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Abstracts tagged "demethylated FoxP3"

  • Abstract Number: 98 • ACR/ARP Annual Meeting 2019

    Selective Induction of Functional Regulatory T-Cells in Healthy Volunteers by NKTR-358, a Novel IL-2 Conjugate Treg Stimulator, in Development for the Treatment of Autoimmune Diseases

    Christie Fanton1, Neha Dixit 1, Suresh Siddhanti 1, Lin Lu 1, Daniel Dickerson 2, Brian Kotzin 1 and Jonathan Zalevsky 1, 1Nektar Therapeutics, San Francisco, 2PRA Health Sciences, Lenexa

    Background/Purpose: Regulatory T cell (Treg) dysfunction and impaired IL-2 production have been implicated as key immunological defects in multiple autoimmune diseases. Enhanced sensitivity of Tregs…
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