ACR Meeting Abstracts

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Abstracts tagged "Damage Index"

  • Abstract Number: L13 • ACR Convergence 2024

    Anifrolumab Long-Term Treatment Is More Effective Against Organ Damage Than Standard of Care Alone: Results from an External Control Arm Study on Organ Damage in Phase 3 Clinical Trials and the University of Toronto Lupus Clinic Cohort

    Zahi Touma1, Ian Bruce2, Richard A. Furie3, Eric Morand4, Raj Tummala5, Shelly Chandran6, Gabriel Abreu7, Jacob Knagenhjelm7, Kellyn Arnold8, Hopin Lee8, Eleanor Ralphs8, Danuta Kielar9, Aleksander Bedenkov9 and Miina Waratani9, 1Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, 2Queen's University Belfast, Belfast, United Kingdom, 3Northwell Health, Manhasset, NY, 4Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, 5BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 6Astrazeneca, Mississauga, ON, Canada, 7BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 8IQVIA, London, United Kingdom, 9Biopharmaceuticals Medicine, AstraZeneca, Cambridge, United Kingdom

    Background/Purpose: In SLE, persistent disease activity, disease flares and long-term glucocorticoid (GC) use all contribute to organ damage accrual. The effects of novel therapies on…
  • Abstract Number: 2328 • ACR Convergence 2024

    Do Patients That Develop PsA Before Psoriasis Have Different Disease Outcomes?

    Fadi Kharouf1, Virginia Carrizo Abarza2, Shangyi Gao3, Daniel Pereira4, Richard Cook5, Vinod Chandran6 and Dafna Gladman7, 1University Health Network and University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, 2Toronto Western Hospital - University of Toronto, Toronto, ON, Canada, 3Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 4University Health Network, Toronto, ON, Canada, 5University of Waterloo, Waterloo, Canada, 6University of Toronto, Toronto, ON, Canada, 7University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Most patients with Psoriatic Arthritis (PsA) experience psoriasis (Ps) before the onset of arthritis. However, in about 15% of the cases, the skin and…
  • Abstract Number: 2374 • ACR Convergence 2024

    Characteristics, Treatment Responses and Prognosis in a Single Center Cohort of SLE Patients with Thrombocytopenia

    Omer Uludag1, Sarvan Aghamuradov1, Cansu Erel Gezegen2, Marjan Jabbarli2, Ismat Habibov2, Ahmet Oguz Celik2, Yasemin Yalcinkaya1, Ahmet Gul1, Murat Inanc1 and Bahar Artim Esen1, 1Istanbul University, Istanbul Faculty of Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey

    Background/Purpose: Thrombocytopenia has been reported at frequencies ranging from 10 to 40 % in different cohorts. Treatment can be challenging and due to its considerable…
  • Abstract Number: 0118 • ACR Convergence 2024

    Performance of the 2023 ACR/EULAR Classification Criteria for Antiphospholipid Syndrome in a Mexican Cohort

    Erik Cimé-Aké1, Gabriela Hernández-Molina2, Amaya Llorente-Chávez3 and Eduardo Martin Nares2, 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Immunology and Rheumatology Department, Mexico City, Mexico, 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Hematology Department, Mexico City, Distrito Federal, Mexico

    Background/Purpose: The 2023 ACR/EULAR classification criteria (2023 AECC) for antiphospholipid syndrome (APS) were recently published. The new criteria require an entry criterion and employe a…
  • Abstract Number: 2375 • ACR Convergence 2024

    Can Damage Items Be Graded According to Severity in a Revised Organ Damage Index for Lupus?

    Burak Kundakci1, Megan Barber2, Ann E. Clarke2, Sindhu Johnson3, Ian Bruce1 and On behalf of the revised SLE organ damage index (SDI) collaborators4, 1Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, 2Division of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 3Division of Rheumatology, Department of Medicine, Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western and Mount Sinai Hospitals; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, 4University of Manchester, Manchester, United Kingdom

    Background/Purpose: The Systemic Lupus International Collaborating Clinics (SLICC), Lupus Foundation of America (LFA), and American College of Rheumatology (ACR) are leading a global initiative to…
  • Abstract Number: 0122 • ACR Convergence 2024

    Association of Cognitive Impairment Measured by Montreal Cognitive Assessment and Plasma Levels of Growth Differentiation Factor 15 in Patients with Antiphospholipid Antibody Syndrome

    Evelyn Aranda Cano1, Jessica Roldan Ortega2, Yaneli Juárez-Vicuña3, Fausto Sánchez Muñoz4, Itzel Palafox Sosa5, Luz Angelica Viruel-Mejia6, David Vera Bustamante7, Luis H. Silveira Torre8, Angélica Vargas Guerrero9, Mayra Nadia Quintanar-Cuevas10, Erick Giovanny Bautista Jímenez11 and Laura Aline Martinez-Martinez12, 1Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de Mexico, Mexico, 2Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, Mexico, 3Instituto Nacional del Cardiología Ignacio Chávez, México, Distrito Federal, Mexico, 4Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, 5Escuela Superior de Medicina-Instituto Politecnico Nacional, Ciudad de México, Mexico, 6Rheumatology Departement at National Institute of Cardiology Ignacio Chavez - Universidad Autonoma del Estado de Hidalgo, Tula de Allende, Hidalgo, Mexico, 7Benemerita Universidad Autonoma de Puebla, Heroica Puebla de Zaragoza, Puebla, Mexico, 8Department of Rheumatology , Instituto Nacional de Cardiología Ignacio Chávez., Mexico City, Mexico, 9Department of Rheumatology , Instituto Nacional de Cardiología Ignacio Chávez., México, Mexico, 10Mental health outpatient clinic of the National Institute of Cardiology Ignacio Chavez, México, Mexico, 11Hospital General de Zona No. 27 del Instituto Mexicano del Seguro Social, Mexico, Distrito Federal, Mexico, 12Rheumatology Department - National Institute of Cardiology Ignacio Chavez, Mexico City, Distrito Federal, Mexico

    Background/Purpose: Growth differentiation factor 15 (GDF-15), is a stress induced inflammatory cytokine, member of the transforming growth factor-β superfamily, tissue injury. It is predominantly expressed…
  • Abstract Number: 2403 • ACR Convergence 2024

    Health-related Quality of Life in Women with Systemic Lupus Erythematosus with Permanent Skin Damage and Its Association with Self-esteem and Symptoms of Depression and Anxiety – a Cross-sectional Study

    Fernando A Oliveira1, Fabiana Moura2, Ana Flávia Dias3, Claudia Santoro3, Fernando Pereira2, Rosa Telles2 and Cristina Lanna2, 1Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, 2Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, 3Grupo Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil

    Background/Purpose: Body image of systemic lupus erythematosus (SLE) patients is affected by the mucocutaneous manifestations and its scars, in particular related to discoid lupus. The…
  • Abstract Number: 0123 • ACR Convergence 2024

    The Impact of Sedentary Behavior and Physical Activity Level on Clinical Parameters and Quality of Life in Patients with Primary Antiphospholipid Syndrome (PAPS)

    Carla Silva1 and Danieli Andrade2, 1University of Sao Paulo, Salvador, Bahia, Brazil, 2University of São Paulo, São Paulo, SP, Brazil

    Background/Purpose: PAPS is an autoimmune disease marked by thrombosis, obstetric poor outcomes and antiphospholipid antibodies. Despite treatment, APS is associated with high morbidity and mortality,…
  • Abstract Number: 2443 • ACR Convergence 2024

    The Clinical Phenotype of Anti-Th/To+ Patients in Systemic Sclerosis: A Case-control Study Within the European Scleroderma Trials and Research (EUSTAR) Cohort

    Liala Moschetti1, Eleonora Pedretti2, Francesco Bonomi3, María Martín López4, Fabio Cacciapaglia5, cristiana sieiro santos6, Gianluca Moroncini7, Yannick Allanore8, Joana Caetano9, Brigitte Granel10, Laura Groseanu11, Maria De Santis12, Masataka Kuwana13, Veronica Codullo14, Mariana Pereira Silva15, Pietro Bearzi16, Laura Belloli17, Alida Taberner-Cortés18, Cristina Maglio19, Francesco Del Galdo20, Corrado Campochiaro21, Marie-Elise Truchetet22, Giovanna Cuomo23, Magda Parvu24, Florenzo Iannone25, Patricia Carreira26, Serena Guiducci27, Franco Franceschini1, Paolo Airò1 and Maria-Grazia Lazzaroni1, 1Scleroderma Unit, Rheumatology and Clinical Immunology Unit, ERN ReCONNET, ASST Spedali Civili, Brescia, Italy, Brescia, Italy, 2Scleroderma Unit, Rheumatology Unit, ERN ReCONNET, ASST Spedali Civili and University of Brescia; Italy, Brescia, Italy, 3Division of Rheumatology, Scleroderma Unit, University of Florence, AOU Careggi Firenze; Italy, Firenze, Italy, 4General University Hospital of Ciudad Real, Ciudad de México, Spain, 5Rheumatology Unit � DiMePRe-J, University and AOU Policlinico of Bari, Italy, Bari, Italy, 6Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, 7Marche Polytechnic University, Ancona, Italy, 8Rheumatology department, Université Paris Cité, Cochin Hospital of Paris; France, Paris, France, 9Systemic Autoimmune Diseases Unit, Fernando Fonseca Hospital, Amadora; Portugal, Amadora, Portugal, 10Service de Médecine Interne Hôpital Nord de Marseille; France, Marseille, France, 11Spitalul Sfanta Maria, Bucharest, Romania, 12Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital and Biomedical Sciences, Hu-manitas University, Milan; Italy, Milan, Italy, 13Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, 14Unit of Rheumatology, San Matteo Hospital, Pavia, Italy, 15Rheumatology Department, Unidade Local de Saúde Santa Maria, Centro Académico de Medicina de Lisboa; Portugal, Lisboa, Portugal, 16Immunorheumatology Unit, Università Campus Bio-Medico University of Roma; Italy, Roma, Italy, 17Niguarda Hospital, Milan, Milan, Italy, 18Hospital Universitario Doctor Peset, Valencia, Spain, 19University of Gothenburg, Gothenburg, Sweden, 20University of Leeds, Leeds, United Kingdom, 21IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milan, Milan, Italy, 22Bordeaux University Hospital, Bordeaux, France, 23Università degli studi della Campania Luigi Vanvitelli, Napoli, Italy, 24Colentina Clinical Hospital, Rheumatology Department, Bucharest; Romania, Bucharest, Romania, 25Rheumatology Unit- University of Bari "Aldo Moro", IT, Bari, Italy, 26Hospital Universitario 12 de Octubre, Madrid, Madrid, Spain, 27Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Background/Purpose: To evaluate clinical associations of anti-Th/To antibodies in SSc patients in a multicentre international cohort, focusing on interstitial lung disease (ILD), pulmonary arterial hypertension…
  • Abstract Number: 0128 • ACR Convergence 2024

    Damage Index in Patients with Thrombotic Antiphospholipid Syndrome (DIAPS) Version 2.0: One Single Center Pilot Study

    Laura Aline Martinez-Martinez1, Mary-Carmen Amigo2 and María Victoria Goycochea Robles3, 1Rheumatology Department - National Institute of Cardiology Ignacio Chavez, Mexico City, Distrito Federal, Mexico, 2ABC Medical Center, Mexico City, Estado de México, Mexico, 3Universidad Nacional Autonoma de Mexico, Mexico city, Distrito Federal, Mexico

    Background/Purpose: Antiphospholipid antibody syndrome is the main acquired thrombophilia in the rheumatological area. It is characterized by thrombotic events and obstetric morbidity associated with the…
  • Abstract Number: 0185 • ACR Convergence 2024

    New and Severe Damage in a Prevalent Lupus Cohort Through the Lens of Demographic and Neighborhood Disparities

    Jonathan Katz1, Ang Yu2, Felix Elwert2, Robert Greenlee3, David Gazeley4, Ann Rosenthal5, Jenna Cormier5, Bryn Sutherland5, Shalvi Parikh6, Yiran Jiang7 and Christie Bartels8, 1University of Wisconsin Hospitals and Clinics, Madison, WI, 2University of Wisconsin-Madison, Madison, WI, 3Marshfield Clinical Research Institute, Marshfield, WI, 4Medical College of Wisconsin, Wauwatosa, WI, 5Medical College of Wisconsin, Milwaukee, WI, 6Mississippi Delta Family Medicine Residency, Greenville, MS, 7Annapolis Rheumatology, Washington, DC, 8University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: Systemic Lupus Erythematosus (SLE) disproportionally affects minoritized populations.  SLE damage, assessed by SLICC/ACR Damage Index (SDI), is higher in Black than in White US…
  • Abstract Number: 0286 • ACR Convergence 2024

    Damage Associated with Disease-Specific Effects and Diagnostic or Therapeutic Procedures Is Highly Prevalent in IgG4-Related Disease

    Guy Katz1, Zachary Wallace2, Cory Perugino1, Grace McMahon1, Isha Jha1, Ana Fernandes1 and John Stone3, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Newton, MA, 3Massachusetts General Hospital , Harvard Medical School, Concord, MA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease that can affect nearly any organ or anatomic site. Although the disease responds well to glucocorticoids…
  • Abstract Number: 0555 • ACR Convergence 2024

    The Effect of Alcohol Consumption on Clinical Outcomes and Structural Damage in Patients with Axial Spondyloarthritis: A Systematic Literature Review and Meta-Analysis

    Sinead Maguire1, Nigil Haroon2, Robert Inman3, Melanie Anderson4, Evelyne Gendron5 and Sindhu R. Johnson6, 1University of Toronto, University Health Network, Schroeder Arthritis Institute, Department of Rheumatology, Toronto, Canada, 2Department of Medicine/Rheumatology, University Health Network, Schroeder Arthritis Institute, University of Toronto, Toronto, ON, Canada, 3University Health Network, Toronto, ON, Canada, 4The Institute for Education Research, Library and Information Services, University Health Network, Toronto, ON, Canada, 5University of Toronto, University Health Network, Schroeder Arthritis Institute, Department of Rheumatology, Quebec City, QC, Canada, 6University of Toronto, Toronto, Canada

    Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic progressive inflammatory disease characterized by the involvement of the axial skeleton. Alcohol consumption (AC) is a modifiable lifestyle…
  • Abstract Number: 0621 • ACR Convergence 2024

    Predictive Parameters of Disease-related Damage Accrual in Patients with Systemic Lupus Erythematosus: A Machine Learning Analysis

    Omer Pamuk1 and Hasan Cetin2, 1University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH, 2Cleveland Clinic Cole Eye Institute, Cleveland, OH

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory disease that can affect multiple organs and systems. While there has been an improvement in…
  • Abstract Number: 0624 • ACR Convergence 2024

    Coexisting Tubulointerstitial Inflammation and Damage Is a Risk Factor for Chronic Kidney Disease in Patients with Lupus Nephritis

    Dong-Jin Park1, Hyemin Jeong2, Sung-Eun Choi3, Ji-Hyoun Kang2 and Shin-Seok Lee4, 1Chonnam National University Medical School and Hospital, Gwangju, South Korea, 2Chonnam National University Hospital, Gwangju, South Korea, 3Chonnam National University Medical School & Hospital, Gwangju, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, KR, Gwangju, Republic of Korea

    Background/Purpose: Conflicting studies have reported varying associations between tubulointerstitial inflammation (TII), tubulointerstitial damage (TID), and the long-term outcomes of lupus nephritis (LN), due to analyzing…
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