Abstracts tagged "Dendritic cells"

Abstract Number: 2774 • 2013 ACR/ARHP Annual Meeting
Distinct Role Of Plasmacytoid Dendritic Cells and Mast Cells In The Pathogenesis Of Sjӧgren’s Syndrome
Jidong Zhao¹, Kunihiro Yamaoka¹, Satoshi Kubo¹, Shingo Nakayamada² and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Sjögren’s Syndrome (SS) is characterized by the destruction of the lacrimal and salivary grands due to autoreactive lymphocyte infiltration in the early phase and…
Abstract Number: 2220 • 2013 ACR/ARHP Annual Meeting
The Role Of CD11c+ Dendritic Cells In Inflammatory Arthritis
Antonia Puchner¹, Stephan Blüml¹, Victoria Saferding², Harald Leiss¹, Josef S. Smolen³ and Kurt Redlich⁴, ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Dendritic cells (DCs) play an important role in bridging the innate and the adaptive immune response by serving as antigen presenting cells and are…
Abstract Number: 1616 • 2013 ACR/ARHP Annual Meeting
Interferon Regulatory Factors 3 and 5 As Key Elements Of The Interferon Signature On Plasmacytoid Dendritic Cells From Systemic Lupus Erythematosus Patients
Diana Gómez-Martín¹, Karina Santana-de Anda², Adriana Elizabeth Monsivais-Urenda³, Sandra Rajme-Lopez⁴, Luis Aparicio-Vera⁴, Jorge Alcocer-Varela¹ and Roberto González-Amaro³, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico, ³Department of Immunology, Facultad de Medicina. UASLP, San Luis Potosí, Mexico, ⁴Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico
Background/Purpose: Plasmacytoid dendritic cells (pDC) are considered the main source of type-I interferon (IFN-I). The interferon signature has been widely associated to systemic lupus erythematosus…
Abstract Number: 1170 • 2013 ACR/ARHP Annual Meeting
Expression and Function Of Human Mfg-E8 In The Clearance Of Apoptotic Cells and Suppression Of Inflammation
Lucrezia Colonna¹, Jie An², Xizhang Sun³, Nalini Agrawal⁴, Alice Wiedeman⁵ and Keith B. Elkon³, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, Department of Medicine & Immunology, University of Washington, Seattle, WA, ³Division of Rheumatology, University of Washington, Seattle, WA, ⁴Rheumatology, University of Washington, Seattle, WA, ⁵Immunology, University of Washington, Seattle, WA
Background/Purpose: Effective clearance of apoptotic cells (AC) is necessary for the maintenance of tolerance to self. MFG-E8 is one of ~20 different opsonins reported to…
Abstract Number: 1145 • 2013 ACR/ARHP Annual Meeting
Regulation Of Plasmacytoid Dendritic Cells By Prostaglandin E2
Alice E. Wiedeman¹ and Keith B. Elkon², ¹Immunology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Plasmacytoid dendritic cells (pDCs) constitute a rare blood cell subset exquisitely attuned for production of large quantities of interferon-alpha (IFN-α), and these cells have…
Abstract Number: 1148 • 2013 ACR/ARHP Annual Meeting
Autologous Tolerogenic Dendritic Cells In Rheumatoid and Inflammatory Arthritis
Gillian Bell¹, Amy Anderson², Julie Diboll¹, Rachel Harry², Elaine McColl³, Anne Dickinson⁴, Catharien Hilkens¹ and John Isaacs⁵, ¹Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ²Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ³Clinical Trials Unit, Institute of Health and Society, NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ⁴Haematological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ⁵National Institute for Health Research, Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom
Background/Purpose: Rheumatoid arthritis is a chronic autoimmune disease which results from a breakdown of immune tolerance. Current therapies include traditional DMARDs, anti-TNF, B cell depleting…
Abstract Number: 573 • 2013 ACR/ARHP Annual Meeting
Absence Of Estrogen Receptor Alpha Reduces The Number and Function Of Bone Marrow Derived Plasmacytoid Dendritic Cells In Lupus Prone Mice
Jennifer Scott¹, Osama S. Naga², Melissa A. Cunningham³, Jena Wirth³, Jackie G. Eudaly² and Gary S. Gilkeson⁴, ¹Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, ²Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ³Med/Rheumatology, MUSC, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects women at a 9:1 ratio compared to men. Previous work in our laboratory…
Abstract Number: L2 • 2013 ACR/ARHP Annual Meeting
Proteome-Wide Analysis and CXCL4 As a Pathogenic Biomarker in Systemic Sclerosis
Timothy Radstake¹, Lenny van Bon², Alsya Affandi¹, Jasper Broen³, Romy Christmann⁴, Lukasz Stawski⁵, Giuseppina Farina⁶, Allison Mathes⁷, Marta Cossu⁸, MArk Wenink⁹, Roger Hesselstrand¹⁰, Tore Saxne¹¹, Dirk Wuttge¹⁰, John D. Reveille¹², Shervin Assassi¹², Maureen D. Mayes¹³, Wim B van den Berg¹⁴, Vanessa Smith¹⁵, Filip De Keyser¹⁵, Claudio Lunardi¹⁶, Piet L.C. Van Riel¹⁷, Madelon C. Vonk¹⁸, Lorenzo Beretta¹⁹, Maria Trojanowska²⁰ and Robert Lafyatis⁴, ¹Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht/Radboud University Nijmegen Medical Center, Utrecht/Nijmegen, Netherlands, ³Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Rheumatology, Boston Medical Center, Boston, MA, ⁶Arthritis center, Boston University, Boston, MA, ⁷rheumatology, Boston Medical Center, boston, MA, ⁸Rheumatology and Clinical Immunology, University Medical Center Utrecht, utrecht, Netherlands, ⁹rheumatology and Clinical Immunology, university Medical Center Utrecht, utrecht, Netherlands, ¹⁰Rheumatology, Lund University, Lund, Sweden, ¹¹Section of Rheumatology, Deparment of Clinical Sciences, Lund, Lund University, Lund, Sweden, ¹²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹³University of Texas Health Science Center at Houston, Houston, TX, ¹⁴Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ¹⁵Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ¹⁶Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹⁷Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁸Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁹Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²⁰Arthritis Center, Boston University, Boston, MA
Background/Purpose: We hypothesized that plasmacytoid dendritic cells are implicated in the pathogenesis of systemic sclerosis via mechanisms beyond previously suggested type I interferon production. Methods:…
Abstract Number: 2271 • 2012 ACR/ARHP Annual Meeting
Variation of Interferon-Alpha Production in Healthy Individuals and Association with Autoimmune Susceptibility Genes
Olof Berggren¹, Andrei Alexsson², Gunnar V. Alm³, Ann-Christine Syvänen⁴, Lars Rönnblom² and Maija-Leena Eloranta², ¹Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, ³Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden, ⁴Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala, Sweden
Background/Purpose: Many autoimmune diseases, e.g. systemic lupus erythematosus (SLE), have an activated type I interferon (IFN) system and about 40 SLE susceptibility loci, many within…
Abstract Number: 2273 • 2012 ACR/ARHP Annual Meeting
Functional Genetic Polymorphisms in Immunoglobulin-Like Transcript 3 Are Associated with Decreased Surface Expression On Dendritic Cells and Increased Serum Cytokines in Lupus Patients
Mark A. Jensen, Karen C. Patterson, Akaash A. Kumar, Marissa Kumabe, Beverly S. Franek and Timothy B. Niewold, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL
Background/Purpose: Hyperactivity of the type I interferon (IFN) pathway is involved in the pathogenesis of systemic lupus erythematosus (SLE). Immunoglobulin like transcript (ILT3) is an…
Abstract Number: 2073 • 2012 ACR/ARHP Annual Meeting
Green Tea Epigallocatechin-3-Gallate Ameliorates Murine Arthritis by Inducing IDO Producing Dendritic Cells Via Nrf2 Antioxidant Pathway
Soyoun Min¹, Mei Yan¹, Kamala Vanarsa², Anna Bashmakov¹ and Chandra Mohan¹, ¹Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, ²Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: To examine the immunomodulatory effects and mechanisms of Green Tea (−)-epigallocatechin-3-gallate (EGCG) on experimental arthritis in mice, we investigated whether EGCG can afford therapeutic…
Abstract Number: 1076 • 2012 ACR/ARHP Annual Meeting
FLIP in Dendritic Cells May Regulate Hematopoietic Homeostasis and Modulating Inflammation and Immunity
Qi Quan Huang¹, Robert Birkett², Harris R. Perlman³ and Richard M. Pope⁴, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: We previously demonstrated that FLIP in myeloid linage cells is necessary for neutrophil homeostasis and macrophage differentiation. Therefore studies were performed to determine the…
Abstract Number: 1079 • 2012 ACR/ARHP Annual Meeting
Polyclonal CD4⁺Foxp3⁺treg Cells Induce TGFb-Dependent Tolerogenic Dendritic Cells That Suppress Murine Lupus-Like Syndrome
Qin Lan¹ and Song G. Zheng², ¹Medicine, University of Southern California, Los Angeles, CA, ²Medicine, Keck School of Medicine of USC, Los Angeles, CA
Background/Purpose: Interplay between Foxp3+ regulatory T cells (Treg) and dendritic cells (DCs) maintains immunologic tolerance, but the effects of each cell on the other are…
Abstract Number: 1055 • 2012 ACR/ARHP Annual Meeting
Sec61 Is Indispensable for Antigen Cross-Presentation and the Development of Lupus Nephritis: A Novel ‘Self-Organized Criticality Theory’ Explaining the Cause of Systemic Lupus Erythematosus (SLE)
Ken Tsumiyama and Shunichi Shiozawa, Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
Abstract Number: 327 • 2012 ACR/ARHP Annual Meeting
Tolerogenic Dendritic Cells Ameliorates the Disease Severity of Murine Collagen-Induced Arthritis
Bin Ning¹, Shang-You Yang², Jianlu Wei¹, Weiming Gong¹ and Paul H. Wooley², ¹Orthopaedic Surgery, Shandong University Jinan Central Hospital, Jinan, China, ²Orthopaedic Research Institute, Via Christi Wichita Hospitals, Wichita, KS
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by synovial inflammation, cartilage breakdown and bone destruction with the involvement of various types of…

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