Abstracts tagged "dendritic cells and tofacitnib"

Abstract Number: 726 • 2013 ACR/ARHP Annual Meeting
Tofacitinib Does Not Inhibit Dendritic Cell Maturation and T Cell Proliferation In Vitro
Emmanuelle Le Bras^1,2, Dagmar Halbritter³ and Martin Fleck^2,4, ¹Internal Medicine I, University Medical Center of Regensburg, Regensburg 93053, Germany, ²Rheumatology & Clinical Immunology, Asklepios Clinic Bad Abbach, Bad Abbach, Germany, ³Internal Medicine I, University Medical Center of Regensburg, 93042 Regensburg, Germany, ⁴Internal Medicine I, University Medical Center of Regensburg, Regensburg, Germany
Background/Purpose: Tofacitinib is the first approved Janus Kinase (JAK) Inhibitor for the treatment of rheumatoid arthritis (RA). The JAK/STAT pathway-inhibition leads to dysfunction of several…