Abstracts tagged "dendritic cells and rheumatoid arthritis (RA)"

Abstract Number: 3143 • 2016 ACR/ARHP Annual Meeting
The Caspase 8/RIPK3 Signaling Axis in Dendritic Cells Controls Joint Homeostasis Under Steady-State and Arthritic Conditions
Salina Dominguez¹, Harris R. Perlman² and Carla Cuda¹, ¹Northwestern University, Chicago, IL, ²Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Rheumatoid arthritis (RA) manifests in persistent synovial inflammation, cellular infiltration and pro-inflammatory cytokine production, and results in progressive joint destruction. Dendritic cells (DCs) have…
Abstract Number: 1939 • 2015 ACR/ARHP Annual Meeting
Anti-GM-CSF Treatment Promotes Synovial Monocyte-Derived Dendritic Cells and Increases Th17 Cells during Experimental Arthritis
Debbie M. Roeleveld¹, Peter M. van der Kraan¹, Wim B. van den Berg¹, Ian P. Wicks² and Marije I. Koenders¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Background/Purpose: Monocyte-derived dendritic cells (MoDCs) differentiate from monocytes under inflammatory conditions like RA, and are very potent in presenting antigen to T cells. GM-CSF-responsive MoDCs…
Abstract Number: 340 • 2014 ACR/ARHP Annual Meeting
Role of Beta-Catenin Signaling to Control Dendritic Cell Function in Collagen-Induced Arthritis
Celso Henrique Alves^1,2, Julia L. Ober-Blöbaum³, Inge Brouwers-Haspels^1,2, Patrick S. Asmawidjaja^1,2, Anne-Marie Mus^1,2, Björn E. Clausen³ and Erik Lubberts^2,4, ¹Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, ⁴Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and synovial infiltration of immune cells. T-cell priming by activated dendritic cells (DCs)…
Abstract Number: 949 • 2013 ACR/ARHP Annual Meeting
Targeting CD1c-Expressing Mdcs To Inhibit Tcell Activation and Thymus and Activation Regulated Chemokine (TARC)-Dependent Chemotaxis In RA
M.R. Hillen^1,2, F.M. Moret^1,3, F.P.J.G. Lafeber⁴, C.E. Hack⁴, T.R.D.J. Radstake^2,5 and J.A.G. van Roon^3,6, ¹Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, ⁵Laboratory for Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ⁶Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Recently, we demonstrated strong Th1 and Th17 cytokine induction by CD1c+ myeloid dendritic cells (mDCs) from synovial fluid and identified thymic stromal lympopoeitin (TSLP)…
Abstract Number: 929 • 2013 ACR/ARHP Annual Meeting
Blockade Of TNFα Produced By TSLP-Primed CD1c Myeloid Dendritic Cells Skews T Cell Response To Th2 Activity In Rheumatoid Arthritis Patients
F.M. Moret¹, T.R.D.J. Radstake², J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and J.A.G. van Roon³, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Additionally, TSLP and…
Abstract Number: 2335 • 2012 ACR/ARHP Annual Meeting
Increased TSLP Expression in Joints of Rheumatoid Arthritis Patients Causes Increased Activation of Intra-Articular Myeloid Dendritic Cells with Enhanced Th1 and Th17 Cell Activity
F.M. Moret¹, C.E. Hack², T.R.D.J. Radstake³, J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and J.A.G. van Roon⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Immunology, UMC Utrecht, Utrecht, Netherlands, ³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Administration of TSLP…
Abstract Number: 2150 • 2012 ACR/ARHP Annual Meeting
Action of Tofacitinib Via Human Dendritic Cells
Satoshi Kubo¹, Kunihiro Yamaoka², Shigeru Iwata¹ and Yoshiya Tanaka¹, ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Tofacitinib, an oral Janus Kinase (JAK) inhibitor, has gathered attention in treatment of Rheumatoid arthritis (RA). Although JAKs are well known for its importance…
Abstract Number: 1786 • 2012 ACR/ARHP Annual Meeting
Targeting CD1c-Expressing mDCs to Inhibit Increased Thymus and Activation Regulated Chemokine Levels in RA
M.R. Hillen¹, F.M. Moret¹, F.P.J.G. Lafeber², C.E. Hack³, T.R.D.J. Radstake⁴ and J.A.G. van Roon⁵, ¹Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymus and activation regulated chemokine (TARC) is a chemotactic factor that attracts cells expressing CCR4, including CD4 T cells with Th2, Th17 and Treg…
Abstract Number: 1788 • 2012 ACR/ARHP Annual Meeting
TSLP Induces TNFα Production by CD1c Myeloid Dendritic Cells and Myeloid DC-Activated T Cells From Rheumatoid Arthritis Patients
F.M. Moret¹, T.R.D.J. Radstake², J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and J.A.G. van Roon³, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Fibroblasts from rheumatoid arthritis…
Abstract Number: 1064 • 2012 ACR/ARHP Annual Meeting
CD1c-Expressing Myeloid Dendritic Cells From Joints of Rheumatoid Arthritis Patients Produce Increased Levels of T Cell-Attracting Chemokines and Strongly Activate Autologous T Cells
F.M. Moret¹, C.E. Hack², F.P.J.G. Lafeber¹, T.R.D.J. Radstake¹ and J.A.G. van Roon¹, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Immunology, UMC Utrecht, Utrecht, Netherlands
Background/Purpose: Myeloid dendritic cells (mDCs) are potent T cell-activating antigen-presenting cells that have been implicated to play a crucial role in the regulation of tolerance…
Abstract Number: 1070 • 2012 ACR/ARHP Annual Meeting
CD11c+ Dendritic Cells Play an Important Proinflammatory Role in Inflammatory Arthritis
Antonia Puchner¹, Stephan Blüml², Harald Leiss², Victoria Saferding³ and Kurt Redlich⁴, ¹Dpt of Rheumatology, Medical University Vienna, Vienna, Austria, ²Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Dendritic cells (DCs) play an important role in bridging innate and adaptive immune responses by serving as antigen presenting cells. Therefore DCs are implicated…

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