood DCs exposed to 4 citrullinated self-peptides (“Rheumavax”) in 29 HLA-DR shared…
Abstract Number: 946 • 2014 ACR/ARHP Annual Meeting
Phase 1 Study of Immunotherapy Using Autoantigen-Loaded Dendritic Cells in Patients with Anti-Citrullinated Peptide Antigen Positive Rheumatoid Arthritis
Young Bin Joo¹, Jun-Eui Park², Chan-Bum Choi³, Jeongim Choi¹, Jin-ah Jang², Minkyu Heo², Hak-yeop Kim², Hye-Soon Lee⁴, Yong-Soo Bae⁵ and Sang-Cheol Bae¹, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²JW CreaGene Research Institute, JWCreaGene Inc., Seongnam-si, South Korea, ³Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ⁴1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁵3Department of Biological Science, Sungkyunkwan University, Suwon, South Korea
Background/Purpose To date, no dendritic cell (DC) immunotherapy has been shown to give a benefit in patients with rheumatoid arthritis (RA). In this prospective phase…
Abstract Number: 767 • 2014 ACR/ARHP Annual Meeting
The Impact of Plasmacytoid Dendiritc Cells (pDCs) on Fibrosis in bleomycin–induced Murine Model of Systemic Sclerosis (SSc)
Suzanne Kafaja¹, Isela Valera¹, Anagha Divekar², Daniel E. Furst³ and Ram Singh¹, ¹Medicine/Rheumatology, University of California, Los Angeles, Los Angeles, CA, ²Biolegend, San Diego, CA, ³Medicine/ Rheumatology, University of California, Los Angeles, Department of Medicine, Los Angeles, CA
Background/Purpose Pathogenesis of systemic sclerosis (SSc) remains unclear. Alterations in adaptive and innate immune responses, with increased T-cells that produce type 2 cytokines and impaired…
Abstract Number: 642 • 2014 ACR/ARHP Annual Meeting
Treatment with a Glycolipid Ameliorates Lupus Dermatitis and Expands Skin ãä T Cells That Promote the Migration of Langerhans Dendritic Cells
Ram Raj Singh^1,2,3, Anna Eriksson¹, Darshan Randhawa¹ and Miguel-Angel Gutierrez¹, ¹Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, ²Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, ³Interdepartmental Program in Molecular Toxicology, UCLA, Los Angeles, CA
Background/Purpose: Self antigens are taken from tissues to local lymphoid organs to acquire ability to avoid self-reactivity. This important immune function is accomplished by dendritic…
Abstract Number: 1616 • 2013 ACR/ARHP Annual Meeting
Interferon Regulatory Factors 3 and 5 As Key Elements Of The Interferon Signature On Plasmacytoid Dendritic Cells From Systemic Lupus Erythematosus Patients
Diana Gómez-Martín¹, Karina Santana-de Anda², Adriana Elizabeth Monsivais-Urenda³, Sandra Rajme-Lopez⁴, Luis Aparicio-Vera⁴, Jorge Alcocer-Varela¹ and Roberto González-Amaro³, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico, ³Department of Immunology, Facultad de Medicina. UASLP, San Luis Potosí, Mexico, ⁴Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico
Background/Purpose: Plasmacytoid dendritic cells (pDC) are considered the main source of type-I interferon (IFN-I). The interferon signature has been widely associated to systemic lupus erythematosus…
Abstract Number: 1170 • 2013 ACR/ARHP Annual Meeting
Expression and Function Of Human Mfg-E8 In The Clearance Of Apoptotic Cells and Suppression Of Inflammation
Lucrezia Colonna¹, Jie An², Xizhang Sun³, Nalini Agrawal⁴, Alice Wiedeman⁵ and Keith B. Elkon³, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, Department of Medicine & Immunology, University of Washington, Seattle, WA, ³Division of Rheumatology, University of Washington, Seattle, WA, ⁴Rheumatology, University of Washington, Seattle, WA, ⁵Immunology, University of Washington, Seattle, WA
Background/Purpose: Effective clearance of apoptotic cells (AC) is necessary for the maintenance of tolerance to self. MFG-E8 is one of ~20 different opsonins reported to…
Abstract Number: 1145 • 2013 ACR/ARHP Annual Meeting
Regulation Of Plasmacytoid Dendritic Cells By Prostaglandin E2
Alice E. Wiedeman¹ and Keith B. Elkon², ¹Immunology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Plasmacytoid dendritic cells (pDCs) constitute a rare blood cell subset exquisitely attuned for production of large quantities of interferon-alpha (IFN-α), and these cells have…
Abstract Number: 1148 • 2013 ACR/ARHP Annual Meeting
Autologous Tolerogenic Dendritic Cells In Rheumatoid and Inflammatory Arthritis
Gillian Bell¹, Amy Anderson², Julie Diboll¹, Rachel Harry², Elaine McColl³, Anne Dickinson⁴, Catharien Hilkens¹ and John Isaacs⁵, ¹Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ²Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ³Clinical Trials Unit, Institute of Health and Society, NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ⁴Haematological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ⁵National Institute for Health Research, Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom
Background/Purpose: Rheumatoid arthritis is a chronic autoimmune disease which results from a breakdown of immune tolerance. Current therapies include traditional DMARDs, anti-TNF, B cell depleting…
Abstract Number: 573 • 2013 ACR/ARHP Annual Meeting
Absence Of Estrogen Receptor Alpha Reduces The Number and Function Of Bone Marrow Derived Plasmacytoid Dendritic Cells In Lupus Prone Mice
Jennifer Scott¹, Osama S. Naga², Melissa A. Cunningham³, Jena Wirth³, Jackie G. Eudaly² and Gary S. Gilkeson⁴, ¹Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, ²Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ³Med/Rheumatology, MUSC, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects women at a 9:1 ratio compared to men. Previous work in our laboratory…
Abstract Number: L2 • 2013 ACR/ARHP Annual Meeting
Proteome-Wide Analysis and CXCL4 As a Pathogenic Biomarker in Systemic Sclerosis
Timothy Radstake¹, Lenny van Bon², Alsya Affandi¹, Jasper Broen³, Romy Christmann⁴, Lukasz Stawski⁵, Giuseppina Farina⁶, Allison Mathes⁷, Marta Cossu⁸, MArk Wenink⁹, Roger Hesselstrand¹⁰, Tore Saxne¹¹, Dirk Wuttge¹⁰, John D. Reveille¹², Shervin Assassi¹², Maureen D. Mayes¹³, Wim B van den Berg¹⁴, Vanessa Smith¹⁵, Filip De Keyser¹⁵, Claudio Lunardi¹⁶, Piet L.C. Van Riel¹⁷, Madelon C. Vonk¹⁸, Lorenzo Beretta¹⁹, Maria Trojanowska²⁰ and Robert Lafyatis⁴, ¹Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht/Radboud University Nijmegen Medical Center, Utrecht/Nijmegen, Netherlands, ³Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Rheumatology, Boston Medical Center, Boston, MA, ⁶Arthritis center, Boston University, Boston, MA, ⁷rheumatology, Boston Medical Center, boston, MA, ⁸Rheumatology and Clinical Immunology, University Medical Center Utrecht, utrecht, Netherlands, ⁹rheumatology and Clinical Immunology, university Medical Center Utrecht, utrecht, Netherlands, ¹⁰Rheumatology, Lund University, Lund, Sweden, ¹¹Section of Rheumatology, Deparment of Clinical Sciences, Lund, Lund University, Lund, Sweden, ¹²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹³University of Texas Health Science Center at Houston, Houston, TX, ¹⁴Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ¹⁵Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ¹⁶Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹⁷Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁸Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁹Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²⁰Arthritis Center, Boston University, Boston, MA
Background/Purpose: We hypothesized that plasmacytoid dendritic cells are implicated in the pathogenesis of systemic sclerosis via mechanisms beyond previously suggested type I interferon production. Methods:…
Abstract Number: 2895 • 2013 ACR/ARHP Annual Meeting
Bacterial Amyloids Promote Type I Interferon Production and Accelerate Autoimmunity
Paul Gallo, Glenn Rapsinski, Cagla Tukel and Stefania Gallucci, Dept. of Microbiology and Immunology, Laboratory of Dendritic Cell Biology, Temple Autoimmunity Center, Temple University School of Medicine, Philadelphia, PA
Background/Purpose: Infection is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). This is largely due to the use of…
Abstract Number: 2823 • 2013 ACR/ARHP Annual Meeting
FLIP Deficiency In Dendritic Cells Promotes Spontaneous Inflammatory and Erosive Arthritis
Qi Quan Huang¹, Harris R. Perlman², Robert Birkett³, Renee E. Koessler¹, Syamal K. Datta⁴ and Richard M. Pope⁵, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ⁴Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: FLIP is an anti-apoptotic protein induced by chronic inflammation. In this study a mouse line with FLIP deleted in CD11c+ dendritic cells (DCs), that…

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