ACR Meeting Abstracts

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Abstracts tagged "Dendritic cells"

  • Abstract Number: 2895 • 2013 ACR/ARHP Annual Meeting

    Bacterial Amyloids Promote Type I Interferon Production and Accelerate Autoimmunity

    Paul Gallo, Glenn Rapsinski, Cagla Tukel and Stefania Gallucci, Dept. of Microbiology and Immunology, Laboratory of Dendritic Cell Biology, Temple Autoimmunity Center, Temple University School of Medicine, Philadelphia, PA

    Background/Purpose: Infection is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE).  This is largely due to the use of…
  • Abstract Number: 2823 • 2013 ACR/ARHP Annual Meeting

    FLIP Deficiency In Dendritic Cells Promotes Spontaneous Inflammatory and Erosive Arthritis

    Qi Quan Huang1, Harris R. Perlman2, Robert Birkett3, Renee E. Koessler1, Syamal K. Datta4 and Richard M. Pope5, 1Medicine/Rheumatology, Northwestern University, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, 4Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL

    Background/Purpose: FLIP is an anti-apoptotic protein induced by chronic inflammation.  In this study a mouse line with FLIP deleted in CD11c+ dendritic cells (DCs), that…
  • Abstract Number: 2774 • 2013 ACR/ARHP Annual Meeting

    Distinct Role Of Plasmacytoid Dendritic Cells and Mast Cells In The Pathogenesis Of Sjӧgren’s Syndrome

    Jidong Zhao1, Kunihiro Yamaoka1, Satoshi Kubo1, Shingo Nakayamada2 and Yoshiya Tanaka1, 1The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 2First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan

    Background/Purpose: Sjögren’s Syndrome (SS) is characterized by the destruction of the lacrimal and salivary grands due to autoreactive lymphocyte infiltration in the early phase and…
  • Abstract Number: 2220 • 2013 ACR/ARHP Annual Meeting

    The Role Of CD11c+ Dendritic Cells In Inflammatory Arthritis

    Antonia Puchner1, Stephan Blüml1, Victoria Saferding2, Harald Leiss1, Josef S. Smolen3 and Kurt Redlich4, 1Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Rheumatology, Medical University of Vienna, Vienna, Austria, 3Medical University of Vienna, Vienna, Austria, 4Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Dendritic cells (DCs) play an important role in bridging the innate and the adaptive immune response by serving as antigen presenting cells and are…
  • Abstract Number: 1616 • 2013 ACR/ARHP Annual Meeting

    Interferon Regulatory Factors 3 and 5 As Key Elements Of The Interferon Signature On Plasmacytoid Dendritic Cells From Systemic Lupus Erythematosus Patients

    Diana Gómez-Martín1, Karina Santana-de Anda2, Adriana Elizabeth Monsivais-Urenda3, Sandra Rajme-Lopez4, Luis Aparicio-Vera4, Jorge Alcocer-Varela1 and Roberto González-Amaro3, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico, 3Department of Immunology, Facultad de Medicina. UASLP, San Luis Potosí, Mexico, 4Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico

    Background/Purpose: Plasmacytoid dendritic cells (pDC) are considered the main source of type-I interferon (IFN-I). The interferon signature has been widely associated to systemic lupus erythematosus…
  • Abstract Number: 1170 • 2013 ACR/ARHP Annual Meeting

    Expression and Function Of Human Mfg-E8 In The Clearance Of Apoptotic Cells and Suppression Of Inflammation

    Lucrezia Colonna1, Jie An2, Xizhang Sun3, Nalini Agrawal4, Alice Wiedeman5 and Keith B. Elkon3, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Division of Rheumatology, Department of Medicine & Immunology, University of Washington, Seattle, WA, 3Division of Rheumatology, University of Washington, Seattle, WA, 4Rheumatology, University of Washington, Seattle, WA, 5Immunology, University of Washington, Seattle, WA

    Background/Purpose: Effective clearance of apoptotic cells (AC) is necessary for the maintenance of tolerance to self. MFG-E8 is one of ~20 different opsonins reported to…
  • Abstract Number: 1145 • 2013 ACR/ARHP Annual Meeting

    Regulation Of Plasmacytoid Dendritic Cells By Prostaglandin E2

    Alice E. Wiedeman1 and Keith B. Elkon2, 1Immunology, University of Washington, Seattle, WA, 2Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Plasmacytoid dendritic cells (pDCs) constitute a rare blood cell subset exquisitely attuned for production of large quantities of interferon-alpha (IFN-α), and these cells have…
  • Abstract Number: 1148 • 2013 ACR/ARHP Annual Meeting

    Autologous Tolerogenic Dendritic Cells In Rheumatoid and Inflammatory Arthritis

    Gillian Bell1, Amy Anderson2, Julie Diboll1, Rachel Harry2, Elaine McColl3, Anne Dickinson4, Catharien Hilkens1 and John Isaacs5, 1Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, 2Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 3Clinical Trials Unit, Institute of Health and Society, NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, 4Haematological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 5National Institute for Health Research, Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom

    Background/Purpose: Rheumatoid arthritis is a chronic autoimmune disease which results from a breakdown of immune tolerance. Current therapies include traditional DMARDs, anti-TNF, B cell depleting…
  • Abstract Number: 2271 • 2012 ACR/ARHP Annual Meeting

    Variation of Interferon-Alpha Production in Healthy Individuals and Association with Autoimmune Susceptibility Genes

    Olof Berggren1, Andrei Alexsson2, Gunnar V. Alm3, Ann-Christine Syvänen4, Lars Rönnblom2 and Maija-Leena Eloranta2, 1Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 2Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, 3Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden, 4Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala, Sweden

    Background/Purpose: Many autoimmune diseases, e.g. systemic lupus erythematosus (SLE), have an activated type I interferon (IFN) system and about 40 SLE susceptibility loci, many within…
  • Abstract Number: 2273 • 2012 ACR/ARHP Annual Meeting

    Functional Genetic Polymorphisms in Immunoglobulin-Like Transcript 3 Are Associated with Decreased Surface Expression On Dendritic Cells and Increased Serum Cytokines in Lupus Patients

    Mark A. Jensen, Karen C. Patterson, Akaash A. Kumar, Marissa Kumabe, Beverly S. Franek and Timothy B. Niewold, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL

    Background/Purpose: Hyperactivity of the type I interferon (IFN) pathway is involved in the pathogenesis of systemic lupus erythematosus (SLE). Immunoglobulin like transcript (ILT3) is an…
  • Abstract Number: 2073 • 2012 ACR/ARHP Annual Meeting

    Green Tea Epigallocatechin-3-Gallate Ameliorates Murine Arthritis by Inducing IDO Producing Dendritic Cells Via Nrf2 Antioxidant Pathway

    Soyoun Min1, Mei Yan1, Kamala Vanarsa2, Anna Bashmakov1 and Chandra Mohan1, 1Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, 2Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: To examine the immunomodulatory effects and mechanisms of Green Tea (−)-epigallocatechin-3-gallate (EGCG) on experimental arthritis in mice, we investigated whether EGCG can afford therapeutic…
  • Abstract Number: 1076 • 2012 ACR/ARHP Annual Meeting

    FLIP in Dendritic Cells May Regulate Hematopoietic Homeostasis and Modulating Inflammation and Immunity

    Qi Quan Huang1, Robert Birkett2, Harris R. Perlman3 and Richard M. Pope4, 1Medicine/Rheumatology, Northwestern University, Chicago, IL, 2Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Feinberg School of Medicine, Northwestern University, Chicago, IL, 4Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL

    Background/Purpose: We previously demonstrated that FLIP in myeloid linage cells is necessary for neutrophil homeostasis and macrophage differentiation.  Therefore studies were performed to determine the…
  • Abstract Number: 1079 • 2012 ACR/ARHP Annual Meeting

    Polyclonal CD4+Foxp3+ treg Cells Induce TGFb-Dependent Tolerogenic Dendritic Cells That Suppress Murine Lupus-Like Syndrome

    Qin Lan1 and Song G. Zheng2, 1Medicine, University of Southern California, Los Angeles, CA, 2Medicine, Keck School of Medicine of USC, Los Angeles, CA

    Background/Purpose: Interplay between Foxp3+ regulatory T cells (Treg) and dendritic cells (DCs) maintains immunologic tolerance, but the effects of each cell on the other are…
  • Abstract Number: 1055 • 2012 ACR/ARHP Annual Meeting

    Sec61 Is Indispensable for Antigen Cross-Presentation and the Development of Lupus Nephritis: A Novel ‘Self-Organized Criticality Theory’ Explaining the Cause of Systemic Lupus Erythematosus (SLE)

    Ken Tsumiyama and Shunichi Shiozawa, Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan

    Background/Purpose:  We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
  • Abstract Number: 327 • 2012 ACR/ARHP Annual Meeting

    Tolerogenic Dendritic Cells Ameliorates the Disease Severity of Murine Collagen-Induced Arthritis

    Bin Ning1, Shang-You Yang2, Jianlu Wei1, Weiming Gong1 and Paul H. Wooley2, 1Orthopaedic Surgery, Shandong University Jinan Central Hospital, Jinan, China, 2Orthopaedic Research Institute, Via Christi Wichita Hospitals, Wichita, KS

    Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by synovial inflammation, cartilage breakdown and bone destruction with the involvement of various types of…
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