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Abstracts tagged "dendritic cells and hormones"

  • Abstract Number: 2790 • ACR/ARHP Annual Meeting 2016

    Selective Disruption of Estrogen Receptor Alpha Expression in Dendritic Cells of Lupus-Prone Mice Results in Increased Female-Specific Death

    Melissa A. Cunningham1, Jena R. Wirth2, Jackie G. Eudaly2 and Gary S. Gilkeson3, 1Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 2Med/Rheumatology, Medical University of South Carolina, Charleston, SC, 3Department of Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: SLE is a disease that disproportionately affects females. The etiology of the sex bias in this disease is unclear. We previously showed that a…
  • Abstract Number: 1213 • ACR/ARHP Annual Meeting 2014

    Absence of Hormone Responsive Estrogen Receptor Alpha Reduces the Activation of Plasmacytoid Dendritic Cells in Lupus Prone Mice

    Jennifer L. Scott1, Melissa A. Cunningham2, Osama S. Naga3, Jackie G. Eudaly3, Jena R. Wirth4 and Gary S. Gilkeson5, 1Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 2Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 3Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, 4Med/Rheumatology, MUSC, Charleston, SC, 5Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC

    Background/Purpose Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects women at a 9 to 1 ratio compared to men. To further understand…
  • Abstract Number: 637 • ACR/ARHP Annual Meeting 2014

    Decreased Inflammatory Dendritic Cells in Lupus-Prone Estrogen Receptor Alpha Knockout (ERαKO) Mice Correlate with Increased Survival

    Melissa A. Cunningham1, Jena R. Wirth2, Jackie G. Eudaly3, Jennifer L. Scott4, Osama S. Naga3 and Gary S. Gilkeson5, 1Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 2Med/Rheumatology, MUSC, Charleston, SC, 3Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, 4Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 5Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: SLE is a disease that disproportionately affects females. The etiology of the sex bias in this disease is unclear. We previously showed that a…

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