Abstracts tagged "demethylated FoxP3"

Abstract Number: 98 • 2019 ACR/ARP Annual Meeting
Selective Induction of Functional Regulatory T-Cells in Healthy Volunteers by NKTR-358, a Novel IL-2 Conjugate Treg Stimulator, in Development for the Treatment of Autoimmune Diseases
Christie Fanton¹, Neha Dixit ¹, Suresh Siddhanti ¹, Lin Lu ¹, Daniel Dickerson ², Brian Kotzin ¹ and Jonathan Zalevsky ¹, ¹Nektar Therapeutics, San Francisco, ²PRA Health Sciences, Lenexa
Background/Purpose: Regulatory T cell (Treg) dysfunction and impaired IL-2 production have been implicated as key immunological defects in multiple autoimmune diseases. Enhanced sensitivity of Tregs…

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Abstracts tagged "demethylated FoxP3"

Selective Induction of Functional Regulatory T-Cells in Healthy Volunteers by NKTR-358, a Novel IL-2 Conjugate Treg Stimulator, in Development for the Treatment of Autoimmune Diseases