Abstracts tagged "dendritic cells and skin"

Abstract Number: 2853 • 2018 ACR/ARHP Annual Meeting
A Protective Langerhans Cell-Keratinocyte Axis That Is Dysfunctional in Photosensitivity
William D. Shipman^1,2,3, Susan Chyou¹, Anusha Ramanathan¹, Peter M. Izmirly⁴, Sneh Sharma⁵, Tania Pannellini⁶, Dragos Dasoveanu¹, Xiaoping Qing⁷, Cynthia Magro⁸, Richard Granstein⁹, Michelle Lowes¹⁰, Eric Pamer¹¹, Daniel Kaplan¹², Jane E. Salmon^13,14, Babak Mehrara¹⁵, James Young^10,11,16,17, Robert M. Clancy¹⁸, Carl Blobel^14,19,20 and Theresa T. Lu^2,3,21, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, ³Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, ⁴Rheumatology, NYU School of Medicine, New York, NY, ⁵Laboratory of Cellular Immunobiology, Memorial Sloan Kettering Cancer Center, New York, NY, ⁶Hospital for Special Surgery, New York, NY, ⁷Program in Inflammation and Autoimmunity, Hospital for Special Surgery, New York, NY, ⁸Pathology, Weill Cornell Medicine, New York, NY, ⁹Dermatology, Weill Cornell Medicine, New York, NY, ¹⁰Rockefeller University, New York, NY, ¹¹Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, ¹²Immunology, University of Pittsburgh, New, NY, ¹³Medicine/Rheumatology, Hospital for Special Surgery, New York, NY, ¹⁴Weill Cornell Medicine, New York, NY, ¹⁵Plastic Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, ¹⁶Immunology, Memorial Sloan Kettering Cancer Center, New York, NY, ¹⁷Medicine, Weill Cornell Medicine, New York, NY, ¹⁸Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ¹⁹Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ²⁰Institute of Advanced Studies, Technical University of Munich, New York, NY, ²¹Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Photosensitivity, or skin sensitivity to ultraviolet radiation (UVR), is a feature of lupus erythematosus (LE) and other autoimmune conditions. Photosensitive lesions can be disfiguring…

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