Abstracts tagged "dendritic cells and systemic lupus erythematosus (SLE)"

Abstract Number: 2978 • 2017 ACR/ARHP Annual Meeting
OX40/OX40L Axis Impairs Follicular and Natural Regulatory T Cell Function in Human Systemic Lupus
Christophe Richez¹, Jean-Francois Augusto², Clement Jacquemin³, Estibaliz Lazaro⁴, Marie-Elise Truchetet¹, Noémie Gensous⁵, Isabelle Douchet⁵, Thierry Schaeverbeke⁶, Cécile Contin-Bordes⁷ and Patrick Blanco⁷, ¹Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France, ²Department of Nephrology, Angers University Hospital, Angers, France, ³Université de Bordeaux, Bordeaux, France, ⁴Department of Internal Medecine and Clinical Immunology, Bordeaux University Hospital, Pessac, France, ⁵UMR CNRS 5164, Bordeaux, France, ⁶Department of Rheumatology, Bordeaux University Hospital, BORDEAUX, France, ⁷Immunology, Department of Immunology, Bordeaux University Hospital, Bordeaux, France
Background/Purpose: Regulatory T cells (Treg) are impaired in human Systemic Lupus Erythematosus (SLE) and contribute to T cell activation. However, the mechanisms responsible for the…
Abstract Number: 2323 • 2012 ACR/ARHP Annual Meeting
A Genetic Polymorphism on New Zealand Black Chromosome 1 Is Associated with Abnormal Dendritic Cell Function Leading to Expansion of T_H1, T_H17 and T Follicular Helper (T_FH) Cells
Nafiseh Talaei¹, Carolina Landolt-Marticorena², Babak Noamani¹, Evelyn Pau³, Nan-Hua Chang⁴ and Joan E. Wither⁵, ¹Genetics and developmental biology, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Rheumatology, University Health Network, Toronto, ON, Canada, ³Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ⁴Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁵1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: We have previously shown that B6 mice with an introgressed homozygous New Zealand Black chromosome (c) 1 interval (70 to 100 cM) develop high titres…
Abstract Number: 2679 • 2012 ACR/ARHP Annual Meeting
Loss of Caspase 8 in Dendritic Cells Induces a Systemic Lupus Erythematosus-Like Disease That Is Independent of the Necroptosome
Carla M. Cuda¹, Alexander V. Misharin², Rana Saber², G. Kenneth Haines III³, Jack Hutcheson⁴, Chandra Mohan⁵ and Harris R. Perlman⁶, ¹Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University, Chicago, IL, ³Department of Pathology, Yale University, New Haven, CT, ⁴Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, ⁵Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-organ, destructive autoimmune disease characterized by pathogenic autoantibodies. Though it is accepted that dendritic cells (DCs) play an…

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